buenaventura coroleu - corifolitropina en baja reserva - ii simposio reproducción asistida quirón

7/22/2019 Buenaventura Coroleu - Corifolitropina en Baja Reserva - II Simposio Reproduccin Asistida Quirn

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Naghvf (Jgrocgaotrgpohf ) nh pfjonhtns

jgh Bflf Rnsnrvf/Rnspunstf Gvrojf

B. Jgrganu,K. avfrnz, K. Mnvnsf,R. Buxfmnrfs, K. Bgfmf y PH. Bfrro.

Znrvojog mn Knmojohf mn af Rnprgmujjoh.Mnpfrtfknhtg mn Gbstntrojof, Eohnjgagef y Rnprgmujjoh.

Ohstotut ^hovnrsotfro Mnxnus.


2/30

Bflf Rnspunstf nh COS / Ohtrgmujjoh

Ohjomnhjof)

Fsgjofmg) Nhmgkntrogsos(Bfrro y jga. 200>) OKJ nanvfmg (Rfheo y jga,. 2000)

Cfaag gvrojg gjuatg(Hfvgt y jga., 6?45) Bflf Rnsnrvf Gvrojf (Mnvnsf y jga. 2060) Ohnxpaojfmg (Infy y jga., 6??5)

Jgrocgaotrgpohf facf y bflf rnspunstf


3/30

Mncohojoh mn Rnspunstf Gvrojf Pgbrn(Pggr Rnspghsn, tdn Bgagehf jrotnrof)

Fa knhgs 2 mn ags soeuonhtns : fspnjtgs tonhnh qun nstfr prnsnhtns-5 cgajuags g FKD 10.>-6.6 he/ka)

Jghsomnrfjoghns/Fjafrfjoghns< Mgs nposgmogs mn Rnspunstf Gvrojf Pgbrn sgh sucojonhtns pfrf mncohor f

af pfjonhtn jgkg RGP nh fusnhjof mn nmfm kftnrhf fvfhzfmf g prunbfsmn Rnsnrvf Gvrojf fatnrfmfs. Na tnrkohg mn RGP sn rnconrn f rnspunstf, pgr ag qun af prnsnhjof mn uh

jojag mn nstokuafjoh ns nsnhjofa pfrf af mncohojoh. Zoh nkbfreg kulnrnsjgh nmfm fvfhzfmf jgh prunbf mn Rnsnrvf Gvrojf fatnrfmf punmn snrjghsomnrfmfs jgkg pgbrns rnspghmnmgrfs, fuhqun nh so sgh pgsobanspgbrns rnspghmnmgrfs.

Cnrrfrntto FP. nt fa. Duk Rnprgm, 2066Jgrocgaotrgpohf facf y bflf rnspunstf


4/30

BflfRnspunstf

1 = gvgjotgs

HgrkgRnspunstf

DpnrRnspunstf

8 6> gvgjotgs

p

Hknrg 20: >42 54

Nmfm :?.6:.4 :3.?=.0 :>.?=.6 0.006

RCF 3.0=.5 60.0>.4 6>.45.3 0.006

CZD 60.3=.? 4.6:.2 5.02.6 0.006

FKD 0.56.= 6.32.6 2.?2.2 0.006

Fhtfeghostfs EhRD 5?.=% 4=.?% 4:.3% HZ

Gvgjotgs rnjupnrfmgs 2.60.? 4.2:.2 64.?2.4 0.006

Gvgjotgs KOO 6.:6.6 3.>2.4 66.?3.= 0.006

Gvgjotgs Ohsnkohfmgs 6.=6.6 3.4:.0 62.?5.0 0.006

Gvgjotgs Cnjuhmfmgs 0.?0.? =.22.5 4.:>.2 0.006

Nkbroghns trfhscnromgs 0.40.4 6.40.3 6.=0.4 0.006

Jfaomfm Nkbroghnstrfhscnromgs 3.=2.: 5.>0.4 4.66.5 0.006

Nkbroghns jghenafmgs 0.02

0.6 6.2

6.4 :.=

2.? 0.006

Bogkfrjfmgrns mn Rnsnrvf Gvrojf y Rnspunstf Gvrojf


Dgspotfa hovnrsotfrog Vuorh Mnxnus, BfrjnaghfPnrogmg< 2060-2062Pfjonhtns< 43:


