Reactions 1464, p22 - 10 Aug 2013

SEtoricoxib

Fixed drug eruption in an elderly patient: casereport

A 90-year-old man developed fixed drug eruption whilereceiving etoricoxib.

The man had been receiving etoricoxib 60mg [route andfrequency not stated] or articular pain over a 5-month period.He was subsequently admitted with pruritic, hyperpigmentedround plaques with erythematous borders and occasionalcentral erosion, affecting his left inguinal, posterior thoracicand right leg. He had experienced similar lesions on fouroccasions in the 5 months preceding admission [time to onsetnot clearly stated]; the lesions had healed, withhyperpigmentation, in about 10 days. Skin biopsy supported adiagnosis of bullous-type drug eruption; lymphocytetransformation test was positive for etoricoxib.

Etoricoxib was withdrawn and he was advised to avoid thedrug. He received topical corticosteroids and antihistaminesover 14 days and his condition improved.

Against advice, the man subsequently took three doses ofetoricoxib 60mg; his existing skin lesions worsened and hedeveloped additional lesions. He received treatment andachieved a good outcome after 12 days.

Author comment: "[T]he infrequent occurrence of [fixeddrug eruption] induced by etoricoxib should be taken intoaccount even in elderly patients, especially in the setting of itsincreasing use in pain control."Giurcaneanu C, et al. Fixed drug eruption induced by etoricoxib in an elderlypatient. Allergy 67: 399-400, Nov 2012. Available from: URL: http://dx.doi.org/10.1111/all.12036 [abstract] - Romania 803090976

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Reactions 10 Aug 2013 No. 14640114-9954/13/1464-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved