2da y 3ra semana

8/2/2019 2da y 3ra Semana

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Disco Germinativo BilaminarDr. Abelardo Arias Velsquez


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Clulas germinales

Fecundacin e implantacin

PRIMERA SEMANA DE DESARROLLOEMBRIONARIO


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Formacindelblastocisto

SEGMENTACIN


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ImplantacinEmbrin se implanta en tero

Embrin

endometrio tero

mecanismo


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Anomalas de la Implantacin

Embarazo tubrico

Lugares ms frecuentes


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SEGUNDA SEMANA DE DESARROLLOEMBRIONARIO

Masa celular interna

Epiblasto

Hipoblasto

Dia 8

(embrioblasto)


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membrana amnitica

El epiblastoamnioblastos

saco amnitico

El hipoblastomigracin lateralde clulaspara tapizar la

superficie delblastoceleFormacin demembrana de Heuser


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Trofoblasto

Citotrofoblasto

Sincitiotrofoblasto

Dia 10

Capa de clulas mononucleadas con actividad mittica

Masa multinucleada de expansin rpida


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Disco Germinativo TrilaminarDr. Abelardo Arias Velsquez


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Disco germinativo hacia el final de la segunda semana. El hipoblasto y el

epiblasto se encuentran en contacto entre s y la linea primitiva forma un surco

poco profundo hacia la regin caudal


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GENTICA DEL DESARROLLOHUMANODr. Abelardo Arias Velasquez


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PreguntasBiologia del desarrollo

Como a partir de una clula se llega aun organismo entero?

Cmo sabe un embrin que genes tieneque encender o apagar?

Por qu tenemos la cabeza en lacabeza y la cola en la cola?


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Estructura bsica de una gen

aaa ttt ccc ccg gga ttg ggattt aaa ggg ggg cct aac cct

aaa ttt ccc ccg gga ttg ggattt aaa ggg ggg cct aac cctttt aaa ggg ggg cct aac cctttt aaa ggg ggg cct aac cct

1 2 3 4 5 6

Exn Intrn

RNA

Protena

splicing

Regulacion

P l l


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Procesos moleculares

Premio Nobel de Medicina y Fisiologa 2002. Sydney Brenner, Robert Horvitz y

John Sulston


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Ciclo celular

Proto oncogenSupresor tumoral

Apoptosis

Mitosis

El huevo o la gallina (que fue


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El huevo o la gallina (que fueprimero??)
http://stemcells.nih.gov/info/scireport/chapter1.asp


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Diferenciacincelular
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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Incrementofactor

crecimiento

Incrementoreceptor

factorcrecimiento

Aumento deseales de

transduccin

Incremento en laactividad detranscripcin

Mecanismos de diferenciacin celular
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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Secuencia del control gentico

Genes de efecto materno

- Bicoid- Oskar- Swallow- Caudal- Torso- Trunk

Genes de segmentacin

- Empty- Hunchback- Krupel- Knirps- Orthodenticle- Tailles

Pair rule

Polaridad segmentaria

- Hairy- Runt- Fushi tarazu- Hedhehog- Patchet- Smoothened
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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Comunicacin celular y genes

Molculasreceptoras

Seales detransduccin

Factores deTranscripcin

citoplasma

ncleo

Molculas desenalizacin

GENES DELDESARROLLO

F t d t i i
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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Factores de transcripcin

Clases de factores: Protena Helice-lazo-helice

Protenas en dedo de Zinc Protenas homeodominio

Genes homeoticos Antennapedia

Bithorax

Suelen ser fundamentales en los patrones de expresin gnica

1 2 3 4 5 6Regulacion

Factores de transcripcin:
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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Genes Hox Genes Pax Genes Sox

Factores de transcripcin:homeobox
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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Factores de transcripcin: Hox C-6

Homeobox & Hox Genes

F t d t i i HOX


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http://www.people.virginia.edu/~rjh9u/homeo.html

(Drosophila and Mus)Factores de transcripcin: HOX
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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Protenas homeodominio secuencia


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Protenas homeodominio secuenciahomeobox

Genes Hox: el raton y el ser humano poseen 39 genes homeobox, distribuidos en cuatro cromosomas formandocuatro grupos.

