carbono inicial
TRANSCRIPT
EL CARBONO, COMPONENTE ESENCIAL
DE LAS CÉLULAS
Mauricio morenobogota2016
Importancia del carbono
El Carbono permea todo el mundo viviente— desde la organización estructural de las células, pasando por los requerimientos energéticos, hasta la conservación de la información genética. El carbono es un condicionamiento para la existencia de la
biosfera .
Compuestos orgánicos
El Hidrógeno y otros elementos se unen covalentemente al carbono para formar en los seres vivos:
CarbohidratosLipidosProteínasAcidos nucleicos
El átomo de carbono
En su último nivel posee cuatro electrones; pudiendo tener 8.
Cada átomo de carbono puede unirse máximo con cuatro elementos compartiendo un par de electrones.
Los átomos de carbono se pueden unir formando
cadenas lineales, ramificadas o anillos.
La principal característica es su capacidad de unirse con otros átomos de carbono y de otros elementos y formar millones de compuestos.
Glucosa
DIFERENTES MODELOS DE LAMOLECULA DE HEMOGLONINA
Ball-and-stick model Space-filling model
Ribbon model
•Configuración electrónica del carbono
7
ORBITALES “S”
ORBITALES “P”
•Clasificación de orbitales híbridos:
• Orbitales hibridos sp
• Orbitales hibridos sp2
• Orbitales híbridos sp3
ORBITAL HÍBRIDO sp3•Cuando se mezcla un orbital “s” con
tres orbitales “p”, de la misma subcapa se forman 4 orbitales híbridos “sp3“
(ese pe tres).
ORBITALES HIBRIDOS
13
El átomo de carbono
METANO: LA SUSTANCIA ORGÁNICA MÁS SIMPLE.
Structural formula
Ball-and-stick model
Space-filling model
HH
H
H
C
ORBITAL HÍBRIDO sp2
Siempre que se mezcla cierto número de orbitales atómicos se obtiene el mismo número de orbitales híbridos. Cada uno de éstos es equivalente a los demás pero apuntan en dirección distinta. Cuando se mezclan un orbital “s” con dos orbitales
“p, se forman 3 orbitales híbridos “sp2.“
ORBITALES HIBRIDOS
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Orbital Híbrido “ sp“ • Esta hibridación ocurre cuando se
mezcla el orbital “s” y uno de los orbitales “p”, para generar dos
nuevos orbitales: Ejemplo BeF2
ORBITALES HIBRIDOS
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GRUPOS FUNCIONALESSon átomos o grupos de átomos que se unen covalentemente a una cadena carbonada dandole diferentes propiedades.
- CH3 Grupo metilo
Grupo Hidroxilo - OH
Grupo Amino - NH3+
Grupo Carboxilo- COOH
Grupo Fosfato- PO3-
Grupo Sulfhidrilo- SH
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HIDROCARBUROS
HIDROCARBUROS ALIFATICOS
ALCANOS
ETENO
ACETILENO
AROMATICOS
AROMATICOS
ALCOHOLES
ALCOHOLES
ALDEHIDOS Y CETONAS
ACIDOS CARBOXILICOS
ACIDOS CARBOXILICOS
ACILOS
ESTERES
ETERES
AMINAS
AMIDAS
FENOLES
NITRILOS
POLIFUNCIONALES
CARBOHIDRATOS
LIPIDOS
NUCLEOTIDOS
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Hidrocarburos• Compuestos de carbono e hidrogeno.
• Saturados (alcanos) los elementos unidos al carbono lo hacen a través de un enlace simple.
• Formula general [CnH2n+2] H C
H
H
C
H
H
H
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• Insaturados: Contienen enlaces carbono-carbono de tipo multiple (doble o triple)
H C
H
H
C
H
CH
H
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Alcanos: hidrocarburos saturados
• Hidrocarburos saturados, CnH2n+2 – “Saturados” porque ellos no pueden unir
más átomos de hidrogeno.
