moléculas que reconocen antígenos

7/23/2019 Molculas que reconocen antgenos

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VMOPF^ZOCEC EVSMGDE CF ZOMEHGE

@ejuhtec cf Jofmjoes Uudojg Noghbojes

Omdumghgboe

Cr. Ajtgr Zedufh Hpfz Dgrfmg Brupg :*>

Jedejag Vrfte Fhose Emeh | Jghm Gifce Erturg | Fspomgze Dgrehfs Hhuvoe Nrosfoce

Iurfbuo Dgmrfeh Dmoje | Hpfz Juhher Dere Jgmjfpjom | Zghos Dfcremg Zohvoe Jerghome


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Zustemjoe quf pufcf sfr rfjgmgjoce pgr hgsrfjfptgrfs cf hgs hom`gjotg N y S y pgr hes jhuhesprfsfmtecgres cf emtbfmgs.

Sednom sgm hhedecgs omdumbfmgs, quf sfpufcfm rfjgmgjfr pgr hgs rfjfptgrfs cfomdumgbhgnuhome cf hes jhuhes N g S, juemcg`grdem um jgdphfig jgm fh DAJ (Jgdphfig deygrcf aostgjgdpetonohocec).

Zo nofm tgcgs hgs omdumbfmg s sg m emtbfmgs,

mg tgcgs hgs emtbfmg s sgm omdumbfmgs .

EMSBFMGZ


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JE^EJSF^ZSOJEZ CFH EMSBFMG

Grobfm

Cgsos

Jgdphfiocec cf he dghjuhe

Sedeg

Brupgs qudojgs

Jgm`oburejom ptoje

Jerbe fhjtroje

Omdumgbfmojocec

Emtobfmojocec


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JHEZO@OJEJOM9

Qfmgemtbfmgs

Aehgemtbfmgs

Fptgpg

^fbogmfs jgm ejtovocecomdumghboje cf um emtbfmg qufsf umfm e rfjfptgrfs cfdfdnreme fspfj`ojgs fm hgshom`gjotgs g e hgs emtojufrpgs

sfjrftecgs..

SO\GZ CF EMSBFMGZ9

Fxbfmgs

Fmcbfmgs

Eutg emtbfmgs


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Fh NJ^ fs fh rfjfptgr cf hom`gjotgs Nquf sf fmjufmtre emjhecg fm hedfdnreme cf hgs hom`gjotgs N.

Fh NJ^ fs he moje dghjuhe jepez cfrfjgmgjfr fspfj`ojedfmtf fh Eb. Hepertf veroenhf cfh rfjfptgr cfh hom`gjotgN he jgmstotuyf he dghjuhe cf Objgdphfte quf sf omsfrte fm hedfdnreme e trevs cf hes cgsjecfmes pfseces.

He jecfme fs jgdm pere tgces heomdumgbhgnuhomes cf supfr`ojof.

^FJF\SG^ CF HOM@GJOSGZ N(NJ^)


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\rgho`frejom co`frfmjoejomdfcoemtf fh rfjgmgjodofmtgemtobmojg


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Vm hom`gjotg Nfstoduhecg pgr um emtbfmg jednoe su fstrujture y `umjom. Fhhom`gjotg N sf covocf prgcujofmcg verogs jhgmfs, pgstfrogrdfmtf sf trems`grde,cfserrghhemcg rftjuhg fmcgphsdojg rubgsg, `grdmcgsf `omehdfmtf ume jhuhe

phesdtoje.

@umjogmfs f`fjtgres


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EMSOJVF^\GZ

Hgs emtojufrpgs g omdumgbhgnuhomes, sgm bhujgprgtfmes `grdeces pgr fhgrbemosdg jgdg rfspufste cfh sostfde omdumghbojg `rfmtf e sustemjoesfxtrees, fs cfjor, emtbfmgs fm fh quf hgs prodfrgs rfejjogmermfspfj`ojedfmtf jgmtre stgs.

@umjogmfs

^fjgmgjodofmtg emtobmojg

Ejtovejom cf dghjuhes f`fjtgres


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Vme jecfme pfsece (A), juyg pfsggsjohe fm 6< kCe y ume jecfme hobfre(H) cf tem sghg >6 kCe.

Fm hgs fxtrfdgs sf sotem rfbogmfsquf verem ume e hes gtres, fs cfjor,hes rfbogmfs veroenhfs (P).

Dofmtres quf fh jufrpg rfstemtf, fs hepertf quf omtfrejjogme jgm hesdghjuhes y jhuhes f`fjtgres,hhedecg es rfbom jgmstemtf (J).


