Septiembre 2016InvestigaciónBoletín de N°41

Unidad de Investigación Grupo Investigación en Cáncer IDC Correo: epidemiologia@idclasamericas.co Tel: 340 93 93 ext. 5426 - 5461

Authors: D Gómez-Almaguer, A Vázquez-Mellado, J R Navarro-Cabrera, V Abello-Polo, V Milovic, J García, A L Basquiera, S Saba, G Balladares, J Vela-Ojeda, S Gómez, A Karduss-Aurueta, A Bustinza-Álvarez, A Requejo, L Feldman, J C Jaime-Pérez, S Yantorno, G Kusminsky, C H Gutiérrez-Aguirre, J Arbelbide, J Martinez-Rolon, G Jarchum, G Jaimovich, L Riera, E Pedraza-Mesa, L Villamizar-Gómez, M Á Herrera-Rojas, M M Gamboa-Alonso, C Foncuberta, G Rodríguez-González, M A García Ruiz-Esparza, E Hernández-Maldonado, M Paz-Infanzón, E González-López and G J Ruiz-Argüelles.

We studied 298 patients with severe aplastic anaemia (SAA) allografted in four Latin American countries. The source of cells was bone marrow (BM) in 94 patients and PBSCs in 204 patients. Engraftment failed in 8.1% of recipients with no difference between BM and PBSCs (P=0.08). Incidence of acute GvHD (aGvHD) for BM and PBSCs was 30% vs 32% (P=0.18), and for grades III–IV was 2.6% vs 11.6% (P=0.01). Chronic GvHD (cGvHD) between BM and PBSCs was 37% vs 59% (P=0.002) and extensive 5% vs 23.6% (P=0.01). OS was 74% vs 76% for BM vs PBSCs (P=0.95). Event-free survival was superior in patients conditioned with anti-thymocyte globulin (ATG)-based regimens compared with other regimens (79% vs 61%, P=0.001) as excessive secondary graft failure was seen with other regimens (10% vs 26%, P=0.005) respectively. In multivariate analysis, aGvHD II–IV (hazard ratio (HR) 2.50, confidence interval (CI) 1.1–5.6, P=0.02) and aGvHD III–IV (HR 8.3 CI 3.4–20.2, P<0.001) proved to be independent negative predictors of survival. In conclusion, BM as a source of cells and ATG-based regimens should be standard because of higher GvHD incidence with PBSCs, although the latter combining with ATG in the conditioning regimen could be an option in selected high-risk patients.

The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants.

ARTÍCULO PUBLICADO EN LA REVISTA BONE MARROW TRANSPLANTATIONImpact Factor 3.636

Authors: Luis V. Syro, Fabio Rotondo, Carlos A. Serna, León D. Ortiz, Kalman Kovacs.

Introduction: Histologic, immunohistochemical and electron microscopic studies have provided conclusive evidence that a marked diversity exists between tumors which secrete growth hormone (GH) in excess. GH cell hyperplasia can also be associated with acromegaly in patients with extrapituitary GH—releasing hormone secreting tumors or in familial pituitary tumor syndromes.Materials and methods: A literature search was performed for information regarding pathology, GH-producing tumors and acromegaly. Results: This review summarizes the current knowledge on the morphology of GH-producing and silent GH adenomas, as well as GH hyperplasia of the pituitary.Conclusion: The importance of morphologic classification and identification of different subgroups of patients with GH-producing adenomas and their impact on clinical management is discussed.

Pathology of GH-producing pituitary adenomas and GH cell hyperplasia of the pituitary

ARTÍCULO PUBLICADO EN LA REVISTA PITUITARY Impact Factor: 3.407

El pasado 15 y 16 de Septiembre de 2016 la Universidad de Antioquia-Facultad de Enfermería realizó el V CONGRESO NACIONAL Y IV INTERNACIONAL DE ATENCIÓN AL PACIENTE CON HERIDAS; en el cual se presentó la ponencia “Cambio del paradigma: Los cambios son efectivos si provienen del que usa el registro, asociado a que el registro de enfermería es parte del cuidado. Investigadora: Bertha Cecilia Téllez Murcia.

PRESENTACIÓN TRABAJO DE ENFERMERIA