mc: trastorno de la marcha eaneurologiauruguay.org/home/images//deficitb12.pdf · s. cordonal...
TRANSCRIPT
Ma A B ANo Reg 770085
56 antildeosSexo femenino
Raza NegraDiestra
Primaria incompleta (3ordm)Ama de Casa
Cno Maldonado Km 16FC 141105
MC Trastorno de la marchaEA Comienza hace 3 meses con dificultad en la marcha
que refiere como disminucioacuten de fuerzas en MMII global de instalacioacuten insidiosa lentamente progresiva que la lleva
a deambular con apoyo unilateral Agrega concomitantemente deacuteficit sensitivo en MMII que refiere
como ldquocaminar en el airerdquo y que empeora claramente en la oscuridad Refiere ademaacutes edema MII hasta raiacutez de muslo Niega alteraciones esfinterianas No refiere nivel sensitivo en tronco No dolor raquiacutedeo ni radicular No alteraciones
en MMSS ni a nivel craneal No siacutentomas respiratorios
AEA En mayo 2005 fue internada por cuadro de repercusioacuten general y siacutendrome funcional aneacutemico de varios meses de evolucioacuten A destacar de la paraclinica Hb 7 VCM 93 GB 1200 Nt 280 PLT 35000 Metabolismo Fe N Vit B12 169 Ac Foacutelico N Interpretaacutendose el cuadro hematoloacutegico como pancitopenia de causa multicarencial se realiza Tto con Complejo B Ac Foacutelico Sulfato Ferroso y Calcio (todo por VO) llegando a nuevo Hemograma Hb 97 GB 2800 PLT 262000 por lo que se otorga alta hospitalaria quedando pendiente Mielograma que mostroacute finalmente meacutedula oacutesea rica con reactividad eritroide y megaloblastos marcados polilobocitos alteraciones morfoloacutegicas de la serie eritroide y granular Anisopoiquilocitosis cuerpos de Howell anillos de Cabot La paciente continuoacute hasta la consulta con el mismo Tto indicado al alta
AP Dislipemia en Tto c Atorvastatina No HTA No DM No ETS No Tab ni OH No exp Toacutexicos
AF Nada a destacar MSEC Deficitario
EFN Bradipsiquica apaacutetica FAI sp PC sp Maseterino normal SM sp SE MM SS TONO discreta espasticidad de pronadores
bilateral y simeacutetrica FUERZAS conservadas ROT aumentados con aumento del area y difusioacuten Hoffman y Troumlemers (+) COORDINACIOacuteN normal SENSIBILIDAD Normal
TRONCO sp No nivel sensitivo MM II TONO espasticidad (Ash 1) ext y add
FUERZAS paresia global moderada vence gravedad opone resistencia REFLEJOS rotuliano vivo con aumento del area y difusioacuten aquiliano algo disminuido bilateral y simeacutetrico Babinski bilateral Rossolimo y Mendel - Bechterew en flexioacuten SENSIBILIDAD hipopalestesia global 4 seg eias apalestesia distal Sensibilidad termoalgesica conservada
ESTATICA Signo de Romberg sin latencia MARCHA Ataacutexica Pareto-espaacutesticaEFEN Edema MII hasta raiacutez de muslo
1) iquestCuaacutel es el diagnoacutestico sindromaacutetico y topograacutefico
2) iquestCuaacutel es la causa de esta complicacioacuten neuroloacutegica
3) iquestPlanteariacutea diagnoacutesticos diferenciales en lo etioloacutegico
4) iquestQueacute estudios se deben solicitar5) iquestCuaacutel es el tratamiento correcto de esta
entidad6) iquestQueacute hecho puede plantearse como
desencadenante de la complicacioacuten neuroloacutegica referida
1) iquestCuaacutel es el diagnoacutestico sindromaacutetico y topograacutefico
S CORDONAL POSTERIOR S PIRAMIDAL
S NEUROANEacuteMICO
DCSM
DESMIELINIZACION DEFICIT DE VITAMINA B 12 TRASTORNO DE LA ABSORCIOacuteN GASTRITIS ATROFICA AUTOINMUNE ANTICUERPOS ANTIFACTOR INTRINSECO
DCSA + ANEMIA MEGALOBLASTICA
+ HIPOVITAMINOSIS B12
RESECCIOacuteN GASTRICA O ILEAL SIacuteNDROME DEL ASA CIEGA POR ESTANCAMIENTO DEL CONTENIDO INTESTINAL Y SOBRECRECIMIENTO BACTERIANO QUE
COMPITE CON LA CBL DE LA INGESTA Y PUEDE OCURRIR POR DIVERTICULOSIS YEYUNAL ENTEROANASTOMOSIS TUBERCULOSIS CIRUGIacuteAS PREVIAS ENFERMEDAD DE CROHN FIacuteSTULAS INFILTRACIOacuteN LINFOMATOSA TAMBIEacuteN PUEDE EXISTIR SOBRECRECIMIENTO BACTERIANO SI ESTAacute ALTERADA LA MOTILIDAD INTESTINAL COMO EN LA ESCLERODERMIA O AMILOIDOSIS O EN LA HIPOGAMMAGLOBULINEMIA
S NO DISOCIACIOacuteN B12 OMEPRAZOL COLCHICINA NEOMICINA FENITOINA BIGUANIDAS ETANOL ENFERMEDAD CELIACA
DIPHYLLOBOTRIUM LATUM (CESTODO)
LACTOVEGETARIANOS ESTRICTOS
LACTANTES DE MADRES CON DEF VIT B12 INTOXICACIOacuteN POR OacuteXIDO NITROSO DEFECTO GENEacuteTICO EN LA METILMALONIL COENZIMA A (COA) MUTASA SIacuteNDROME DE ZOLLINGER-ELLISON POR INACTIVACIOacuteN DE LAS ENZIMAS PANCREAacuteTICAS RADIOTERAPIA LOCAL QUE AFECTE AL IacuteLEON O IRRADIACIOacuteN CORPORAL TOTAL INFECCIOacuteN POR VIH SE HAN DETECTADO NIVELES BAJOS DE CBL EN UN 10-35 POR CIENTO Y SE HA DEMOSTRADO
MALABSORCIOacuteN NO CORRE FI ENFERMEDAD INJERTO CONTRA HUEacuteSPED QUE AFECTE AL INTESTINO DELGADO SIacuteNDROME DE IMERSLUND DEFECTO CONGEacuteNITO DE LOS RECEPTORES INTESTINALES DE FI ANOMALIacuteAS EN EL METABOLISMO DE LA VIT B12 DEacuteFICIT CONGEacuteNITO DE TRANSCOBALAMINA II ACIDURIA
CONGEacuteNITA METILMALOacuteNICA Y HOMOCISTINURIA
