toronto academic promotional cv report...curriculum vitae maria carmela tartaglia md, frcpc a. date...

Curriculum Vitae

Maria Carmela TartagliaMD, FRCPC

A. Date Curriculum Vitae is Prepared: 2014 December 10

B. Biographical Information

Primary Office Toronto Western HospitalWest Wing 5-449399 Bathurst StToronto, Ontario, CanadaM5T 2S8

Telephone 416-603-5483Fax 416-603-5768Email [email protected]

1. EDUCATION

Degrees

1999 Aug - 2003 Jun M.D.C.M. McGill University, Montreal, Canada

1996 Aug - 1999 Jun BSc, Physiology (minor Neuroscience), McGill University, Montreal, Quebec

1988 Aug - 1992 Jun BA, English (minor Philosophy), McGill University, Montreal, Quebec

Postgraduate, Research and Specialty Training

2008 Jul 1 - 2011 Jun 30 Memory and Aging Center Cognitive Behavioral Fellow, University of California, San Francisco

2003 Jul 1 - 2008 Jun 30 Resident Neurology, Western University, London, Ontario

Qualifications, Certifications and Licenses

2011 Jul - present License, College Physicians of Ontario, Ontario, Canada

2008 Jun - present RCPSC Certification, Royal College of Physicians and Surgeons of Canada, Canada

2009 Jul - 2011 Jun License, Collège des médecins du Québec, Canada

2008 Oct - 2011 May Medical licensure, Medical Board of California, United States

2. EMPLOYMENT

Current Appointments

2011 Jul 1 - present Assistant Professor, Neurology, Medicine, University of Toronto, Toronto, Ontario, Canada

Maria Carmela TARTAGLIA2011 Jul 1 - present Neurologist, Neurology, Toronto Western Hospital, Toronto, Ontario, Canada

Previous Appointments

RESEARCH

1997 Feb - 2003 Jun Research Assistant, McGill UniversityMontreal Neurological Institute, MRS Unit

UNIVERSITY

2009 Jul 1 - 2011 Jun 30 Clinical Lecturer, Neurology, University of California, San Francisco, San Francisco, California, United States

3. HONOURS AND CAREER AWARDS

Distinctions and Research Awards

INTERNATIONAL

Received

2008 Apr Annual Meeting Resident Scholarship, American Academy of Neurology. (Distinction)Apr 12-19, 2008, Chicago, IL.

2007 Oct Travel Award, American Neurological Association. (Distinction)For 132nd Annual Meeting, Oct 7-10, 2007, Washington, DC.

2003 Mar - 2003 Apr Travel Scholarship, American Academy of Neurology. (Distinction)Mar 29-Apr 5, 2003, Honolulu, Hawaii.

PROVINCIAL / REGIONAL

Received

2007 Apr Best Paper Award, Physicians’ Services Incorporated Foundation. (Distinction)Differentiation Between Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis: Examination of Symptoms and Signs at Disease Onset and During Follow-up. Tartaglia MC, Rowe A, Findlater K, Orange JB, Grace GM, Strong MJ.

LOCAL

Received

2010 Mar Outstanding Trainee Poster Award, 20th Annual Rotman Research Institute Conference. (Distinction)“The Frontal Lobes”, Mar 22-26, 2010, Toronto, Canada.

2008 Jun - 2008 Dec McBean Fellowship, University of California, San Francisco. (Research Award)

1999 Jan - 2002 Aug Burroughs Wellcome Fund Student Research Award, Principal investigator, McGill University, Montreal, Quebec. (Research Award)Research award granted for a research project. Three competitions per year. Total Amount: 15,000

of 26Generated by Web CV - 2014 Dec 10

CONFIDENTIAL DOCUMENT

Maria Carmela TARTAGLIA

Student/Trainee Awards

INTERNATIONAL

Received

2014 Jul AAIC 2014 Travel Fellowship, Awardee Name: Anor, C. Alzheimer’s Association International Conference, Copenhagen, DenmarkTotal Amount: 5,000 CAD