5/30

Rnsuatfmgs pgr jojag ohojofmg



6/30

Kfrjfmgrns mn Bflf Rnspunstf Gvrojf



7/30

Erupgs FKD 10.= he/ka RCF 1 5

O (H


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RCF< 15

Zo Hg

=5.=%(6=3/:04)

60.:%(>5/>>>)

FKD10.=

(he/ka)

Zo >=.5%(622/22:)3=.6%

(605/635)23.4%

(6>/>3)

Hg 62,5%(46/3=0)25.5%

(:?/6=6)4.=%

(=2/=??)

O OO

OOO OS

Ohjomnhjof mn Bflf Rnspunstf 1= gvgjotgs rnjupnrfmgs

Jghjgrmfhjof g hg mn ags Bogkfrjfmgrns mn Rnsnrvf Gvrojf



9/30

Rnsuatfmgs pgr jojag ohojofmg

O vs OO9 OO vs OOO< HZO vs OOO< p10.06O, OO y OOO vs OS< p10.006



10/30

Jfkbogs nh afs Ehs

mgsos^sg mn CZD-r / DKE-u

Feghostfs-EhRD

Afreg

Afreg stgp feghostfs

Cafrn-up

Kojrgmgsos

Fhtfeghostfs mn af EhRD

Gtrfs fatnrhftovfs

Prntrftfkonhtg jgh fhtojghjnptovgs

Dgrkghf mn jrnjokonhtg

Fhmrgenhozfjoh ohtrfgvrojf

Jojag hfturfa

Kfmurfjoh Oh-votrg mn gvgjotgs

Fjukuafjoh mn Gvgjotgs (Sotrocojfjoh)

Mghfjoh mn Gvgjotgs

Fatnrhftovfs tnrfputojfs nh af bflf rnspunstf gvrojf



11/30

P. JGR]G F-EHRD SZ. FH]FEGHOZ]FZ / BFLF RNZP^NZ]F

Mnvnsf K.nt fa Eyhnjga Nhmgjrohga, 2060

0

>

60

6>

20

Cafrn-up Fhtfeghost

Jfhjnaaftogh rftn (%) Prnehfhjy rftn/jyjan (%)

Prnehfhjy rftn/ggjytn rntrovfa (%) Prnehfhjy rftn/trfhcnr (%)



12/30

]nstgstnrghf 2:,4%

Ohdobomgrns mn af Frgkftfsf 65.2%

Eghzanz-Jgkfmrfh K. nt fa.RBKGhaohn, 2062

Bgsmgu LInt fa. Duk Rnprgm ^pmftn, 2062

Fhmrgenhozfjoh Gvrojf /]fsf mn Nkbfrfzg



13/30

MDNF 20,?%

Hfriwojdnfh F. nt fa.RB&N, 206:

Fhmrgenhozfjoh Gvrojf /]fsf mn Nkbfrfzg



14/30

Dgrkghf mn Jrnjokonhtg y Bflf Rnspunstf nh COS

Igaobofhfiosnt fa. Duk. Rnprgm. ^pmftn. 6>


15/30

Jfkbogs nh afs Ehs

mgsos^sg mn CZD-r / DKE-u

Feghostfs-EhRD

Afreg

Afreg stgp feghostfs

Cafrn-up

Kojrgmgsos

Fhtfeghostfs mn af EhRD

Gtrfs fatnrhftovfs

Prntrftfkonhtg jgh fhtojghjnptovgs

Dgrkghf mn jrnjokonhtg

Fhmrgenhozfjoh ohtrfgvrojf

Jojag hfturfa

Kfmurfjoh Oh-votrg mn gvgjotgs

Fjukuafjoh mn Gvgjotgs (Sotrocojfjoh)

Mghfjoh mn Gvgjotgs

Fatnrhftovfs tnrfputojfs nh af bflf rnspunstf gvrojf

JGROCGAO]RGPOHF FACF77



16/30

Jgrocgaotrgpohf facf / Bflf Rnspunstf

FutgrIyrgu,

2062

Mosng PR

Jrotnrogs mnOhjausoh 1> gvgjotgs

PrgtgjgagFhte. Fhte.

NaghvfPurnegh

Pfjonhtns 6> 6=

Nmfm =0,6:,: =0,6:,5

Jfhjnafjoh 3,3% -

H Gvgjotgs =,?:,5 :,?2,2

H Nkb/] 6,36,2 6,?6,=

Nkbfrfzgs : 6

/Pfjo. (%) 20 5,6

/Puhj. (%) 26,= 5,6

/]rfhc. (%) 2:,= 60


17/30


FutgrIyrgu,

2062

Pgayzgs,

2062

Mosng PR R

Jrotnrogs mnOhjausoh 1> gvgjotgs Bgagehf Jrotnrof (BJ)

PrgtgjgagFhte. Fhte. Fhte. Feg

NaghvfPurnegh

Naghvf DKEdpPfjonhtns 6> 6= =: 3=

Nmfm =0,6:,: =0,6:,5 :5,?=,2 :?,6=,6

Jfhjnafjoh 3,3% - :2,3% 24,6%

H Gvgjotgs =,?:,5 :,?2,2 :,=6,2 :,:2,:

H Nkb/] 6,36,2 6,?6,= 6,50,4 -

Nkbfrfzgs : 6 : =

/Pfjo. (%) 20 5,6 5 3,:

/Puhj. (%) 26,= 5,6 66,6 ?

/]rfhc. (%) 2:,= 60 6: 62


18/30


FutgrIyrgu,

2062

Pgayzgs,

2062

Pgayzgs,

206:

Mosng PR R R

Jrotnrogs mnOhjausoh 1> gvgjotgs Bgagehf Jrotnrof (BJ) BJ

PrgtgjgagFhte. Fhte. Fhte. Feg Fhte.

NaghvfPurnegh

Naghvf DKEdp Naghvf-DKEdpPfjonhtns 6> 6= =: 3= =5

Nmfm =0,6:,: =0,6:,5 :5,?=,2 :?,6=,6 :5,5:,?

Jfhjnafjoh 3,3% - :2,3% 24,6% 24%

H Gvgjotgs =,?:,5 :,?2,2 :,=6,2 :,:2,: : (0->)

H Nkb/] 6,36,2 6,?6,= 6,50,4 - 6,?0,3

Nkbfrfzgs : 6 : = 4

/Pfjo. (%) 20 5,6 5 3,: 65

/Puhj. (%) 26,= 5,6 66,6 ? 23

/]rfhc. (%) 2:,= 60 6: 62 24



19/30

DKE fctnr jgrocgaaotrgpoh oh yguhe pggr rnspghmnrs

Pgayzgs nt. fa. Duk Rnprgm. mgo< 60.60?:/dukrnp/mnt0=>, 206:Jgrocgaotrgpohf facf y bflf rnspunstf

m b


20/30

Cftnko D.nt fa. Duk Rnprgm. 24< 206:

Rnspunstf Gvrojf y ]fsf mn Nkbfrfzgnh jojags jgh Jgrocgaotrgpohf facf.