HEMOGRAMA DOS B12 FGC - BIOPSIAAC ANTIFACTOR INTRINSECO AC ANTICELULAS PARIETALES
NEOPOLIGLANDULAR
COBALAMINA 1000 gammas im diacutea x 1 SEMANA
1 SEMANA X 1 MES 1 MES de por VIDA
LA ldquoTRAMPArdquo DEL ACIDO FOLICO
Copyright copy 2007 by the American Roentgen Ray Society
Ravina B et al Am J Roentgenol 2000174863-865
52-year-old man with
Subacute combined
degeneration of
spinal cord
Rev Meacuted Chile 2004 132 1377-1382Mielopatiacutea por deacuteficit de vitamina B12 caracterizacioacuten cliacutenica de 11 casosJorge Nogales-Gaete
Reversible Myelopathy in a 34-Year-Old Man With Vitamin B12 DeficiencySEAN J PITTOCK MD TROY A PAYNE MD AND C MICHEL HARPER MD
Mayo Clin Proc 200277291-294
Copyright copy2008 Canadian Medical Association or its licensors
Wong C L et al CMAJ 2008178279-281
Magnetic resonance imaging scans of the brain showing changes consistent with cobalamin deficiency
N Engl J Med 1952 Jul 3247(1)15-7 Links
Studies on the mutual effect of suboptimal oral doses of vitamin B12 and folic acid in pernicious anemia
REISNER EH WEINER L
PMID 14941273 [PubMed - indexed for MEDLINE]
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
AEA En mayo 2005 fue internada por cuadro de repercusioacuten general y siacutendrome funcional aneacutemico de varios meses de evolucioacuten A destacar de la paraclinica Hb 7 VCM 93 GB 1200 Nt 280 PLT 35000 Metabolismo Fe N Vit B12 169 Ac Foacutelico N Interpretaacutendose el cuadro hematoloacutegico como pancitopenia de causa multicarencial se realiza Tto con Complejo B Ac Foacutelico Sulfato Ferroso y Calcio (todo por VO) llegando a nuevo Hemograma Hb 97 GB 2800 PLT 262000 por lo que se otorga alta hospitalaria quedando pendiente Mielograma que mostroacute finalmente meacutedula oacutesea rica con reactividad eritroide y megaloblastos marcados polilobocitos alteraciones morfoloacutegicas de la serie eritroide y granular Anisopoiquilocitosis cuerpos de Howell anillos de Cabot La paciente continuoacute hasta la consulta con el mismo Tto indicado al alta
AP Dislipemia en Tto c Atorvastatina No HTA No DM No ETS No Tab ni OH No exp Toacutexicos
AF Nada a destacar MSEC Deficitario
EFN Bradipsiquica apaacutetica FAI sp PC sp Maseterino normal SM sp SE MM SS TONO discreta espasticidad de pronadores
bilateral y simeacutetrica FUERZAS conservadas ROT aumentados con aumento del area y difusioacuten Hoffman y Troumlemers (+) COORDINACIOacuteN normal SENSIBILIDAD Normal
TRONCO sp No nivel sensitivo MM II TONO espasticidad (Ash 1) ext y add
FUERZAS paresia global moderada vence gravedad opone resistencia REFLEJOS rotuliano vivo con aumento del area y difusioacuten aquiliano algo disminuido bilateral y simeacutetrico Babinski bilateral Rossolimo y Mendel - Bechterew en flexioacuten SENSIBILIDAD hipopalestesia global 4 seg eias apalestesia distal Sensibilidad termoalgesica conservada
ESTATICA Signo de Romberg sin latencia MARCHA Ataacutexica Pareto-espaacutesticaEFEN Edema MII hasta raiacutez de muslo
1) iquestCuaacutel es el diagnoacutestico sindromaacutetico y topograacutefico
2) iquestCuaacutel es la causa de esta complicacioacuten neuroloacutegica
3) iquestPlanteariacutea diagnoacutesticos diferenciales en lo etioloacutegico
4) iquestQueacute estudios se deben solicitar5) iquestCuaacutel es el tratamiento correcto de esta
entidad6) iquestQueacute hecho puede plantearse como
desencadenante de la complicacioacuten neuroloacutegica referida
1) iquestCuaacutel es el diagnoacutestico sindromaacutetico y topograacutefico
S CORDONAL POSTERIOR S PIRAMIDAL
S NEUROANEacuteMICO
DCSM
DESMIELINIZACION DEFICIT DE VITAMINA B 12 TRASTORNO DE LA ABSORCIOacuteN GASTRITIS ATROFICA AUTOINMUNE ANTICUERPOS ANTIFACTOR INTRINSECO
DCSA + ANEMIA MEGALOBLASTICA
+ HIPOVITAMINOSIS B12
RESECCIOacuteN GASTRICA O ILEAL SIacuteNDROME DEL ASA CIEGA POR ESTANCAMIENTO DEL CONTENIDO INTESTINAL Y SOBRECRECIMIENTO BACTERIANO QUE
COMPITE CON LA CBL DE LA INGESTA Y PUEDE OCURRIR POR DIVERTICULOSIS YEYUNAL ENTEROANASTOMOSIS TUBERCULOSIS CIRUGIacuteAS PREVIAS ENFERMEDAD DE CROHN FIacuteSTULAS INFILTRACIOacuteN LINFOMATOSA TAMBIEacuteN PUEDE EXISTIR SOBRECRECIMIENTO BACTERIANO SI ESTAacute ALTERADA LA MOTILIDAD INTESTINAL COMO EN LA ESCLERODERMIA O AMILOIDOSIS O EN LA HIPOGAMMAGLOBULINEMIA
S NO DISOCIACIOacuteN B12 OMEPRAZOL COLCHICINA NEOMICINA FENITOINA BIGUANIDAS ETANOL ENFERMEDAD CELIACA
DIPHYLLOBOTRIUM LATUM (CESTODO)
LACTOVEGETARIANOS ESTRICTOS
LACTANTES DE MADRES CON DEF VIT B12 INTOXICACIOacuteN POR OacuteXIDO NITROSO DEFECTO GENEacuteTICO EN LA METILMALONIL COENZIMA A (COA) MUTASA SIacuteNDROME DE ZOLLINGER-ELLISON POR INACTIVACIOacuteN DE LAS ENZIMAS PANCREAacuteTICAS RADIOTERAPIA LOCAL QUE AFECTE AL IacuteLEON O IRRADIACIOacuteN CORPORAL TOTAL INFECCIOacuteN POR VIH SE HAN DETECTADO NIVELES BAJOS DE CBL EN UN 10-35 POR CIENTO Y SE HA DEMOSTRADO
MALABSORCIOacuteN NO CORRE FI ENFERMEDAD INJERTO CONTRA HUEacuteSPED QUE AFECTE AL INTESTINO DELGADO SIacuteNDROME DE IMERSLUND DEFECTO CONGEacuteNITO DE LOS RECEPTORES INTESTINALES DE FI ANOMALIacuteAS EN EL METABOLISMO DE LA VIT B12 DEacuteFICIT CONGEacuteNITO DE TRANSCOBALAMINA II ACIDURIA
CONGEacuteNITA METILMALOacuteNICA Y HOMOCISTINURIA
HEMOGRAMA DOS B12 FGC - BIOPSIAAC ANTIFACTOR INTRINSECO AC ANTICELULAS PARIETALES
NEOPOLIGLANDULAR
COBALAMINA 1000 gammas im diacutea x 1 SEMANA
1 SEMANA X 1 MES 1 MES de por VIDA
LA ldquoTRAMPArdquo DEL ACIDO FOLICO
Copyright copy 2007 by the American Roentgen Ray Society
Ravina B et al Am J Roentgenol 2000174863-865
52-year-old man with
Subacute combined
degeneration of
spinal cord
Rev Meacuted Chile 2004 132 1377-1382Mielopatiacutea por deacuteficit de vitamina B12 caracterizacioacuten cliacutenica de 11 casosJorge Nogales-Gaete
Reversible Myelopathy in a 34-Year-Old Man With Vitamin B12 DeficiencySEAN J PITTOCK MD TROY A PAYNE MD AND C MICHEL HARPER MD
Mayo Clin Proc 200277291-294
Copyright copy2008 Canadian Medical Association or its licensors
Wong C L et al CMAJ 2008178279-281
Magnetic resonance imaging scans of the brain showing changes consistent with cobalamin deficiency
N Engl J Med 1952 Jul 3247(1)15-7 Links
Studies on the mutual effect of suboptimal oral doses of vitamin B12 and folic acid in pernicious anemia
REISNER EH WEINER L
PMID 14941273 [PubMed - indexed for MEDLINE]
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
EFN Bradipsiquica apaacutetica FAI sp PC sp Maseterino normal SM sp SE MM SS TONO discreta espasticidad de pronadores
bilateral y simeacutetrica FUERZAS conservadas ROT aumentados con aumento del area y difusioacuten Hoffman y Troumlemers (+) COORDINACIOacuteN normal SENSIBILIDAD Normal
TRONCO sp No nivel sensitivo MM II TONO espasticidad (Ash 1) ext y add
FUERZAS paresia global moderada vence gravedad opone resistencia REFLEJOS rotuliano vivo con aumento del area y difusioacuten aquiliano algo disminuido bilateral y simeacutetrico Babinski bilateral Rossolimo y Mendel - Bechterew en flexioacuten SENSIBILIDAD hipopalestesia global 4 seg eias apalestesia distal Sensibilidad termoalgesica conservada
ESTATICA Signo de Romberg sin latencia MARCHA Ataacutexica Pareto-espaacutesticaEFEN Edema MII hasta raiacutez de muslo
1) iquestCuaacutel es el diagnoacutestico sindromaacutetico y topograacutefico
2) iquestCuaacutel es la causa de esta complicacioacuten neuroloacutegica
3) iquestPlanteariacutea diagnoacutesticos diferenciales en lo etioloacutegico
4) iquestQueacute estudios se deben solicitar5) iquestCuaacutel es el tratamiento correcto de esta
entidad6) iquestQueacute hecho puede plantearse como
desencadenante de la complicacioacuten neuroloacutegica referida
1) iquestCuaacutel es el diagnoacutestico sindromaacutetico y topograacutefico
S CORDONAL POSTERIOR S PIRAMIDAL
S NEUROANEacuteMICO
DCSM
DESMIELINIZACION DEFICIT DE VITAMINA B 12 TRASTORNO DE LA ABSORCIOacuteN GASTRITIS ATROFICA AUTOINMUNE ANTICUERPOS ANTIFACTOR INTRINSECO
DCSA + ANEMIA MEGALOBLASTICA
+ HIPOVITAMINOSIS B12
RESECCIOacuteN GASTRICA O ILEAL SIacuteNDROME DEL ASA CIEGA POR ESTANCAMIENTO DEL CONTENIDO INTESTINAL Y SOBRECRECIMIENTO BACTERIANO QUE
COMPITE CON LA CBL DE LA INGESTA Y PUEDE OCURRIR POR DIVERTICULOSIS YEYUNAL ENTEROANASTOMOSIS TUBERCULOSIS CIRUGIacuteAS PREVIAS ENFERMEDAD DE CROHN FIacuteSTULAS INFILTRACIOacuteN LINFOMATOSA TAMBIEacuteN PUEDE EXISTIR SOBRECRECIMIENTO BACTERIANO SI ESTAacute ALTERADA LA MOTILIDAD INTESTINAL COMO EN LA ESCLERODERMIA O AMILOIDOSIS O EN LA HIPOGAMMAGLOBULINEMIA
S NO DISOCIACIOacuteN B12 OMEPRAZOL COLCHICINA NEOMICINA FENITOINA BIGUANIDAS ETANOL ENFERMEDAD CELIACA
DIPHYLLOBOTRIUM LATUM (CESTODO)
LACTOVEGETARIANOS ESTRICTOS
LACTANTES DE MADRES CON DEF VIT B12 INTOXICACIOacuteN POR OacuteXIDO NITROSO DEFECTO GENEacuteTICO EN LA METILMALONIL COENZIMA A (COA) MUTASA SIacuteNDROME DE ZOLLINGER-ELLISON POR INACTIVACIOacuteN DE LAS ENZIMAS PANCREAacuteTICAS RADIOTERAPIA LOCAL QUE AFECTE AL IacuteLEON O IRRADIACIOacuteN CORPORAL TOTAL INFECCIOacuteN POR VIH SE HAN DETECTADO NIVELES BAJOS DE CBL EN UN 10-35 POR CIENTO Y SE HA DEMOSTRADO
MALABSORCIOacuteN NO CORRE FI ENFERMEDAD INJERTO CONTRA HUEacuteSPED QUE AFECTE AL INTESTINO DELGADO SIacuteNDROME DE IMERSLUND DEFECTO CONGEacuteNITO DE LOS RECEPTORES INTESTINALES DE FI ANOMALIacuteAS EN EL METABOLISMO DE LA VIT B12 DEacuteFICIT CONGEacuteNITO DE TRANSCOBALAMINA II ACIDURIA
CONGEacuteNITA METILMALOacuteNICA Y HOMOCISTINURIA
HEMOGRAMA DOS B12 FGC - BIOPSIAAC ANTIFACTOR INTRINSECO AC ANTICELULAS PARIETALES
NEOPOLIGLANDULAR
COBALAMINA 1000 gammas im diacutea x 1 SEMANA
1 SEMANA X 1 MES 1 MES de por VIDA
LA ldquoTRAMPArdquo DEL ACIDO FOLICO
Copyright copy 2007 by the American Roentgen Ray Society
Ravina B et al Am J Roentgenol 2000174863-865
52-year-old man with
Subacute combined
degeneration of
spinal cord
Rev Meacuted Chile 2004 132 1377-1382Mielopatiacutea por deacuteficit de vitamina B12 caracterizacioacuten cliacutenica de 11 casosJorge Nogales-Gaete