NATIONAL

Received

2013 Jul - 2014 Jul 2014 Young Investigator Award in Clinical Research, Neuro-oncology, Awardee Name: Cabrera, S. Canadian Brain Tumour Consortium and 2014 Canadian Neuro-Oncology meeting organizing committee, CanadaTotal Amount: 2,500 CAD

LOCAL

Received

1996 Sep - 2001 Jun Study Grant. Canadian Italian Business and Professional AssociationFinancial award for tuition.

4. PROFESSIONAL AFFILIATIONS AND ACTIVITIES

Professional Associations

2003 - present Junior Member, American Academy of Neurology

2003 - present Member, Canadian Neurological Sciences Federation

2003 - present Member, International Society Magnetic Resonance in Medicine

2012 Jul 1 - 2013 Jun 30 Member, International Society for Frontotemporal Dementia

2011 Jul 1 - 2012 Jun 30 Member, AAN Behavioral Neurology Section

Administrative Activities

INTERNATIONAL

International Society for Frontotemporal Dementia

2012 Sep 4 - present Committee

NATIONAL

Canadian Neurological Sciences Federation

2005 Jun - 2007 Jun President and Resident Representative, Canada.

2004 Jun - 2005 May Resident Vice President, Canada.



Maria Carmela TARTAGLIALOCAL

Alzheimer’s Society of Toronto

2012 Oct 6 - present Board member, Toronto, Ontario, Canada.

University of Toronto

2011 Jul 1 - 2012 Jun 30 Member, Toronto Dementia Research Alliance, Toronto, Ontario, Canada.

2011 Jul 1 - 2012 Jun 30 Brain Medicine Planning Team Member, Toronto, Ontario, Canada.

Western University

2007 Member, Neurology Residents Selection Committee, London, Ontario.

Peer Review Activities

ASSOCIATE OR SECTION EDITING

Senior Contents Editor

2000 - 2003 McGill Journal of Medicine, Number of Reviews: 15

EDITORIAL BOARDS

Editor

2000 McGill Journal of Medicine

GRANT REVIEWS

External Grant Reviewer

2014 Jan 30 - 2014 Jan 31 Alzheimer’s Society Canada Biomedical, Number of Reviews: 11

2013 Jul 1 - 2013 Jul 28 Mitacs, Mitacs Accelerate Program, Number of Reviews: 1

2013 Jan - 2013 Apr Alzheimer’s Association 2013, International Research Grant Program, Number of Reviews: 1

2012 Mar 1 - 2012 Mar 2 Alzheimer’s Society Canada Biomedical, Number of Reviews: 9

2011 Jul 1 - 2012 Jun 30 Alzheimer’s Association 2012, International Research Grant Program, Number of Reviews: 1

MANUSCRIPT REVIEWS

Reviewer

2014 Jan 1 - 2014 Jan 5 Brain Research, Number of Reviews: 1

2013 Oct 1 - 2013 Oct 31 PLOS One, Number of Reviews: 1

2012 Jul 1 - 2013 Jun 30 Cognitive Behavior Neurology, Number of Reviews: 1

2012 Mar - 2014 Feb Can J Neurol Sci, Number of Reviews: 3

2011 Dec BMC Psychiatry, Number of Reviews: 1

2011 Jul 1 - 2013 Aug Movement Disorders, Number of Reviews: 4

2011 Jul 1 - 2012 Jun 30 Acta Neuropathologica, Number of Reviews: 1

2011 Jul - 2013 Aug Neuropsychologia, Number of Reviews: 3

2011 Jul Cerebral Cortex, Number of Reviews: 1

2011 Mini-Reviews in Medicinal Chemistry, Number of Reviews: 1

2011 Psychiatry Research: Neuroimaging, Number of Reviews: 1

2010 - 2013 Jan Human Brain Mapping, Number of Reviews: 3

2010 Alzheimer Disease & Associated Disorders, Number of Reviews: 1

2010 Canadian Journal Neurological Science, Number of Reviews: 1



