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Benzodiazepinas
Dr. Carlos Bedolla Zavala
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Farmacodinamia
Son Agonistas del GABA
Se unen a su propio receptor
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Farmacodinamia
Inhibición del GABA
Agonistas de GABA-BZD
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Efectos producidos por activación del receptor GABA A
Sedación
Amnesia
Miorelajante
Ansiolitico
Anticonvulivante
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Buena Absorción
Farmacocinética
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Buena Absorción
Farmacocinética
La administración de AntiácidosAntidepresivos Ansiolíticos Retardan la absorción
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Buena Absorción
Farmacocinética
perfusión lenta a ritmo inferior a los 10 mg/min.
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Farmacocinética
Absorción errática
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Se unen a proteínas plasmáticas entre 80-100%
Farmacocinética
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Pasan la Barrera hematoencefálicaPlacenta Leche
Farmacocinética
Tiende a acumularse en Tejido graso y cerebral
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Se elimina
Farmacocinética
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T ½ de las benzodiazepinas
Larga
Intermedia
Corta
Ultra corta
ACCIÓN T ½
> 30 hrs
= 30 hrs
10 a 12 hrs
> 5 hrs
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ACCIÓN LARGA: t1/2 MAYOR DE 30 HRS
Comercial Genérico Tab Ampula Efecto
Bromazepam
Clorazepato
Clobazam
Diazepam
Loflazepato
LEXOTAN
TRANXENE
FRISIUM
VALIUM
VICTAN
3, 6
5, 10, 15
10, 20
5, 10
2
10
A
A
A
A
A, AC, RM
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Comercial Genérico Tab Efecto
ACCIÓN INTERMEDIA: t1/2 = 30 HRS
Clonazepam RIVOTRIL
Flunitrazepam ROHYPNOL
0.5, 2
1
A, AC
HY
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Comercial Genérico Tab Efecto
ACCIÓN CORTA: t1/2 DE 10 a 12 HRS
Alprazolam
Lorazepam
Tetrazepam
Pinazepam
TAFIL
ATIVAN
MIOLASTAN
YUNIR
0,25, 0.5, 1, 2
1,2
25, 50
5
A
A
A
RM
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Comercial Genérico Tab Ampula Efecto
ACCIÓN ULTRACORTA: t1/2 MAYOR DE 5 HRS
Midazolam
Triazolam
Brotizolam
DORMICUM
HALCION
LINDORMIN
7.5 5, 15
0.125, 0.250
0.250
HY
HY
HY
Estazolam TASEDAN 2 HY
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Comercial Genérico Tab Efecto
AGONISTAS MODULADORES DE LOS RECEPTORES GABA- FÁRMACOS "Z"
Zopiclone
Zolpiden
Hidroxicina
IMOVANE
NOCTE
ATARAX
Hidrato de cloral
7.5
10, 20
10, 25
HY
HY
A
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Comercial Genérico Ampula Efecto
ANTAGONISTAS DE BZD
Flumazenil LANEXAT 0.5, 1 Antagonista
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EFECTOS SECUNDARIOS
Dependen de la dosis
Somnolencia
Cefalea
Parestesias
Diplopia
Vision borrosa
Ataxia
Nausea y vómito
Agranulocitosis
Neutropenia
Exantemas alérgicos
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SÍNTOMAS DE ABSTINENCIA
Ansiedad
Insomnio
Foto y audio sensibilidad
Hipertension sistolica
Taquicardia
Temblor
Cefalea
Sudoracion
Dolor abdominal
Crisis convulsivas