Reversible Myelopathy in a 34-Year-Old Man With Vitamin B12 DeficiencySEAN J PITTOCK MD TROY A PAYNE MD AND C MICHEL HARPER MD
Mayo Clin Proc 200277291-294
Copyright copy2008 Canadian Medical Association or its licensors
Wong C L et al CMAJ 2008178279-281
Magnetic resonance imaging scans of the brain showing changes consistent with cobalamin deficiency
N Engl J Med 1952 Jul 3247(1)15-7 Links
Studies on the mutual effect of suboptimal oral doses of vitamin B12 and folic acid in pernicious anemia
REISNER EH WEINER L
PMID 14941273 [PubMed - indexed for MEDLINE]
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
1) iquestCuaacutel es el diagnoacutestico sindromaacutetico y topograacutefico
2) iquestCuaacutel es la causa de esta complicacioacuten neuroloacutegica
3) iquestPlanteariacutea diagnoacutesticos diferenciales en lo etioloacutegico
4) iquestQueacute estudios se deben solicitar5) iquestCuaacutel es el tratamiento correcto de esta
entidad6) iquestQueacute hecho puede plantearse como
desencadenante de la complicacioacuten neuroloacutegica referida
1) iquestCuaacutel es el diagnoacutestico sindromaacutetico y topograacutefico
S CORDONAL POSTERIOR S PIRAMIDAL
S NEUROANEacuteMICO
DCSM
DESMIELINIZACION DEFICIT DE VITAMINA B 12 TRASTORNO DE LA ABSORCIOacuteN GASTRITIS ATROFICA AUTOINMUNE ANTICUERPOS ANTIFACTOR INTRINSECO
DCSA + ANEMIA MEGALOBLASTICA
+ HIPOVITAMINOSIS B12
RESECCIOacuteN GASTRICA O ILEAL SIacuteNDROME DEL ASA CIEGA POR ESTANCAMIENTO DEL CONTENIDO INTESTINAL Y SOBRECRECIMIENTO BACTERIANO QUE
COMPITE CON LA CBL DE LA INGESTA Y PUEDE OCURRIR POR DIVERTICULOSIS YEYUNAL ENTEROANASTOMOSIS TUBERCULOSIS CIRUGIacuteAS PREVIAS ENFERMEDAD DE CROHN FIacuteSTULAS INFILTRACIOacuteN LINFOMATOSA TAMBIEacuteN PUEDE EXISTIR SOBRECRECIMIENTO BACTERIANO SI ESTAacute ALTERADA LA MOTILIDAD INTESTINAL COMO EN LA ESCLERODERMIA O AMILOIDOSIS O EN LA HIPOGAMMAGLOBULINEMIA
S NO DISOCIACIOacuteN B12 OMEPRAZOL COLCHICINA NEOMICINA FENITOINA BIGUANIDAS ETANOL ENFERMEDAD CELIACA
DIPHYLLOBOTRIUM LATUM (CESTODO)
LACTOVEGETARIANOS ESTRICTOS
LACTANTES DE MADRES CON DEF VIT B12 INTOXICACIOacuteN POR OacuteXIDO NITROSO DEFECTO GENEacuteTICO EN LA METILMALONIL COENZIMA A (COA) MUTASA SIacuteNDROME DE ZOLLINGER-ELLISON POR INACTIVACIOacuteN DE LAS ENZIMAS PANCREAacuteTICAS RADIOTERAPIA LOCAL QUE AFECTE AL IacuteLEON O IRRADIACIOacuteN CORPORAL TOTAL INFECCIOacuteN POR VIH SE HAN DETECTADO NIVELES BAJOS DE CBL EN UN 10-35 POR CIENTO Y SE HA DEMOSTRADO
MALABSORCIOacuteN NO CORRE FI ENFERMEDAD INJERTO CONTRA HUEacuteSPED QUE AFECTE AL INTESTINO DELGADO SIacuteNDROME DE IMERSLUND DEFECTO CONGEacuteNITO DE LOS RECEPTORES INTESTINALES DE FI ANOMALIacuteAS EN EL METABOLISMO DE LA VIT B12 DEacuteFICIT CONGEacuteNITO DE TRANSCOBALAMINA II ACIDURIA
CONGEacuteNITA METILMALOacuteNICA Y HOMOCISTINURIA
HEMOGRAMA DOS B12 FGC - BIOPSIAAC ANTIFACTOR INTRINSECO AC ANTICELULAS PARIETALES
NEOPOLIGLANDULAR
COBALAMINA 1000 gammas im diacutea x 1 SEMANA
1 SEMANA X 1 MES 1 MES de por VIDA
LA ldquoTRAMPArdquo DEL ACIDO FOLICO
Copyright copy 2007 by the American Roentgen Ray Society
Ravina B et al Am J Roentgenol 2000174863-865
52-year-old man with
Subacute combined
degeneration of
spinal cord
Rev Meacuted Chile 2004 132 1377-1382Mielopatiacutea por deacuteficit de vitamina B12 caracterizacioacuten cliacutenica de 11 casosJorge Nogales-Gaete
Reversible Myelopathy in a 34-Year-Old Man With Vitamin B12 DeficiencySEAN J PITTOCK MD TROY A PAYNE MD AND C MICHEL HARPER MD
Mayo Clin Proc 200277291-294
Copyright copy2008 Canadian Medical Association or its licensors
Wong C L et al CMAJ 2008178279-281
Magnetic resonance imaging scans of the brain showing changes consistent with cobalamin deficiency
N Engl J Med 1952 Jul 3247(1)15-7 Links
Studies on the mutual effect of suboptimal oral doses of vitamin B12 and folic acid in pernicious anemia
REISNER EH WEINER L
PMID 14941273 [PubMed - indexed for MEDLINE]
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
1) iquestCuaacutel es el diagnoacutestico sindromaacutetico y topograacutefico
S CORDONAL POSTERIOR S PIRAMIDAL
S NEUROANEacuteMICO
DCSM
DESMIELINIZACION DEFICIT DE VITAMINA B 12 TRASTORNO DE LA ABSORCIOacuteN GASTRITIS ATROFICA AUTOINMUNE ANTICUERPOS ANTIFACTOR INTRINSECO
DCSA + ANEMIA MEGALOBLASTICA
+ HIPOVITAMINOSIS B12
RESECCIOacuteN GASTRICA O ILEAL SIacuteNDROME DEL ASA CIEGA POR ESTANCAMIENTO DEL CONTENIDO INTESTINAL Y SOBRECRECIMIENTO BACTERIANO QUE
COMPITE CON LA CBL DE LA INGESTA Y PUEDE OCURRIR POR DIVERTICULOSIS YEYUNAL ENTEROANASTOMOSIS TUBERCULOSIS CIRUGIacuteAS PREVIAS ENFERMEDAD DE CROHN FIacuteSTULAS INFILTRACIOacuteN LINFOMATOSA TAMBIEacuteN PUEDE EXISTIR SOBRECRECIMIENTO BACTERIANO SI ESTAacute ALTERADA LA MOTILIDAD INTESTINAL COMO EN LA ESCLERODERMIA O AMILOIDOSIS O EN LA HIPOGAMMAGLOBULINEMIA
S NO DISOCIACIOacuteN B12 OMEPRAZOL COLCHICINA NEOMICINA FENITOINA BIGUANIDAS ETANOL ENFERMEDAD CELIACA