Maria Carmela TARTAGLIA2010 Neuroimage, Number of Reviews: 1

2010 Neurology, Number of Reviews: 1

2009 - 2011 European Journal of Neurology, Number of Reviews: 2

2008 Apr Brain, Number of Reviews: 1

Book Reviewer

2008 Canadian Journal of Neurological Sciences, Number of Reviews: 1

PRESENTATION REVIEWS

Reviewer

2014 Feb 10 - 2014 Feb 21 Alzheimer’s Imaging Consortium, AAIC 2014, Number of Reviews: 15

C. Research Funding

1. GRANTS, CONTRACTS AND CLINICAL TRIALS

PEER-REVIEWED GRANTS

FUNDED

2014 Sep - 2019 Jul Principal Site Investigator. Frontotemporal Lobar Degeneration Clinical Research Consortium (FTLD CRC). NIH- Rare Diseases Clinical Research Network (RDCRN). PI: Boxer, Adam. 1,250,000 USD. [Grants]

2014 Jul - 2019 Jul Collaborator. Canadian Consortium on Neurodegeneration in Aging (CCNA). CIHR. Canadian Consortium on Neurodegeneration in Aging (CCNA). PI: Hsiung, Robin. 31,000,000 CAD. [Grants]

2014 Jul - 2016 Jul Co-Investigator. The development of a novel biomarker based on epigenetic studies of C9orf72. The W. Garfield Weston Foundation. Rapid Response: Neurodegenerative Diseases of Aging. PI: Rogaeva, Ekaterina. 150,000 CAD. [Grants]

2014 Jul - 2016 Jul Co-Investigator. Tau Ligand for the Diagnosis of Chronic Traumatic Encephalopathy in Retired CFL Athletes. The W. Garfield Weston Foundation. Rapid Response: Neurodegenerative Diseases of Aging. PI: Tartaglia, Carmela. 150,000 CAD. [Grants]

2014 Jul - 2016 Jul Principal Investigator. Assessing the Relationship of White Matter Hyperintensities to Neuropsychiatric Symptoms in Patients with Alzheimer’sDisease. Canadian Institutes of Health Research (CIHR). Catalyst Grant: Secondary Analysis of Neuroimaging Databases. Collaborator(s): L. Collins. 100,000 CAD. [Grants]

2014 Mar - 2019 Mar Co-Investigator. Imaging-genetics biomarkers for disease risk in Alzheimer’s Disease. Canadian Institutes of Health Research (CIHR). PI: Chakravarty, Mallar. 100,000 CAD. [Grants]

2014 Mar - 2019 Mar Principal Investigator. Multimodal Assessment For Predicting Specific Pathological Substrate in Frontotemporal Lobar Degeneration. Canadian Institutes of Health Research (CIHR). Operating Grant. 572,884 CAD. [Grants]

2014 Mar - 2019 Mar Co-Investigator. Genetic Frontotemporal Dementia Initiative (GENFI) in Canada. CIHR. PI:



Maria Carmela TARTAGLIAMasellis, Mario. 932,818 CAD. [Grants]

2014 Mar - 2015 Mar Principal Investigator. Differentiating Frontotemporal Lobar Degeneration Tauopathy from TDP-43 Proteinopathy. University of Toronto Department of Medicine. New Initiatives. 20,000 CAD. [Grants]

2013 Dec - 2018 Dec Co-Investigator. Towards a better understanding of the language impairment and neural basis of primary progressive aphasia: A longitudinal study. Canadian Institutes of Health Research (CIHR). PI: Rochon, Elizabeth. Collaborator(s): S. Black, D. Tang-Wai, N. Graham, M. Freedman, D. Ben-Israel, T. Chow, D. Tang-Wai, Y. Yunusova, C. Léonard. 750,000 CAD. [Grants]

2013 Jul - 2018 Jun SIte Co-Investigator. OBI Integrated Discovery Neurodegeneration Project. Ontario Brain Institute. PI: Strong, Michael. Collaborator(s): UHN: Leanne Casaubon, Tony Lang. 19,000,000 CAD. [Grants]