Hoxa (Hox-1)

Hoxb (Hox-2)

Hoxc (Hox-3)

Hoxd (Hox-4)

A1 A2 A3 A4 A5 A6 A7 A9 A10 A11 A13

B1 B2 B3 B4 B5 B6 B7 B8 B9 B13

C4 C5 C6 C8 C9 C10 C11 C12 C13

D1 D3 D4 D8 D9 D10 D11 D12 B13

Direccin de la transcripcion

Direccin de la expresin

Malformaciones del miembro
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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Malformaciones del miembrosuperior

Amelia Hemimelia

AqueiliaAdactilia

Ectrodactilia
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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FOCOMELIA

Cortesia: Dr. Miguel Chavez

Factores de transcripcin: PAX


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Factores de transcripcin: PAXMuchos aspectos del desarrollo, rganos de los sentidos, SN, etc.

Los rganos sensibles a la luz tienen un ancestro comn

opsina

Fotoreceptor

Pigmentos

Ciulas

Pigmentarias

opsina

fotoreceptor

Ojo devertebrado

cornea

lente

Bastones y conos

Nervio

ptico

cornea

lentelente

Ojo deartrpodo

Dif i i l
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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Diferenciacin sexual

Factores de transcripcin: SOX
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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DIFERENCIACION UROGENITAL

Adrenal

Gnada

Rin

Agenesia Gonadal

y renal

Agenesia Gonadaly adrenal

Ovario

Testculo

SRY SOX9

DAX

Factores de transcripcin: SOXSe expresan durante alguna fase del desarrollo, diferenciacion sexual, etc

M l l li d
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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Intervienen en lasinteracciones de los gruposcelulares La familia TGF- B(Factor de

crecimiento transformante Beta)

La familia FGF (Factor de crecimientofibroblstico) La familia Hedgehog

Molculas sealizadoras

Caractersticas Clnicas: Mutacin
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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Caractersticas Clnicas: Mutacinde IGF

(Factor de crecimiento similar a insulina) Macrosomia Macroglosia

Onfalocele Hipoglicemia Visceromegalia Adrenocortical

citomegalia

NefroblastomaBeckwith Wiedeman

D ll d i b

M l l li d
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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Desarrollo de miembrosMolculas sealizadoras

D ll d l i b i


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Desarrollo del miembro superior

PAX

Regulacin molecular en el


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gdesarrollo de miembros

13

14

15

16

17

18

19

20

21

22

23

FGF10

13

14

15

16

17

18

19

20

21

22

23

FGF8

Shh

13

14

15

16

17

18

19

20

21

22

23

FGF8+

FGF4

Shh

Tubo neuralSomites

Mesodermo intermedioMesodermo Lateral

Induccin Respuesta Mantenimiento

activ

acin

A d ti id d d i
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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Areas de actividad mesodrmica

rea decrecimiento

CEA FGF1,2,4

FGF10

Zona de

actividadpolarizante

CEA: Cresta ectodrmica apical
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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Sindactilias

Sindrome de ApertMalformacin


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SHHSonic Hedhegog

Malformacion

S i H d h


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Sonic Hedgehog

CI

Microtubulo

Cos2

Fused

PKASlimb

Reprime expresin gentica

Patched

smoothened

GLI

Molculasreceptoras

Transduccin de la

seal

Expresin gnica

shh

si todas las clulas tiene el mismo material genetico como
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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EPIGENTICA

ges que existen diferentes tejidos? mmmm?

Epigentica


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Epigentica

El proceso de regulacin gentica seproduce por la metilacin o acetilacin del

ADN e histonas respectivamente

3 4 5 6 7 8 9 10 11

Reguladora Regin de trascripcin
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Generacin de clulas pancreticas a partir de clulas troncales

Problema!!!!!!


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Genes

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TIEMPO

Problema!!!!!!
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Cual es el


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blanco?

En resumen los genes del


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En resumen los genes del

desarrollo Dirigen el desarrollo embrionario por

medio de diferentes mecanismos: Factores de transcripcin

Reguladores transcripcionales

Molculas sealizadoras Factores de crecimiento Receptores

Vias de sealizacin
http://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asphttp://stemcells.nih.gov/info/scireport/chapter1.asp


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2da y 3ra semana

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