DIPHYLLOBOTRIUM LATUM (CESTODO)
LACTOVEGETARIANOS ESTRICTOS
LACTANTES DE MADRES CON DEF VIT B12 INTOXICACIOacuteN POR OacuteXIDO NITROSO DEFECTO GENEacuteTICO EN LA METILMALONIL COENZIMA A (COA) MUTASA SIacuteNDROME DE ZOLLINGER-ELLISON POR INACTIVACIOacuteN DE LAS ENZIMAS PANCREAacuteTICAS RADIOTERAPIA LOCAL QUE AFECTE AL IacuteLEON O IRRADIACIOacuteN CORPORAL TOTAL INFECCIOacuteN POR VIH SE HAN DETECTADO NIVELES BAJOS DE CBL EN UN 10-35 POR CIENTO Y SE HA DEMOSTRADO
MALABSORCIOacuteN NO CORRE FI ENFERMEDAD INJERTO CONTRA HUEacuteSPED QUE AFECTE AL INTESTINO DELGADO SIacuteNDROME DE IMERSLUND DEFECTO CONGEacuteNITO DE LOS RECEPTORES INTESTINALES DE FI ANOMALIacuteAS EN EL METABOLISMO DE LA VIT B12 DEacuteFICIT CONGEacuteNITO DE TRANSCOBALAMINA II ACIDURIA
CONGEacuteNITA METILMALOacuteNICA Y HOMOCISTINURIA
HEMOGRAMA DOS B12 FGC - BIOPSIAAC ANTIFACTOR INTRINSECO AC ANTICELULAS PARIETALES
NEOPOLIGLANDULAR
COBALAMINA 1000 gammas im diacutea x 1 SEMANA
1 SEMANA X 1 MES 1 MES de por VIDA
LA ldquoTRAMPArdquo DEL ACIDO FOLICO
Copyright copy 2007 by the American Roentgen Ray Society
Ravina B et al Am J Roentgenol 2000174863-865
52-year-old man with
Subacute combined
degeneration of
spinal cord
Rev Meacuted Chile 2004 132 1377-1382Mielopatiacutea por deacuteficit de vitamina B12 caracterizacioacuten cliacutenica de 11 casosJorge Nogales-Gaete
Reversible Myelopathy in a 34-Year-Old Man With Vitamin B12 DeficiencySEAN J PITTOCK MD TROY A PAYNE MD AND C MICHEL HARPER MD
Mayo Clin Proc 200277291-294
Copyright copy2008 Canadian Medical Association or its licensors
Wong C L et al CMAJ 2008178279-281
Magnetic resonance imaging scans of the brain showing changes consistent with cobalamin deficiency
N Engl J Med 1952 Jul 3247(1)15-7 Links
Studies on the mutual effect of suboptimal oral doses of vitamin B12 and folic acid in pernicious anemia
REISNER EH WEINER L
PMID 14941273 [PubMed - indexed for MEDLINE]
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
DESMIELINIZACION DEFICIT DE VITAMINA B 12 TRASTORNO DE LA ABSORCIOacuteN GASTRITIS ATROFICA AUTOINMUNE ANTICUERPOS ANTIFACTOR INTRINSECO
DCSA + ANEMIA MEGALOBLASTICA
+ HIPOVITAMINOSIS B12
RESECCIOacuteN GASTRICA O ILEAL SIacuteNDROME DEL ASA CIEGA POR ESTANCAMIENTO DEL CONTENIDO INTESTINAL Y SOBRECRECIMIENTO BACTERIANO QUE
COMPITE CON LA CBL DE LA INGESTA Y PUEDE OCURRIR POR DIVERTICULOSIS YEYUNAL ENTEROANASTOMOSIS TUBERCULOSIS CIRUGIacuteAS PREVIAS ENFERMEDAD DE CROHN FIacuteSTULAS INFILTRACIOacuteN LINFOMATOSA TAMBIEacuteN PUEDE EXISTIR SOBRECRECIMIENTO BACTERIANO SI ESTAacute ALTERADA LA MOTILIDAD INTESTINAL COMO EN LA ESCLERODERMIA O AMILOIDOSIS O EN LA HIPOGAMMAGLOBULINEMIA
S NO DISOCIACIOacuteN B12 OMEPRAZOL COLCHICINA NEOMICINA FENITOINA BIGUANIDAS ETANOL ENFERMEDAD CELIACA
DIPHYLLOBOTRIUM LATUM (CESTODO)
LACTOVEGETARIANOS ESTRICTOS
LACTANTES DE MADRES CON DEF VIT B12 INTOXICACIOacuteN POR OacuteXIDO NITROSO DEFECTO GENEacuteTICO EN LA METILMALONIL COENZIMA A (COA) MUTASA SIacuteNDROME DE ZOLLINGER-ELLISON POR INACTIVACIOacuteN DE LAS ENZIMAS PANCREAacuteTICAS RADIOTERAPIA LOCAL QUE AFECTE AL IacuteLEON O IRRADIACIOacuteN CORPORAL TOTAL INFECCIOacuteN POR VIH SE HAN DETECTADO NIVELES BAJOS DE CBL EN UN 10-35 POR CIENTO Y SE HA DEMOSTRADO
MALABSORCIOacuteN NO CORRE FI ENFERMEDAD INJERTO CONTRA HUEacuteSPED QUE AFECTE AL INTESTINO DELGADO SIacuteNDROME DE IMERSLUND DEFECTO CONGEacuteNITO DE LOS RECEPTORES INTESTINALES DE FI ANOMALIacuteAS EN EL METABOLISMO DE LA VIT B12 DEacuteFICIT CONGEacuteNITO DE TRANSCOBALAMINA II ACIDURIA
CONGEacuteNITA METILMALOacuteNICA Y HOMOCISTINURIA
HEMOGRAMA DOS B12 FGC - BIOPSIAAC ANTIFACTOR INTRINSECO AC ANTICELULAS PARIETALES
NEOPOLIGLANDULAR
COBALAMINA 1000 gammas im diacutea x 1 SEMANA
1 SEMANA X 1 MES 1 MES de por VIDA
LA ldquoTRAMPArdquo DEL ACIDO FOLICO
Copyright copy 2007 by the American Roentgen Ray Society
Ravina B et al Am J Roentgenol 2000174863-865
52-year-old man with
Subacute combined
degeneration of
spinal cord
Rev Meacuted Chile 2004 132 1377-1382Mielopatiacutea por deacuteficit de vitamina B12 caracterizacioacuten cliacutenica de 11 casosJorge Nogales-Gaete
Reversible Myelopathy in a 34-Year-Old Man With Vitamin B12 DeficiencySEAN J PITTOCK MD TROY A PAYNE MD AND C MICHEL HARPER MD
Mayo Clin Proc 200277291-294
Copyright copy2008 Canadian Medical Association or its licensors
Wong C L et al CMAJ 2008178279-281
Magnetic resonance imaging scans of the brain showing changes consistent with cobalamin deficiency
N Engl J Med 1952 Jul 3247(1)15-7 Links
Studies on the mutual effect of suboptimal oral doses of vitamin B12 and folic acid in pernicious anemia
REISNER EH WEINER L
PMID 14941273 [PubMed - indexed for MEDLINE]
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
DCSA + ANEMIA MEGALOBLASTICA
+ HIPOVITAMINOSIS B12