2013 Mar - 2016 Jul Co-Investigator. Validation of ocular measures as potential biomarkers for early detection of brain amyloid and neurodegeneration. Brain Canada. PI: Black, Sandra. 1,498,490 CAD. [Grants]

2013 Jan - 2016 Jan Co-Investigator. A potential biomarker for vascular dementia. CIHR. Operating Grant. PI: Mikulis, David. 323,764 CAD. [Grants]

2012 Nov - 2014 May Co-Investigator. A methylation study of C9orf72 and the development of a novel diagnostic test. The W. Garfield Weston Foundation. Rapid Response: Neurodegenerative Diseases of Aging. PI: Rogaeva, Ekaterina. 150,000 CAD. [Grants]

2012 Oct - 2013 Oct Co-Investigator. Pilot Project on Imaging of Concussions. Ontario Brain Institute. PI: Charles Tator. Collaborator(s): Toronto Western Hospital/TRI- Charles Tator (Project Leader), Carmela Tartaglia, Robin Green, David Mikulis, and Karen DavisHospital for Sick Children- Jamie Hutchison (Site Leader)McMaster University- Sheila Singh (Site Co-Leader) and Carol DeMatteo (Site Co-Leader)University of Western Ontario- Douglas Fraser (Site Leader) and Ravi Menon. 100,000 CAD. [Grants]

2012 Jul - 2015 Jul Principal Investigator. Assessing Change in Social Cognition and Personality in Neurodegenerative Diseases and Determining Their Neuroanatomical Correlates. Alzheimer Society of Canada. Young Investigator. 149,940 CAD. [Grants]

2012 Mar - 2013 Mar Principal Investigator. Assessing social cognitive impairment in neurodegenerative disease and its impact on caregivers. University of Toronto Department of Medicine. New Initiatives. 30,000 CAD. [Grants]

2012 Mar - 2013 Mar Collaborator. The electronic revised BNA. University of Toronto Department of Medicine. New Initiatives. PI: Tang Wai, David. 30,000 CAD. [Grants]

2011 Jun - 2013 Jun Co-Investigator. The GENetic Frontotemporal Dementia Initiative (GENFI): a new multi-centre platform for the study of frontotemporal lobar degeneration. CIHR. PI: Masellis, Mario. 102,121 CAD. [Grants]

2009 Jul - 2011 Jun Principal Investigator. Evaluation of gray and white matter using structural and diffusion imaging to study early frontotemporal dementia. Fonds de Recherche Sante- Gouvernement du Quebec. FRSQ Fellowship Grant. 108,000 CAD. [Research Fellowships]



Maria Carmela TARTAGLIANON-PEER-REVIEWED GRANTS

FUNDED

2012 Jan - 2014 Jan Site Investigator. 4 Repeat Tauopathy Neuroimaging Initiative. University of California, San Francisco. PI: Boxer, Adam. 94,647 CAD. [Grants]This study is a longitudinal biomarker trial to identify markers of disease progression in 4R tauopathies (Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD). This study will enroll 40 patients with PSP, 40 patients with CBD, and a control group of 120 cognitively normal subjects, each of whom will be seen at timepoints 0, 6, and 12 months. At each visit, each participant will have a clinical evaluation, oculomotor testing, and an MRI scan. Blood and urine biomarkers will be collected annually (at 0 and 12 months) for all participants, and immortalized cell lines will be established from all subjects at baseline. Approximately 80% of subjects will undergo lumbar puncture (LP) at baseline and the final (12mo) visit for analysis of cerebrospinal fluid. The overall objectives of the study are to identify rates of change in biomarkers for 4R tauopathies by repeating measures at multiple timepoints, and to store data for future analyses.

D. Publications

1. PEER-REVIEWED PUBLICATIONS

Journal Articles

1. Forner SA;Takada LT; Bettcher BM;Tartaglia MC; Torres-Chae C, Haman A;Thai J; Vitali P; Neuhaus J; Bostrum A; Miller BL; Rosen HJ; Geschwind M. Comparing CSF biomarkers and brain MRI in the diagnosis of sporadic Jakob-Creutzfeldt disease. Neurology: Clinical Practice. 2014 Sep 23. In Press. Coauthor or Collaborator.