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Alcanos: hidrocarburos saturados • Hidrocarburos son moleculas compuestas de carbono
e hidrogeno.– Cada carbono forma cuatro enlaces químicos.– Un hidrocarburo saturado solo contiene enlaces sencillos
C – C y sus moléculas contienen el máximo número de átomos de H.
– Los hidrocarburos saturados son llamados ALCANOS
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Metano es una molécula tetraedrica
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Estructura de Lewis para el etano.
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Propano
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Butano
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Los 10 “Normales” AlcanosNameName FormulaFormula M.P.M.P. B.P.B.P. # Structural Isomers# Structural Isomers
• Methane CH4 -183 -162 1
• Ethane C2H6 -172 -89 1
• Propane C3H8 -187 -42 1
• Butane C4H10 -138 0 2
• Pentane C5H12 -130 36 3
• Hexane C6H14 -95 68 5
• Heptane C7H16 -91 98 9
• Octane C8H18 -57 126 18
• Nonane C9H20 -54 151 35
• Decane C10H22 -30 174 75
C1 - C4 are Gases C1 - C4 are Gases at Room Temperatureat Room Temperature
C5 - C16 are Liquids C5 - C16 are Liquids at Room Temperatureat Room Temperature
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Reglas de la IUPAC para nombrar alcanos
• Nombrar la cadena principalNombrar la cadena principal• Numerar los átomos de carbono de la cadena Numerar los átomos de carbono de la cadena
principal empezando por el más cercano a las principal empezando por el más cercano a las ramificacionesramificaciones
• Nombrar las ramificaciones con la teminación ilo, Nombrar las ramificaciones con la teminación ilo, ejemplo metilo, etilo, propilo etc.ejemplo metilo, etilo, propilo etc.
• Cuando hay más de una ramificación nombrarlas en orden alfabetico
• Finalmente usar prefijosprefijos para indicar multiples ramificaciones.
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Reglas de la IUPAC para nombrar alcanos
1. Para alcanos después del butano, agregar-ano a la raíz griega del número de átomos de carbonos de la cadena más larga .
C-C-C-C-C-C : hexano2. Sustituyentes alquilo: cambiar-ano por
-ilo. -C2H5 es el etilo.
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Reglas de la IUPAC para nombrar alcanos
3.La posición de los sutituyentes se especifica con la numeración.
C C-C-C-C-C-C
3-metil-hexano Empezar desde el extremo más cercano
a la numeración.4. Nombrar los sutituyentes en orden
alfabetico y usando los prefijos di-, tri- etc.
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Isomeros estructurales• Isomeros: moléculas que
tienen la misma formula molecular, pero diferente formula estructural CH3
CH2CH2
CH2CH3
CH3
CH2CH
CH3
CH3
n-pentano, C5H12
2-metilbutano, C5H12
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Ejemplo : 2,2-dimetilpentano2,2-dimetilpentano
heptanoheptano
CH31
CCH23
CH24
CH35
CH3
CH3
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Ejemplo: 3-etil-2,4-dimetilheptano3-etil-2,4-dimetilheptano
3-etil-5-metiloctano
CH3
CHCH
CHCH2
CH2CH3
CH2CH3
CH3 CH3
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Reacciones de los alcanos
• Reacciones de combustion 2C4H10 + 13 O2 8CO2 + 10 H2OReacciones de sustituciónReacciones de sustitución
CHCl Cl CCl HClh3 2 4
CH4 + Cl2 CH3Cl + HCl
CH3Cl + Cl2 CH2Cl2 + HCl
CH2Cl2 + Cl2 CH Cl3 + HCl
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Reacciones de deshidrogenaciónReacciones de deshidrogenación
CH3CH3 CH2 CH2 + H2
Etileno
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Ciclo alcanosCiclo alcanos
• Formación de anillos, CnH2n
CH3
CH2CH3 CH2
CH2
CH2
n-propaneC3H8
cyclopropaneC3H6
60° bond angleunstable!!