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Vm borg ds

Enofrtg


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Dfcoemtf fmzodes prgtfghtojes sf aejf rf`frfmjoe e ume `rejjom jrostehozenhfy gtre pfrg cf umom eh emtbfmg (@j y @en rfspfjtovedfmtf) fstg, pgr herupture quf rfehozem pgr dfcog cf he cobfstom. Es, fifdphgs jgdg pepeme ypfpsome aerm jgrtf costomtg eh emtojufrpg fmtfrg

\epeme

\fpsome


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Fxprfsom cf omdumgbhgnuhomes curemtf he decurejom cf

jhuhes N


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He smtfsos cf hes jecfmes hobfres y pfseces cf hes omdumgbhgnuhomes fstrfbuhece pgr jrgdgsgdes costomtgs.


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Fm fste smtfsos pertojopem verogs sfbdfmtgs cf bfmfs quf jgdnomecgs cemhuber e hgs bfmfs `umjogmehfs rfspgmsenhfs cf he jgco`ojejom cf hes jecfmes

cf hes omdumgbhgnuhomes.


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^fgrcfmedofmtg cf bfmfs cf jecfmes hobfres


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^fgrcfmedofmtg cf bfmfs cf jecfmes pfseces


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Dfjemosdg cf fhodomejom cf hgs bfmfs quf mg sf tremsjronormpere he `grdejom cf he mufve jecfme


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Vmom cf sfbdfmtgs cf bfmfs

^fbhe 5>/>:


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@esfs `omehfs cf he smtfsos cf omdumgbhgnuhomes


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Osgtopgs9 Fstrujture y `umjogmfs


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Fm hgs cgdomogs PA y PH pufcfm ocfmto`ojersf trfs sfbdfmtgs cfveroenohocec fspfjoehdfmtf fhfvece, fs cfjor, rfbogmfs aopfrveroenhfs qufsf cfsobmem jgdg AP5, AP> y AP: sofmcg fste htode he dsaopfrveroenhf.


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@ufrze mg jgvehfmtf Grobfm


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@ufrze mg jgvehfmtf

Grobfm

@ufrzes fhfjtrgfsttojes Etrejjom fmtrf jerbes gpufstes.

\ufmtfs cf aocrbfmg

tgdg cf aocrbfmg jgdpertocgfmtrf cgs tgdgsfhfjtrgmfbetovgs.

@ufrzes cf vem cfr ReehsHes `hujtuejogmfs fm hes munfsfhfjtrmojes cf hes dghjuhes

pgherozem hgs tgdgs vfjomgs.

@ufrze aocrg`nojesBrupgs aocrg`nojgs omtfrejjogmemjgm ebue y tofmcfm e

fdpequftersf iumtgs pere fxjhuorhes dghjuhes cf ebue. Heetrejjom tednom odphoje hes

`ufrzes cf vem cfr Reehs.


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^FJF\SG^ CF HEZ JHVHEZ S(SJ^)

Fh rfjgmgjodofmtg emtobmojg jgdg umpfqufg `rebdfmtg pfptcojg umocg e he

dghjuhe cf DAJ y prfsfmtecg fm hesupfr` oj of jfhuher fs ume cf hesjerejtfrstojes costomtoves cf hes jhuhes S.

Fxostfm odpgrtemtfs co `frfmjoes fmtrf hgs

rfjfptgrfs S y hes omdumgbhgn uh omes, quf

rf`hfiem hes jerejtfrstojes fspfjoehfs cfrfjgmgjodofmtg cfh emtbfmg pgr fh rfjfptgr cfjhuhes S y su eh te cf um jogmfs f`fjtgres.


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Cfh dosdg dgcg quf hgs hom`gjotgs S fxprfsem fm su supfr`ojofprgtfmes JC3 y JC1

Dghjuhe @umjom


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DghjuheEjjfsgroe

@umjom

JC36 Ejtovocec torgsome `gsètese; sf fmjufmtre fm hgs pesgs omojoehfscf SJ^ cf sfehozejom; fs mfjfseroe pere fh ejgphedofmtg cfhSJ^.

JC>1 Zf umf cgs dghjuhes costomtes cf he supfròjof jfhuher, N2.5 yN2.>, quf sf fmjufmtre fm hes jhuhes cfmcrtojes, hgs dejrèbgsy hes jhuhes N ejtoveces.

JSHE-3 Zf umf e he E\J; fmve sfehfs omaonotgroes e hes jhuhes S.

JC>

Dghjuhe cf ecafsom y fh tremscujtgr cf he sfeh; eyuce pereebrfber fh SJ^ fm hes rfbogmfs cf jgmtejtg jhuhe-jhuhe, hg qufpfrdotf he fstenohozejom cf neie eòmocec SJ^ / DAJomtfrejjogmfs; Odphojecg fm he rfbuhejom cf he prgcujjom cfjotgjomes pgr S

OmtfbromesDfcoem fm he ecafsom e hes J\E, hes jhuhes fmcgtfhoehfs, yprgtfmes cf detroz fxtrejfhuher

JC:Fsf jgdphfig cf dfdnreme SJ^9JC: fs rfqufroce pere hefstenhf omtfrejjom cf hes jhuhes S jgm jhuhes prfsfmtecgre cf

emtbfmgs .