2. Finger E, MacKinley J, Blair M, Oliver L, Jesso S, Tartaglia MC, Borrie M, Wells J, Dzboziak I, Pasternak S, Mitchell D, Rankin K, Kertesz A, Boxer A. Oxytocin for Frontotemporal Dementia: A Randomized Dose-Finding Study of Safety and Tolerability. Neurology. 2014 Sep. In Press. Coauthor or Collaborator.

3. Burke MJ, Fralick M, Nejatbakhsh N, Tartaglia MC, Tator C. In search of evidence-based treatment for concussion: Characteristics of current clinical trials. Brain Injury. 2014 Sep. In Press. Coauthor or Collaborator.

4. Ghani M, Lang AE, Zinman L, Nacmias B, Sorbi S, Bessi V, Tedde A, Tartaglia MC, Surace EI, Sato C, Moreno D, Nalls MA, Singleton A, St George-Hyslop P, Rogaeva E. Mutation analysis of patients with Neurodegenerative disorders using NeuroX array. Neurobiology of Aging. 2014 Aug 1;2014 Aug 1. Coauthor or Collaborator.

5. Xi Z, Rainero I, Bruni A, Maletta RG, Nacmias B, Galimberti D, Surace E, Zheng Y, Moreno D, Sato C, Liang Y, Robertson J, Zinman L, Tartaglia MCT, St. George-Hyslop P, Rogaeva E. Hypermethylation of the CpG-island near the C9orf72 G4C2-repeat expansion in FTLD patients. Human Molecular Genetics. 2014 Jun. In Press. Coauthor or Collaborator.

6. Wagshal D, Sankaranarayanan S, Guss V, Berisha F, Lobach I, Karydas A, Voltarelli L, Scherling C, Heuer H, Tartaglia MC, Miller Z, Coppola G, Ahlijanian M, Soares H, Kramer J, Rabinovici G, Rosen H, Miller B, Meredith J, Boxer A. Divergent CSF tau alterations in two common tauopathies: Alzheimer’s disease and Progressive Supranuclear Palsy. Journal of Neurology, Neurosurgery & Psychiatry. 2014 May. In Press. Coauthor or Collaborator.

7. Rosenbloom‎ M‎, Tartaglia MC, Forner SA‎‎, Wong K‎‎, Kuo A, Johnson D, Colacurcio V, Andrews B, Miller B, DeArmond S, Geschwind M. Metabolic disorders with clinical and radiological features of sporadic Jakob-Creutzfeldt Disease. Neurology: Clinical Practice. 2014 Mar 31. In Press. Coauthor or Collaborator.



Maria Carmela TARTAGLIA8. Tartaglia MC, Hazrati LN, Davis KD, Green R, Wennberg R, Mikulis D, Ezerins L, Keightley ML, Tator CH. A Review

of Chronic traumatic encephalopathy and other neurodegenerative proteinopathies. Frontiers in Human Neuroscience. 2014 Feb;8(30). Principal Author.

9. Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer’s disease. N Engl J Med. 2014 Jan 23;370(4):322-33. Coauthor or Collaborator.

10. Zhang Z; Almeida S; Lu Y;Nishimura A; Peng L; Sun D; Wu B; Karydas A; Tartaglia C; Fong J; Miller B; Farese R; Moore M; Shaw C; Gao FB. Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. Plos One. 2013 Oct 15;8(10):e76055. Coauthor or Collaborator.

11. Lee SE, Tartaglia MC, Yener G, Genç S, Seeley WW, Sanchez-Juan P, Moreno F, Mendez M, Klein E, Rademakers R, Munain A, Combarros O, Kramer JH, Kenet RO, Boxer AL, Geschwind MD, Gorno-Tempini ML, Karydas AM, Rabinovici GD, Coppola G, Geschwind D, Miller BL. Neurodegenerative disease phenotypes in carriers of MAPT p.A152T, a risk factor for frontotemporal dementia spectrum disorders and Alzheimer’s disease. Alzheimer’s Disease and Associated Disorders. 2013 Oct;27(4):302-9. Coauthor or Collaborator.