109.5° bond angle
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Ciclohexano –conformaciones de silla y bote• El Ciclohexano no es una molécula plana. • El bote y la silla (99%) son dos conformaciones
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Alquenos y alquinos
Alquenos: hidrocarburos que contienen dobles enlaces carbono-carbono. [CnH2n]
C=C EtenoCC=C propeno
Alquinos: hidrocarburos que contienen u triple enlace carbono-carbono. [CnH2n-2]
C C EtinoCCCCC 2-pentino
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Nomenclatura para los Alquenos
1.La cadena principal debe contener el doble enlace, al nombarla debe terminar en -eno
C2H4; CH2=CH2 eteno
2. Cuando hay más de tres carbonos, el doble enlace se indica con el número con el número más bajo del carbono del enlacemás bajo del carbono del enlace C=CCC 1-buteno
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Isomeros de los Alquenos:Cis y Trans
El doble enlace no permite los giros alrededor del mismo.
CH3 CH3 CH3
CH = CH CH = CH
cis trans CH3
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Reacciones de adición
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Hidrogenación
H H H H Ni
H–C=C–H + H2 H–C–C–H
H H
eteno etano
CHCH33-CH-CH33
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Halogenacion
H H H H
NiH–C=C–H + Cl2 H–C–C–H
Cl Cl
eteno dicloroetano
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Reacciones de Halogenación
CH2 CHCH2CH2CH2 + Br2
CH2Br CHBrCH2CH2CH2
1,2-dibromopentano
1-penteno
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Alquinos, CnH2n–2
Triple enlace Carbono-carbono Nombres terminados en -ino
HCCH etino(acetileno)
HCC-CH3 propino
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1 2 3 4
CH2=CHCH2CH3 1-buteno
CH3CH=CHCH3 2-buteno
CH3CHCHCH3 2-butino
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Preguntas
Cuál es el nombre de los siguientes compuestos:
A. CH3CH2CCCH3
CH3
B. CH3C=CHCH3
2-pentino
2-metil-2-buteno
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Preguntas
c.
CH3CH2C CCHCH2CH3CH2CH3
1 2 3 4 5 6 7
5-etil-3-heptino
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Hidrocarburos aromaticos
• Ciclos que contienen enlaces sencillos y dobles alternados. – Se llaman “aromaticos” (por el aroma
que generan).– La presencia de la alternacia de
enlaces sencilos y dobles le confiere propiedades particulares como participar en reacciones de sustitución y no de adición.
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Estructuras de Lewis para el benceno
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Benzene C6H6
sp2
sp2sp2
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Shorthand notation for benzene rings
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The bonding in the benzene ring is a combination of different Lewis structures.
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REACCIONES DE SUSTITUCION DEL BENCENO
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Nomenclatura de los derivados del benceno
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Sistemas Aromaticos más complejos
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Halogenuros de alquilo
Son alcanos en los cuales un hidrogeno ha sido reemplazado por un halogeno(F, Cl, Br, or I)
CH3Br bromometano BrCH3CH2CHCH3 2-bromobutano
Cl clorociclobutano
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Nomenclatura
bromociclopentano
1,3-diclorociclohexano
Br
Cl
Cl
1 2 3
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Nomenclatura
El nombre del siguiente compuesto es:Cl CH3
CH3CH2CHCH2CHCH3
1) 2,4-dimetilhexano2) 4-cloro-5-metilhexano3) 4-cloro-2-metilhexano
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Alcoholes: R–OH • El grupo hidroxilo –OH hace al alcohol polar
y puede formar puentes de hidrogenopuentes de hidrogeno. Lo Lo hace soluble en aguahace soluble en agua
• El Etanol es producto de la fermentacion
yeastC6H12O6
Glucosa2CH3CH2OHEtanol + 2 CO2
CO + 2H2O CH3OH Metanol
• El metanol es producto de la hidrogenacion industrial del monoxido de carbono
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Usos de los alcoholes• Metanol es usado para la síntesis de
adhesivos, fibras, plasticos y combustble para motor.
• El metanol es toxico para los humanos y puede causar ceguera y muerte.
• El Etanol se le adiciona a la gasolina para formar gasohol. Es usado como solvente.
