I had a long post about why upregulate autophagy while doing senolytics was a good idea, but its gone now.Probably about 6 hours worth of research, links, and typing; just gone...Isn't it amazing how Google Docs and Gmail are able to save every keystroke..?IP.Board, this forum software, does have an autosave feature:http://community.inv...auto-save-post/But until its enabled my reply has to be:Yes they are related and it does seem to be a good idea to upregulate autophagy while doing Senolytics.It seems to be tying into the NAD+ World too:"...quercetin increases gene expression of the NQO1 gene via an Nrf2 transcription factor mediated pathway(ref)(ref)(ref). Specfically, quercetin enhances the binding of Nrf2 to the NRF-ARE binding site on the NQO1 gene promoter. Quercetin also increases Nrf2-mediated transcriptional activity by up regulation gut e expression of Nrf2 mRNA and Nrf2 protein. Quercetin also reduces the level of Keap1 protein, the binding partner of Nrf2, which prevents Nrf2 nuclear translocation. Quercetin reduces Keap-1in a post-translational mechanism, thereby reducing Nrf2 ubiquitination and proteasomal degradation..."