12. Tartaglia MC, Hu B, Mehta K, Neuhaus J, Yaffe K, Miller BL, Boxer A. Demographic and neuropsychiatric factors associated with off-label medication use in frontotemporal dementia and Alzheimer’s disease. Alzheimer Disease & Associated Disorders. 2013 Jun. In Press. Principal Author.

13. Hazrati Lili-Naz, Tartaglia MC, Diamandis P, Green R, Davis KD , Rogaeva E., Wenneberg R, Ezerins L, Tator CH. Heterogeneity of neurodegenerative diseases in professional football players with a history of repetitive head injuries: not all are chronic traumatic encephalopathy. Frontiers in Human Neuroscience. 2013 May 24;7(222). Coauthor or Collaborator.

14. LaMarre AK, Rascovsky K, Bostrom A, Toofanian P, Wilkins S, Ha S, Perry D, Miller Z, Naasan G, LaForce R, Hagen J, Takada L, Tartaglia MC, Kang G, Galasko D, Salmon D, Farias S, Kaur B, Olichney J, Quitania L, Mendez M, Tsai P, Teng E, Dickerson B, Domoto-Reilly K, McGinnis S, Miller BL, Kramer JH. Inter-rater Reliability of the new criteria for behavioral variant Frontotemporal dementia. Neurology. 2013 May 21;80(21):1973-7. Coauthor or Collaborator.

15. Zhang Y, Tartaglia MC, Schuff N, Chiang G, Ching C, Rosen HJ, Gorno-Tempini ML, Miller BL, Weiner MW. MRI signatures of brain macrostructural atrophy and microstructural degradation in frontotemporal lobar degeneration subtypes. J of Alzheimer’s Dis. 2013 Jan 1;33(2):431-44. Coauthor or Collaborator.

16. Keightley ML, Sinopoli K, Davis KD, Mikulis DJ, Wennberg R, Tartaglia MC, Chen JK, Tator CH. Is there evidence for neurodegenerative change following traumatic brain injury in children and youth? A scoping review. Frontiers in Human Neuroscience. 2013;8(139). Coauthor or Collaborator.

17. Almeida S, Zhang Z, Karydas A, Geschwind MD, Tartaglia MC, Gianni D, Sena-Esteves M, Cenik B, Yu G, Herz J, Miller BL, Farese Jr. RV, Gao F. Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects. Cell Report. 2012 Oct 25;2(4):789-98. Coauthor or Collaborator.

18. Wilson SM, Galantucci S, Tartaglia MC, Gorno-Tempini ML. The neural basis of syntactic deficits in primary progressive aphasia. Brain and Language. 2012 Sep;122(3):190-8.

19. Schott JM; ADNI Investigators. Using CSF biomarkers to replicate genetic associations in Alzheimer’s disease. Neurobiol Aging. 2012 Jul;33(7):1486.e9-15. Epub 2011 Apr 3. Coauthor or Collaborator.

20. Carmichael O, Xie J, Fletcher E, Singh B, DeCarli C; Alzheimer’s Disease Neuroimaging Initiative. Localized hippocampus measures are associated with Alzheimer pathology and cognition independent of total hippocampal volume. Neurobiol Aging. 2012 Jun;33(6):1124.e31-41. Epub 2011 Dec 14. Coauthor or Collaborator.

21. Tartaglia MC, Zhang Y, Racine C, Kramer JH, Laluz V, Neuhaus J, Chao L, Rosen H, Miller B, Weiner M. Executive Dysfunction in Frontotemporal Dementia Is Related to Abnormalities in Frontal White Matter Tracts. Journal of Neurology. 2012 Jun;259(6):1071-80. Principal Author.