• Producción comercial del etanol: CH2=CH2 + H2O CH3CH2OH
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Clases de alcoholes
R CH2OH Primary alchol
CHOHR'R
Secondary alcohol
CR'R
R"OH Tertiary alcohol
Los alcoholes se pueden clasificar de acuerdo al numero de carbonos unidos al carbono dondenumero de carbonos unidos al carbono donde esta el grupo –OH.
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Nombrando los Alcoholes
En la IUPAC la terminación ano del alcano es reemplazada por -ol.
CH4 metano
CH3OH metanol (alcohol metilico)
CH3CH3 etano
CH3CH2OH etanol (alcohol etilico)
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OH
Phenol(Aromatic alcohol)
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CH3CH2CH2OH 1-propanol
OH CH3CHCH3 2-propanol
CH3 OH CH3CHCH2CH2CHCH3 5-metil-2-hexanol5 2
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OH CH3CHCH3
2-propanol (alcohol isopropilico)
HO-CH2-CH2-OH
1,2-etanodiol1,2-etanodiol (etilenglicol) OH
glicerol HO-CH2-CH-CH2OH
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A. OH
CH3CHCHCH2CH3
CH3
OHB.
3-metil-2-pentanol
Ciclobutanol
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Reacciones de los alcoholes
CombustionCH3OH + 2O2 CO2 + 2H2O + Energía
Deshidratacion H OH calor H-C-C-H H-C=C-H + H2O
H H H H alcohol alqueno
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Ethers
• Contain an -O--O- between two carbon groups• Simple ethers named from -yl names-yl names of the
attached groups and adding adding etherether.
CH3-O-CH3 dimethyl ether
CH3-O-CH2CH3 ethyl methyl ether
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Aldehydes and Ketones
In an aldehyde, an H atomH atom is attached to a carbonyl group
O carbonyl group CH3-C-HIn a ketone, two carbon groupstwo carbon groups are attached to
a carbonyl group O carbonyl group
CH3-C-CH3
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Naming Aldehydes
IUPAC Replace the -e in the alkane name -alCommon Add aldehyde to the prefixes form
(1C), acet (2C), propion(3), and butry(4C) O O O
H-C-H CH3-C-H CH3CH2C-H
methanal ethanal propanal(formaldehyde) (acetaldehyde) (propionaldehyde)
methaneethane propane
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Aldehydes as Flavorings
CHO
CHO
HOOCH3
CH=CH CHO
Benzaldehyde Vanillin Cinnamaldehyde(almonds) (vanilla beans) (cinnamon)
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Naming Ketones
In the IUPAC name, the -e in the alkane name is replaced with -one
In the common name, add the word ketone after naming the alkyl groups attached to the
carbonyl group O O
CH3 -C-CH3 CH3-C-CH2-CH3
Propanone 2-Butanone (Dimethyl ketone) (Ethyl methyl ketone)
O
Cyclohexanone
Acetone
propane butane
cyclohexane
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Preparation of aldehydes and Ketones
They are produced by oxidation of alcohols:
CH3CH2OH Oxidation
CH3CHCH3
OH
Oxidation CH3CCH3O
CH3CO
Hacetaldehyde
acetone
Primary alcohol
Secondary alcohol
ethanal
propanone
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Question
Classify each as an aldehyde (1), ketone (2) or neither(3).
O
A. CH3CH2CCH3 B. CH3-O-CH3
CH3 O C. CH3-C-CH2CH D.
CH3
O
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Solution
Classify each as an aldehyde (1), ketone (2) or neither(3).