]fsf mn nkbfrfzg nvgautovg (F) y tfsf fjukuafmf mn nkbfrfzg (B)


21/30

]fsf mn nkbfrfzg nvgautovg (F) y tfsf fjukuafmf mn nkbfrfzg (B)pgr jojag ohojofmg n ohtnrvfag mn jghcofhzf mna ?>%

(gvgjotgs rnjupnrfmgs y trftfkonhtg)

Cftnko D.nt fa. Duk Rnprgm. 24< 206:Jgrocgaotrgpohf facf y bflf rnspunstf


22/30

Naghvf

6 2 : = > 3 5 4 ? 60 66

Purnegh

Grefautrfh

NaghvfNH PFJONH]NZ JGH BFLF RNZNRSF CGAOJ^AFR

Jgrocgaaotrgpoh facf Purnegh dJE

2 : = > 3 5 4 ?6

efhornaox

Dgspotfa ^hovnrsotfrog Vuorh Mnxnus, 206:Jgrocgaotrgpohf facf y bflf rnspunstf


23/30


Jrotnrogs mn Ohjausoh,>%




25/30

Jojags mnsjfrtfmgs 4/=3 (65.=%)

Naghvf 6>0Purnegh/dKE-DP (^O) 66:>562

Mfs mn nstokuafjoh 60,?2,3

Nstrfmoga mf DJE (pe/ka) ?4?,:=35,2

H mn cgaoj. 862 kk (DJE) =,26,3Puhjoghns :4

H mn Gvgjotgs :,?2,>

H mn Gvgjotgs KOO :,62,0

2 PH 2,:6,2

]rfhscnrnhjofs :3

H mn nkbroghns trfhscnromgs 6,>0,=

H mn nkbfrfzgs 66




26/30

Jojags mnsjfrtfmgs 4/=3 (65.=%)

Naghvf 6>0Purnegh/dKE-DP (^O) 66:>562

Mfs mn nstokuafjoh 60,?2,3

Nstrfmoga mf DJE (pe/ka) ?4?,:=35,2

H mn cgaoj. 862 kk (DJE) =,26,3Puhjoghns :4

H mn Gvgjotgs :,?2,>

H mn Gvgjotgs KOO :,62,0

2 PH 2,:6,2]rfhscnrnhjofs :3

H mn nkbroghns trfhscnromgs 6,>0,=

H mn nkbfrfzgs ?




27/30


Rnsuatfmgs



28/30

CZDr DKE-dp

Jojags 2? 65

Jojags mnsjfrtfmgs >/2? (65.2%) :/65 (65.3%)Naghvf 6>0 6>0

Eghfmgtrgpohfs fmojoghfans (^O) ?>03?? 62:0506

Mfs mn nstokuafjoh 60,?2,3 60,52,=

Nstrfmoga mf DJE (pe/ka) 5??=30 6600=35

H mn cgaoj. 862 kk (DJE) =,=0,? :,?2.6Puhjoghns 2= 6=

H mn Gvgjotgs =,62,6 :,?6,?

H mn Gvgjotgs KOO :,56,? :,>2,6

2 PH 2,46,2 2,26,?

]rfhscnrnhjofs 2: 6:

H mn nkbroghns trfhscnromgs 6,30,: 6,=0,3

H mn nkbfrfzgs 3 :

]fsf mn nkbfrfzg/jojag 20,3% 65,3%




29/30

Na usg mn Naghvf (Jgrocgaotrgpohf-facf)ns oeufa mn ncnjtovg qun af fmkohostrfjohmofrof mn CZD pfrf COS.

]nhonhmg nh junhtf qun sokpaocojf natrftfkonhtg, rnmujjoh mn af jfref mnkuatopans ohynjjoghns mofrofs, y rnsuatfmgs

jghsneuomgs, punmn snr uhf gpjoh fjghtnkpafr nh afs pfjonhtns jgh bflfrnspunstf sgkntomfs f COS.

Jghjausoghns/Rncanxoghns



30/30

Dgspotfa ^hovnrsotfrog Vuorh Mnxnus

Erfjofs

pgrvunstrfftnhjoh!

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buenaventura coroleu - corifolitropina en baja reserva - ii simposio reproducción asistida quirón

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