RESECCIOacuteN GASTRICA O ILEAL SIacuteNDROME DEL ASA CIEGA POR ESTANCAMIENTO DEL CONTENIDO INTESTINAL Y SOBRECRECIMIENTO BACTERIANO QUE
COMPITE CON LA CBL DE LA INGESTA Y PUEDE OCURRIR POR DIVERTICULOSIS YEYUNAL ENTEROANASTOMOSIS TUBERCULOSIS CIRUGIacuteAS PREVIAS ENFERMEDAD DE CROHN FIacuteSTULAS INFILTRACIOacuteN LINFOMATOSA TAMBIEacuteN PUEDE EXISTIR SOBRECRECIMIENTO BACTERIANO SI ESTAacute ALTERADA LA MOTILIDAD INTESTINAL COMO EN LA ESCLERODERMIA O AMILOIDOSIS O EN LA HIPOGAMMAGLOBULINEMIA
S NO DISOCIACIOacuteN B12 OMEPRAZOL COLCHICINA NEOMICINA FENITOINA BIGUANIDAS ETANOL ENFERMEDAD CELIACA
DIPHYLLOBOTRIUM LATUM (CESTODO)
LACTOVEGETARIANOS ESTRICTOS
LACTANTES DE MADRES CON DEF VIT B12 INTOXICACIOacuteN POR OacuteXIDO NITROSO DEFECTO GENEacuteTICO EN LA METILMALONIL COENZIMA A (COA) MUTASA SIacuteNDROME DE ZOLLINGER-ELLISON POR INACTIVACIOacuteN DE LAS ENZIMAS PANCREAacuteTICAS RADIOTERAPIA LOCAL QUE AFECTE AL IacuteLEON O IRRADIACIOacuteN CORPORAL TOTAL INFECCIOacuteN POR VIH SE HAN DETECTADO NIVELES BAJOS DE CBL EN UN 10-35 POR CIENTO Y SE HA DEMOSTRADO
MALABSORCIOacuteN NO CORRE FI ENFERMEDAD INJERTO CONTRA HUEacuteSPED QUE AFECTE AL INTESTINO DELGADO SIacuteNDROME DE IMERSLUND DEFECTO CONGEacuteNITO DE LOS RECEPTORES INTESTINALES DE FI ANOMALIacuteAS EN EL METABOLISMO DE LA VIT B12 DEacuteFICIT CONGEacuteNITO DE TRANSCOBALAMINA II ACIDURIA
CONGEacuteNITA METILMALOacuteNICA Y HOMOCISTINURIA
HEMOGRAMA DOS B12 FGC - BIOPSIAAC ANTIFACTOR INTRINSECO AC ANTICELULAS PARIETALES
NEOPOLIGLANDULAR
COBALAMINA 1000 gammas im diacutea x 1 SEMANA
1 SEMANA X 1 MES 1 MES de por VIDA
LA ldquoTRAMPArdquo DEL ACIDO FOLICO
Copyright copy 2007 by the American Roentgen Ray Society
Ravina B et al Am J Roentgenol 2000174863-865
52-year-old man with
Subacute combined
degeneration of
spinal cord
Rev Meacuted Chile 2004 132 1377-1382Mielopatiacutea por deacuteficit de vitamina B12 caracterizacioacuten cliacutenica de 11 casosJorge Nogales-Gaete
Reversible Myelopathy in a 34-Year-Old Man With Vitamin B12 DeficiencySEAN J PITTOCK MD TROY A PAYNE MD AND C MICHEL HARPER MD
Mayo Clin Proc 200277291-294
Copyright copy2008 Canadian Medical Association or its licensors
Wong C L et al CMAJ 2008178279-281
Magnetic resonance imaging scans of the brain showing changes consistent with cobalamin deficiency
N Engl J Med 1952 Jul 3247(1)15-7 Links
Studies on the mutual effect of suboptimal oral doses of vitamin B12 and folic acid in pernicious anemia
REISNER EH WEINER L
PMID 14941273 [PubMed - indexed for MEDLINE]
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
RESECCIOacuteN GASTRICA O ILEAL SIacuteNDROME DEL ASA CIEGA POR ESTANCAMIENTO DEL CONTENIDO INTESTINAL Y SOBRECRECIMIENTO BACTERIANO QUE
COMPITE CON LA CBL DE LA INGESTA Y PUEDE OCURRIR POR DIVERTICULOSIS YEYUNAL ENTEROANASTOMOSIS TUBERCULOSIS CIRUGIacuteAS PREVIAS ENFERMEDAD DE CROHN FIacuteSTULAS INFILTRACIOacuteN LINFOMATOSA TAMBIEacuteN PUEDE EXISTIR SOBRECRECIMIENTO BACTERIANO SI ESTAacute ALTERADA LA MOTILIDAD INTESTINAL COMO EN LA ESCLERODERMIA O AMILOIDOSIS O EN LA HIPOGAMMAGLOBULINEMIA
S NO DISOCIACIOacuteN B12 OMEPRAZOL COLCHICINA NEOMICINA FENITOINA BIGUANIDAS ETANOL ENFERMEDAD CELIACA
DIPHYLLOBOTRIUM LATUM (CESTODO)
LACTOVEGETARIANOS ESTRICTOS
LACTANTES DE MADRES CON DEF VIT B12 INTOXICACIOacuteN POR OacuteXIDO NITROSO DEFECTO GENEacuteTICO EN LA METILMALONIL COENZIMA A (COA) MUTASA SIacuteNDROME DE ZOLLINGER-ELLISON POR INACTIVACIOacuteN DE LAS ENZIMAS PANCREAacuteTICAS RADIOTERAPIA LOCAL QUE AFECTE AL IacuteLEON O IRRADIACIOacuteN CORPORAL TOTAL INFECCIOacuteN POR VIH SE HAN DETECTADO NIVELES BAJOS DE CBL EN UN 10-35 POR CIENTO Y SE HA DEMOSTRADO
MALABSORCIOacuteN NO CORRE FI ENFERMEDAD INJERTO CONTRA HUEacuteSPED QUE AFECTE AL INTESTINO DELGADO SIacuteNDROME DE IMERSLUND DEFECTO CONGEacuteNITO DE LOS RECEPTORES INTESTINALES DE FI ANOMALIacuteAS EN EL METABOLISMO DE LA VIT B12 DEacuteFICIT CONGEacuteNITO DE TRANSCOBALAMINA II ACIDURIA
CONGEacuteNITA METILMALOacuteNICA Y HOMOCISTINURIA
HEMOGRAMA DOS B12 FGC - BIOPSIAAC ANTIFACTOR INTRINSECO AC ANTICELULAS PARIETALES
NEOPOLIGLANDULAR
COBALAMINA 1000 gammas im diacutea x 1 SEMANA
1 SEMANA X 1 MES 1 MES de por VIDA
LA ldquoTRAMPArdquo DEL ACIDO FOLICO
Copyright copy 2007 by the American Roentgen Ray Society
Ravina B et al Am J Roentgenol 2000174863-865
52-year-old man with
Subacute combined
degeneration of
spinal cord
Rev Meacuted Chile 2004 132 1377-1382Mielopatiacutea por deacuteficit de vitamina B12 caracterizacioacuten cliacutenica de 11 casosJorge Nogales-Gaete
Reversible Myelopathy in a 34-Year-Old Man With Vitamin B12 DeficiencySEAN J PITTOCK MD TROY A PAYNE MD AND C MICHEL HARPER MD
Mayo Clin Proc 200277291-294
Copyright copy2008 Canadian Medical Association or its licensors
Wong C L et al CMAJ 2008178279-281
Magnetic resonance imaging scans of the brain showing changes consistent with cobalamin deficiency
N Engl J Med 1952 Jul 3247(1)15-7 Links
Studies on the mutual effect of suboptimal oral doses of vitamin B12 and folic acid in pernicious anemia
REISNER EH WEINER L
PMID 14941273 [PubMed - indexed for MEDLINE]
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
HEMOGRAMA DOS B12 FGC - BIOPSIAAC ANTIFACTOR INTRINSECO AC ANTICELULAS PARIETALES
NEOPOLIGLANDULAR
COBALAMINA 1000 gammas im diacutea x 1 SEMANA
1 SEMANA X 1 MES 1 MES de por VIDA
LA ldquoTRAMPArdquo DEL ACIDO FOLICO
Copyright copy 2007 by the American Roentgen Ray Society
Ravina B et al Am J Roentgenol 2000174863-865
52-year-old man with
Subacute combined
degeneration of
spinal cord
Rev Meacuted Chile 2004 132 1377-1382Mielopatiacutea por deacuteficit de vitamina B12 caracterizacioacuten cliacutenica de 11 casosJorge Nogales-Gaete
Reversible Myelopathy in a 34-Year-Old Man With Vitamin B12 DeficiencySEAN J PITTOCK MD TROY A PAYNE MD AND C MICHEL HARPER MD
Mayo Clin Proc 200277291-294
Copyright copy2008 Canadian Medical Association or its licensors
Wong C L et al CMAJ 2008178279-281
Magnetic resonance imaging scans of the brain showing changes consistent with cobalamin deficiency
N Engl J Med 1952 Jul 3247(1)15-7 Links
Studies on the mutual effect of suboptimal oral doses of vitamin B12 and folic acid in pernicious anemia
REISNER EH WEINER L
PMID 14941273 [PubMed - indexed for MEDLINE]
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
COBALAMINA 1000 gammas im diacutea x 1 SEMANA
1 SEMANA X 1 MES 1 MES de por VIDA
LA ldquoTRAMPArdquo DEL ACIDO FOLICO
Copyright copy 2007 by the American Roentgen Ray Society
Ravina B et al Am J Roentgenol 2000174863-865
52-year-old man with
Subacute combined
degeneration of
spinal cord
Rev Meacuted Chile 2004 132 1377-1382Mielopatiacutea por deacuteficit de vitamina B12 caracterizacioacuten cliacutenica de 11 casosJorge Nogales-Gaete
Reversible Myelopathy in a 34-Year-Old Man With Vitamin B12 DeficiencySEAN J PITTOCK MD TROY A PAYNE MD AND C MICHEL HARPER MD
Mayo Clin Proc 200277291-294
Copyright copy2008 Canadian Medical Association or its licensors
Wong C L et al CMAJ 2008178279-281
Magnetic resonance imaging scans of the brain showing changes consistent with cobalamin deficiency
N Engl J Med 1952 Jul 3247(1)15-7 Links
Studies on the mutual effect of suboptimal oral doses of vitamin B12 and folic acid in pernicious anemia
REISNER EH WEINER L
PMID 14941273 [PubMed - indexed for MEDLINE]
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
LA ldquoTRAMPArdquo DEL ACIDO FOLICO
Copyright copy 2007 by the American Roentgen Ray Society
Ravina B et al Am J Roentgenol 2000174863-865
52-year-old man with
Subacute combined
degeneration of
spinal cord
Rev Meacuted Chile 2004 132 1377-1382Mielopatiacutea por deacuteficit de vitamina B12 caracterizacioacuten cliacutenica de 11 casosJorge Nogales-Gaete
Reversible Myelopathy in a 34-Year-Old Man With Vitamin B12 DeficiencySEAN J PITTOCK MD TROY A PAYNE MD AND C MICHEL HARPER MD
Mayo Clin Proc 200277291-294
Copyright copy2008 Canadian Medical Association or its licensors
Wong C L et al CMAJ 2008178279-281
Magnetic resonance imaging scans of the brain showing changes consistent with cobalamin deficiency
N Engl J Med 1952 Jul 3247(1)15-7 Links
Studies on the mutual effect of suboptimal oral doses of vitamin B12 and folic acid in pernicious anemia
REISNER EH WEINER L
PMID 14941273 [PubMed - indexed for MEDLINE]
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
Copyright copy 2007 by the American Roentgen Ray Society
Ravina B et al Am J Roentgenol 2000174863-865
52-year-old man with
Subacute combined
degeneration of
spinal cord
Rev Meacuted Chile 2004 132 1377-1382Mielopatiacutea por deacuteficit de vitamina B12 caracterizacioacuten cliacutenica de 11 casosJorge Nogales-Gaete
Reversible Myelopathy in a 34-Year-Old Man With Vitamin B12 DeficiencySEAN J PITTOCK MD TROY A PAYNE MD AND C MICHEL HARPER MD
Mayo Clin Proc 200277291-294
Copyright copy2008 Canadian Medical Association or its licensors
Wong C L et al CMAJ 2008178279-281
Magnetic resonance imaging scans of the brain showing changes consistent with cobalamin deficiency
N Engl J Med 1952 Jul 3247(1)15-7 Links
Studies on the mutual effect of suboptimal oral doses of vitamin B12 and folic acid in pernicious anemia
REISNER EH WEINER L
PMID 14941273 [PubMed - indexed for MEDLINE]
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
Rev Meacuted Chile 2004 132 1377-1382Mielopatiacutea por deacuteficit de vitamina B12 caracterizacioacuten cliacutenica de 11 casosJorge Nogales-Gaete
Reversible Myelopathy in a 34-Year-Old Man With Vitamin B12 DeficiencySEAN J PITTOCK MD TROY A PAYNE MD AND C MICHEL HARPER MD
Mayo Clin Proc 200277291-294
Copyright copy2008 Canadian Medical Association or its licensors
Wong C L et al CMAJ 2008178279-281
Magnetic resonance imaging scans of the brain showing changes consistent with cobalamin deficiency
N Engl J Med 1952 Jul 3247(1)15-7 Links