O
A. CH3CH2CCH3 2 B. CH3-O-CH3 3 CH3 O
C. CH3-C-CH2CH 1 D. 2 CH3
O
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Question
Name the followingO
A. CH3CH2CCH3 B. CH3 O C. CH3-C-CH2CH
CH3
O
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Solution
O
A. CH3CH2CCH3 B.2-butanone (ethyl methyl ketone)
CH3 O C. CH3-C-CH2CH
cyclohexanone CH3
2,2-dimethylbutanal
O
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Question
Draw the structural formulas for each:
A. 3-Methylpentanal
B. 2,3-Dichloropropanal
C. 3-Methyl-2-butanone
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Solution Draw the structural formulas for each:
CH3 O A. 3-Methylpentanal CH3CH2CHCH2CH
Br O
B. 2,3-Dibromopropanal Br-CH2CHCH
O
C. 3-Methyl-2-butanone CH3CHCCH3
CH3
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Carboxylic Acids and Esters Carboxyl Group
Carboxylic acids contain the carboxyl group as carbon 1.
O R
CH3 — C—OH : CH3—COOH
carboxyl group
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Naming Carboxylic Acids
Formula IUPAC Common alkan -oic acid prefix – ic acid
HCOOH methanoic acid formic acid
CH3COOH ethanoic acid acetic acid
CH3CH2COOH propanoic acid propionic acid
CH3CH2CH2COOH butanoic acid butyric acid
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Naming Rule for Carboxylic acids
• Identify longest chain• (IUPAC) Number carboxyl carbon as 1carboxyl carbon as 1 CH3
|CH3 — CH—CH2 —COOHIUPAC 3-methylbutanoic acid
1234
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Question
Give IUPAC name:
A. CH3COOH
CH3
|
B. CH3CHCOOH
2
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Solution
A. CH3COOH ethanoic acid; acetic acid
CH3
|
B. CH3CHCOOH 2-methylpropanoic acid;
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Preparation of carboxylic acids
• Oxidation of primary alcohols
CH3CH2OH CH3COOHKMnO4
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Reaction of carboxylic acid with alcohol
CH3CO
OH + H OCH2CH3
CH3CO
OCH2CH3 + H2O
Ester
Carboxylic acid Alcohol
Esterification
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Esters
In a ester, the H in the carboxyl group is replaced with an alkyl group
O
CH3 — C—O —CH3 : CH3—COO —CH3
ester group
•Esters give fruity odors
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Naming Esters
• The parent alcohol is named first with a –yl ending
• Change the –oic ending of the parent acid to –ate
acid alcohol O methylCH3 — C—O —CH3
Ethanoate methyl ethanoate (IUPAC)(acetate) methyl acetate (common)
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Some esters and their names
Flavor/OdorRaspberries
HCOOCH2CH3 ethylmethanoate (IUPAC)ethylformate (common)
PineapplesCH3CH2CH2 COOCH2CH3
ethylbutanoate (IUPAC)ethylbutyrate (common)
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QuestionGive the IUPAC and common names of the following compound, which is responsible for the flavor and odor of pears.
O CH3 — C— O —CH2CH2CH3
153
Solution
O propyl
CH3 — C—O —CH2CH2CH3
propylethanoate (IUPAC)propyl acetate (common)
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Question
Draw the structure of the following compounds:
A. 3-bromobutanoic acid
B. Ethyl propionoate
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Solution
A. 3-bromobutanoic acid Br |
CH3CHCH2COOH
B. Ethyl propionoate O CH3 CH2 COCH2CH3 CH3CH2COOCH2CH3
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Hydrolysis of esters
• Esters react with water and acid catalyst• Split into carboxylic acid and alcohol
O H+
H — C—O—CH2CH3 + H2O
O
H — C—OH + HO—CH2CH3
-OHH
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Amines• Organic compounds of nitrogen N;
derivatives of ammonia• Classified as primary, secondary, tertiary
CH3 CH3
CH3—NH2 CH3—NH CH3—N — CH3
Primary Secondary Tertiary one N-C two N-C three N-Cbond bonds bonds
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Naming Amines
IUPAC aminoalkane Common alkylamineCH3CH2NH2 CH3—NH —CH3
aminoethane N-methylaminomethane(ethylamine) (dimethylamine)
NH2
|CH3CHCH3
2-aminopropane Aniline N-methylaniline(isopropylamine)