Maria Carmela TARTAGLIA22. Tartaglia MC, Johnson DY, Thai JN, Cattaruzza T, Garcia, P, DeArmond SJ, Miller BL, Geschwind MD. Clinical

overlap between Jakob-Creutzfeldt Disease and Dementia with Lewy Bodies. Canadian Journal of Neurological Sciences. 2012 May;39(3):304-10. Principal Author.

23. Shen KK, Fripp J, Mériaudeau F, Chételat G, Salvado O, Bourgeat P; Alzheimer’s Disease Neuroimaging Initiative. Detecting global and local hippocampal shape changes in Alzheimer’s disease using statistical shape models. Neuroimage. 2012 Feb 1;59(3):2155-66. Coauthor or Collaborator.

24. Cho Y, Seong JK, Jeong Y, Shin SY, Alzheimer’s Disease Neuroimaging Initiative. Individual subject classification for Alzheimer’s disease based on incremental learning using a spatial frequency representation of cortical thickness data. Neuroimage. 2012 Feb 1;59(3):2217-30. Coauthor or Collaborator.

25. Eskildsen SF, Coupé P, Fonov V, Manjón JV, Leung KK, Guizard N, Wassef SN, Østergaard LR, Collins DL; Alzheimer’s Disease Neuroimaging Initiative. BEaST: brain extraction based on nonlocal segmentation technique. Neuroimage. 2012 Feb 1;59(3):2362-73. Coauthor or Collaborator.

26. Murphy MJ, Grace GM, Tartaglia MC, Orange JB, Chen X, Rowe A, Findlater K, Kozak RI, Freedman M, Lee TY, Strong MJ. Widespread cerebral haemodynamics disturbances occur early in amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2012 Feb;13(2):202-9. Coauthor or Collaborator.

27. Tartaglia MC. Frontotemporal Dementia in Neuroimaging Clinics: Alzheimer’s Disease and other Dementias. Neuroimaging Clin N Am. 2012 Feb;22(1):83-97. Principal Author.

28. Wilson SM, Galantucci S, Tartaglia MC, Rising K, Patterson DK, Henry ML, Ogar JM, DeLeon J, Miller BL, Gorno-Tempini M. Syntactic processing depends on dorsal language tracts. Neuron. 2011 Oct 20;72(2):397-403. Coauthor or Collaborator.

29. Galantucci S, Tartaglia MC, Wilson SM, Henry M, Growdon M, Filippi M, Agosta F, Kramer JH, Dronkers N, Miller BL, Henry RG, Gorno-Tempini M. White matter damage in primary progressive aphasias: a diffusion tensor tractography study. Brain. 2011 Jun. Epub June 2011. Coauthor or Collaborator.

30. Kerchner GA, Tartaglia MC, Boxer AL. Abhorring The Vacuum: Use Of Alzheimer’s Disease Medications in Frontotemporal Dementia. Expert Rev Neurother. 2011 May;11(5):709-17. Coauthor or Collaborator.

31. Tartaglia MC, Rosen H, Miller BL. Neuroimaging in Neurodegenerative disease. Neurotherapeutics. 2011;8(1):82-92. Principal Author.

32. Tartaglia MC, Thai JN, See T, Kuo A, Harbough R, Raudabaugh B, Cali I, Sattavat M, Sanchez H, DeArmond SJ, Geschwind MD. Mutation at Codon 188 of PRNP associated with atypical Prion Disease. JNEN. 2010 Dec;69(12):1120-1227. Principal Author.

33. Tartaglia MC, Vitali P, Agosta F, Rosen H. Imaging in Dementia. Continuum Dementia. 2010 Jun. Principal Author.

34. Tartaglia MC, Sidhu M, Laluz V, Racine C, Rabinovici GD, Creighton K, Karydas A, Rademakers R, Huang EJ, Miller BL, DeArmond SJ, Seeley WW. Sporadic Corticobasal Syndrome due to FTLD-TDP. Acta Neuropathol. 2009 Oct 30.