Studies on the mutual effect of suboptimal oral doses of vitamin B12 and folic acid in pernicious anemia
REISNER EH WEINER L
PMID 14941273 [PubMed - indexed for MEDLINE]
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
Reversible Myelopathy in a 34-Year-Old Man With Vitamin B12 DeficiencySEAN J PITTOCK MD TROY A PAYNE MD AND C MICHEL HARPER MD
Mayo Clin Proc 200277291-294
Copyright copy2008 Canadian Medical Association or its licensors
Wong C L et al CMAJ 2008178279-281
Magnetic resonance imaging scans of the brain showing changes consistent with cobalamin deficiency
N Engl J Med 1952 Jul 3247(1)15-7 Links
Studies on the mutual effect of suboptimal oral doses of vitamin B12 and folic acid in pernicious anemia
REISNER EH WEINER L
PMID 14941273 [PubMed - indexed for MEDLINE]
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
Copyright copy2008 Canadian Medical Association or its licensors
Wong C L et al CMAJ 2008178279-281
Magnetic resonance imaging scans of the brain showing changes consistent with cobalamin deficiency
N Engl J Med 1952 Jul 3247(1)15-7 Links
Studies on the mutual effect of suboptimal oral doses of vitamin B12 and folic acid in pernicious anemia
REISNER EH WEINER L
PMID 14941273 [PubMed - indexed for MEDLINE]
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
N Engl J Med 1952 Jul 3247(1)15-7 Links
Studies on the mutual effect of suboptimal oral doses of vitamin B12 and folic acid in pernicious anemia
REISNER EH WEINER L
PMID 14941273 [PubMed - indexed for MEDLINE]
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
J Lab Clin Med 1959 Jan53(1)22-38 Links
Folic acid and vitamin B12 in pernicious anemia studies on patients treated with these substances over a ten year period
WILL JJ MUELLER JF BRODINE C KIELY CE FRIEDMAN B HAWKINS VR DUTRA J VILTER RW
PMID 13621020 [PubMed - indexed for MEDLINE]
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
Rev Meacuted Chile 2004 132 1377-1382
ldquoNos llama la atencioacuten la asociacioacuten al menos temporal entre el aumento de casos observados y el inicio del programa de suplementacioacuten de la harina con aacutecido foacutelico (22 mgkilo) iniciada en enero de 2000 en Chilerdquohellip ldquoAtendiendo a esta potencial situacioacuten la autoridad sanitaria deberiacutea organizar un estudio formal al respecto o en su defecto canalizar centralmente un registro de notificacioacuten obligatoria de casos de alteraciones neuroloacutegicas centrales atribuibles a deacuteficit de vitamina B12rdquo
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
Arch Intern Med 1979 Jan139(1)47-50
Macrocytosis mild anemia and delay in the diagnosis of pernicious anemiaCarmel R
Various factors led to delays of several months to several years in the diagnosis of pernicious anemia in 11 patients occasionally with serious consequences These cases illustrate that earlier diagnosis is possible with closer attention to abnormal results of common tests Macrocytosis detected by high mean corpuscular volume often preceded anemia but was not investigated especially when anemia was only slight Several cases demonstrated that vitamin B12 deficiency may initially produce only a mild macrocytic anemia which is maintained for a long period before a rapid worsening supervenes the reason for the latter acceleration of anemia is unknown Most serious was the evidence that mild anemias are often ignored Stricter attention to the established limits of normal hemoglobin values is required These aspects of physician performance have implication for the recognition of all anemias
Publication Types Case Reports
PMID 760683 [PubMed - indexed for MEDLINE]
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-
JOURNAL ARTICLE
Problems in the diagnosis and investigation of megaloblastic anemia
C M Shojania
The diagnosis of megaloblastic anemia and the differentiation of folate and vitamin B12 deficiency require in addition to careful attention to the history and physical findings the use of laboratory tests In this paper the commonly ordered tests for such a diagnosis are discussed with emphasis on the conditions that may cause false-positive or false-negative results in the complete blood count examination of a peripheral blood smear and a bone marrow specimen serum and erythrocyte folate assays serum vitamin B12 assays tests of vitamin B12 absorption and gastric analysis
Canadian Medical Association Journal Vol 122 Issue 9 999-1004 Copyright copy 1980 by Canadian Medical Association
- Paacutegina 1
- Paacutegina 2
- Paacutegina 3
- Paacutegina 4
- Paacutegina 5
- Paacutegina 6
- Paacutegina 7
- Paacutegina 8
- Paacutegina 9
- Paacutegina 10
- Paacutegina 11
- Paacutegina 12
- Paacutegina 13
- Paacutegina 14
- Paacutegina 15
- Paacutegina 16
- Paacutegina 17
- Paacutegina 18
- Paacutegina 19
- Paacutegina 20
- Paacutegina 21
- Paacutegina 22
- Paacutegina 23
- Paacutegina 24
- Paacutegina 25
- Paacutegina 26
- Paacutegina 27
-