NH2 NH CH3
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Question
Give the common name and classify:
A. CH3NHCH2CH3
CH3
|B. CH3CH2NCH3
160
Solution
A. CH3NHCH2CH3
ethylmethylamine, (Secondary)
CH3 |B. CH3CH2NCH3
ethyldimethylamine, (Tertiary)
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Question
Write a structural formula for
A. 2-aminopentane
B. 1,3-diaminocyclohexane
162
Solution
A. 1-aminopentane CH3CH2CH2CH2CH2-NH2
B. 1,3-diaminocyclohexane
NH2
NH2
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PolymersPoly= many; mers=parts
• Polymers are large, usually chainlike molecules that are built from small molecules called monomers joined by covalent bonds
Monomer PolymerEthylene PolyethyleneVinyl chloride Polyvinyl
chlorideTetrafluoroethylene Teflon
164
Some common synthetic polymers, their monomers and applications
165
Types of Polymerization
Addition Polymerization:Addition Polymerization: monomers “add together” to form the polymer, with no other products. (Teflon)
Condensation Polymerization:Condensation Polymerization: A small molecule, such as water, is formed for each extension of the polymer chain. (Nylon)
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Addition Polymerization
OH
C CHH
HH
COH
H CH
H
H
C CHH
HH
COH
H CH
H
H
COH
H CH
H
HC CH H
H H
The polymerization processIs initiated by a free radical
A species with an unpaired electron such as hydroxyl free radical
Free radical attacks and breakThe bond of ethylene moleculeTo form a new free radical
• Repetition of the process thousands of times creates a long chain polymer• The process is terminated when two radicals react to form a bond; thus there will be no free radical is available for further repetitions.
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Condensation PolymerizationFormation of Nylon
NH
H(CH2)6 N
H
H CO
O (CH2)4H CO
O HHexamethylendiamine Adipic acid
NH
H(CH2)6 N
HC (CH2)4 C
O
O H
O+ H2O
• Small molecule such as H2O is formed from each extension of the polymer chain• both ends are free to react
Dimer
Diamine Dicarboxylic acid
168
NH
(CH2)6 NH
( C (CH2)4 COO
)n
Nylon
169
Proteins
• Natural polymers made up of -amino acids (molecular weight from 6000 to >1,000,000 g/mol).
1. Fibrous Proteins: provide structural integrity and strength to muscle, hair and cartilage.
170
Proteins
2. Globular Proteins: Roughly spherical shape Transport and store oxygen and
nutrients Act as catalysts Fight invasion by foreign objects Participate in the body’s regulatory
system Transport electrons in metabolism
171
-Amino Acids
NH2 always attached to the -carbon (the carbon attached to COOH)
•C = -carbon
H2N C
H
COOH
R
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Bonding in -Amino Acids
• + H2O
•
A peptide linkage (amide group)
•There are 20 amino acids commonly found in proteins.• Additional condensation reaction produces polypeptide eventually yielding a protein
CNH
H
H
R
C
O
N
H
C
H
R'
CO
OHDipeptide
• The protein polymer is built by condensation reaction between amino acids
173
The 20 Alpha-amino Acids found in most proteins
174
Levels of Structure•Primary: Sequence of amino acids in the protein chain. (lycine-alanine-leucne: (lys-ala-leu).
– So many arrangements can be predicted.
Tripeptide containing Glycine, Cysteine, and Alanine
175
Levels of Structure•Secondary: The arrangement of the protein chain in the long molecule (hydrogen bonding determines this).• Hydrogen bonding between lone pairs on an oxygen atom in the carbonyl group of an amino acid and a hydrogen atom attached to a nitrogen of another amino acid
C O NH
This type of interaction can occur with the chain coils to form a spiral structure called - helix- helix
176
Hydrogen bonding within a protein chain causes it to form a stable helical structure called the alpha-Helix
This is found infibrous protein likewool and hair givingit the elasticity
177
•Tertiary: The overall shape of the protein (determined by hydrogen-bonding, dipole-dipole interactions, ionic bonds, covalent bonds and London forces).