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Jece rfjfptgr S fs fspfj`ojg cf ume jgdnomejom cftfrdomece cfpptocg y dghjuhes cf DAJ prgpoe.

Fxprfsom cf veroemtfs cf DAJ (Odpgrtemtfs pere covfrsocec cfrfjgmgjodofmtg cfh SJ^).

DAJ jhesf O

-Cgdomogs phfbecgs cf 5 y >-

Vmfm pptocgs jgrtgs cf 1 e 5


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DAJ jhesf OO

-Cgdomogs mg phfbecgs cf 5 y 5-

Vmfm pptocgs cf 50 e 51

edomgjocgs pgr sus cgs fxtrfdgs.

Hgs sotogs jgm promjopeh pghodgr`osdg fstm hgjehozecgs fm heafmcocure cf umom eh pptocg.

Ednes, tofmfm quf sfr jepejfs cf umor cf demfre fstenhfmudfrgsgs pptocgs co`frfmtfs.


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^FJGMGJODOFMSG \G^ HGZ HOM@GJOSGZ S CF VMJGD\HFIG \\SOCG-DAJ


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JEÊJSF^ZSOJEZ CF HEZ OMSFÊJJOGMFZ \\SOCG-DAJ

Jece dghjuhe cfh DAJ cf jhesf O g OO prfsfmte ume moje afmcocure cfumom e pptocgs quf pufcf ehnfrber dujags pptocgs co`frfmtfs.

Hgs pptocgs quf sf umfm e dghjuhes cfh DAJ jgdpertfm jerejtfrstojesfstrujturehfs quf èjohotem fste omtfrejjom.

He esgjoejom cf pptocgs emtobmojgs y dghjuhes cfh DAJ fs umeomtfrejjom seturenhf, cf neie eòmocec jgm ume vfhgjocec cf esgjoejom hfmtey ume vfhgjocec cf cosgjoejom duy hfmte.

He umom cf pptocgs e hes dghjuhes cfh DAJ fs ume omtfrejjom mgjgmstemtf dfcoece pgr rfsocugs temtg fm hgs pptocgs jgdg fm hesafmcocures cf hes dghjuhes cfh DAJ.

Jerejtfrstojes DAJ cf jhesf O DAJ cf jhesf OO


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JE^EJSF^ZSOJEZ CF HEZ DGHJVHEZ CFH DAJ CF JHEZF O _ OOJerejtfrstojes DAJ cf jhesf O DAJ cf jhesf OO

Jecfmes pghopfptcojes (33-32 kC)

>-dojrgbhgnuhome (5> kC) (:>-:3 kC) (>?-:> kC)

Hgjehozejom cf

edomgjocgs pghodgr`gs Cgdomogs 5 y > Cgdomogs 5 y 5

\umtg cf umom pere fhjgrrfjfptgr cf hgs

hom`gjotgs S

^fbom :sf umf e JC1 ^fbom > sf umf e JC3

Sedeg cf he afmcocurequf sf umf e hgs pptocgs

Zf ejgdgce e pptocgscf 1-55 edomgjocgs

Zf ejgdgce e pptocgs cf5K, A->C, A->H

AHE-C^, AHE-CU, AHE-C\O-E, O-F

Jhuhes N Jhuhes S


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Jhuhes N Jhuhes S

Vmom jgm fh Eb Nomeroe9 Eb-Ej Sfrmeroe9 SJ^-Eb-DAJ

Zf umfm e Eb sghunhf7 ZO MG

^fquofrf DAJ7 MG ZO

Fstrujture cfh Eb trocodfmsogmeh Nocodfmsogmeh

Meturehfze qudoje cfhfpotgpg

\rgtfme, pghosejrocg,hpocg, ejocg mujhfojg

\rgtfme

\rgpofcecfs cfh fpotgpg\ertf fxtfrme, ejjfsonhf,

aocr`ohg sfjufmjoeh gjgm`grdejogmeh

\ertf omtfrme,cfsmeturehozece, em`opetojg,pfptocg homfeh, umocg eh DAJ


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^F@F^FMJOEZ NONHOGB^@OJEZ

ENNEZ, Enuh K. y Emcrfw A. Hojatdem. Omdumghgbe Jfhuher y Dghfjuher. FcotgroehFhsfvofr Zeumcfrs. Uuomte fcojom >

moléculas que reconocen antígenos

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