Summary of the Various Types of Interactions that Stabilize the Tertiary Structure of a Protein: (a) Ionic, (b) Hydrogen Bonding, (c) Covalent, (d) London Dispersion, and (e) Dipole-Dipole
178
Summary of the Various Types of Interactions that Stabilize the Tertiary Structure of a Protein: (a) Ionic, (b) Hydrogen Bonding, (c) Covalent, (d) London Dispersion, and(e) Dipole-Dipole
179
CarbohydratesCarbohydrates
Food source for most organisms and structural material for plants.Empirical formula = (CH2O)n Most carbohydrates such as starch and cellulose are polymers of monosacharides or polymers of monosacharides or simple sugar monomerssimple sugar monomersMonosaccharides (simple sugars) are polyhydroxy ketones and aldehydes
Pentoses (5-carbon atoms) - ribose, arabinoseHexoses (6-carbon atoms) - fructose, glucose
180
Some Important Monosaccharides
181
Chiral carbon atoms in fructose
• Molecules with nonsuperimposable mirror images exhibit optical isomerism
• A carbon atom with different groups bonded to it in a tetrahedral arrangement always has a nonsuperimposable mirror images which gives rise to a pair of optical isomers
182
Tetrahedral Carbon atom with four different substituents cannot have its mirror image superimposed
183
The Mirror Image Optical Isomers of Glyceraldehyde
* Chiral carbonatom
184
Fructose
D-Fructose
H2OHC
C
CHO H
C
O
H OH
C
CH2OH
OHH
**
*
There are 3 chiralCarbon atomsThere are 23 isomersThat differ in the abilityTo rotate light
185
Complex carbohydrates
Disaccharides (formed from 2 monosaccharides joined by a glycoside linkage)
sucrose (glucose + fructose)
Polysaccharides (many monosaccharide units)
starch, cellulose
186
Sucrose is a disaccharideformed from alpha-D-glucose and fructose
187
)a (The Polymer Amylose is a Major Component of Starch and is Made Up of Alpha-D-Glucose Monomers (b) The Polymer Cellulose, which Consists of Beta-D-Glucose Monomers
188
Nucleic Acids• Life is possible because each cell when it
divides can transmit the vital information about how it works to the next generation
• The substance that stores and transmits information is a polymer called deoxyribonucleic acid (DNA)
• DNA together with other similar nucleic acids called ribonucleic acids is responsible for the synthesis of various proteins needed by the cell to carry out its life functions
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Nucleic Acids
• DNA (deoxyribonucleic acids): stores and transmits genetic information, responsible (with RNA) for protein synthesis. (Molar mass = several billion)•RNA (ribonucleic acid): helps in protein synthesis. (Molecular weight = 20,000 to 40,000)
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Monomers of nucleic acidNucleotides
1. Five-carbon sugar, deoxyribose in DNA and ribose in RNA.
2. Nitrogen containing organic base 3. Phosphoric acid molecule, H3PO4
• The base and the sugar combine to form a unit that in turn reacts with phosphoric acid to create a nucleotide• The nucleotides become connected through condensation reaction that eliminate water to give a polymer that contain a billion units.
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The Organic Bases Found in DNA and RNA
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The base and sugar combine to form a unit that in turn reacts with phosphoric acid to create the nucleotide, which is an ester
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A Portion of a typical nucleic acid chain
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Double helix formation• According to Watson and Crick (Nobel prize
winners), CAN is composed of two strands (threads) running in opposite directions that are bridged by hydrogen bonds between specific pyrimidine groups on one strand and purine group on the other
• The two strands are twisted into a double -helix structure
• The strongest hydrogen bonds form between adonine and thymine and between guanine and cystosine. Thus; A-T or G-C bonding interactions will take place
• The sequence of nucleotides on one strand of the double helix determines the sequence of the other
• The sequence of the bases determines what information is stored.
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)a (The DNA double helix contains two sugar-phosphate backbones, with the bases from the two strands hydrogen bonded to each other; the complementarity of the (b) thymine-adenine and (c) cytosine-guanine pairs
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Gracias