35. Trojan DA, Arnold DL, Shapiro S, Bar-Or A, Robinson A, Le Cruguel JP, Narayanan S, Tartaglia MC, Caramanos Z, DaCosta D. Fatigue in Post-Poliomyelitis Syndrome: association with Disease-Related, Behavioral, and Psychosocial Factors. PM&R. 2009 May;1(5):442-9.

36. Tartaglia MC, Laluz V, Rowe A, Findlater K, Lee DH, Kramer JH, Strong MJ. Brain atrophy in primary lateral sclerosis. Neurology. 2009 Apr 7;72(14):1236-41.

37. Steckley J, Tartaglia MC, Reddy H, Huang S, Hammond R, Hyson C. CASE REPORT: Systemic lupus erythematosis and right leg weakness. Canadian Journal Neurological Science. 2009 Jan;36(1):98-101.

38. Tartaglia MC, Pelz D, Burneo J, Jenkins M. Critically Appraised Topic: Cerebral Angiography and Diagnosis of CNS Vasculitis. Can. J. Neurol. Sci. 2009 Jan;36:93-94. Principal Author.

39. Suárez J, Tartaglia MC, Vitali P, Erbetta A, Neuhaus J, Laluz V, Miller BL. Characterizing Radiology Reports in Patients with Frontotemporal Dementia. Neurology. 2009;73(13):1073-74.



Maria Carmela TARTAGLIA40. Murphy MJ, Grace GM, Tartaglia MC, Orange JB, Chen X, Rowe A, Findlater K, Kozak RI, Freedman, Strong MJ, &

Lee T-Y. Cerebral hemodynamic changes accompanying cognitive impairment in primary lateral sclerosis. Amyotroph Lateral Scler. 2008 Dec;9(6):359-68.

41. Tartaglia MC, Kertesz A, Ang LC. Delusion and hallucinations in Frontotemporal dementia-a clinicopathological case report. Cognitive and Behavioral Neurology. 2008 Jun;21(2):107-110.

42. Gofton TE, Macdonald DR, Tartaglia MC, Lee DH, Megyesi JF, Hammond RR. Clinical Pathological Correlation: Ataxia and diplopia in a patient with CLL. Canadian Journal Neurological Science. 2008 May;35(2):243-246.

43. Tartaglia MC, Narayanan S, Arnold DL. Mental Fatigue in MS Alters the Pattern and Increases the Volume of Cerebral Activation Required for a Motor Task. European Journal of Neurology. 2008 Apr;15(4):413-419.

44. Tartaglia MC, Di Legge S, Saposnik G, Jain V, Chan R, Bussière M, Hachinski V, Frank C, Hesser K, Pelz D. Acute Stroke With Hyperdense Middle Cerebral Artery Sign Benefits From IV rtPA. Canadian Journal of Neurological Sciences. 2008 Jan;35(5):583-587.

45. Tartaglia MC, Rowe A, Findlater K, Orange JB, Grace GM, Strong MJ. Differentiation Between Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis: Examination of Symptoms and Signs at Disease Onset and During Follow-up. Archives Neurology. 2007 Feb;64(2):232-36.

46. Wild GE, Drozdowski L, Tartaglia C, Clandinin MT, Thomson ABR. Nutritional modulation of the inflammatory response in inflammatory bowel disease- From the molecular to the integrative to the clinical. World J Gastroenterol. 2007 Jan;13(1):1-7.

47. Trojan DA, Arnold DL, Collet JP, Shapiro S, Bar-Or A, Robinson A, LeCruguel JP, Ducruet T, Narayanan S, Arcelin K, Wong AN, Tartaglia MC, Lapierre Y, Caramanos Z, DaCosta D. Fatigue in Multiple Sclerosis: association with disease-related, behavioral, and psychosocial factors. Multiple Sclerosis. 2007;13(8):985-995.

48. Tartaglia MC, Narayanan S, Francis S, Santos AC, De Stefano N, Arnaoutelis R, Lapierre Y, Arnold DL. The relationship between diffuse axonal damage and fatigue in MS. Archives of Neurology. 2004 Feb;61(2):201-207. Editorial by Michael K. Racke Archives of Neurology, Feb 61(2) 176-177. Part of CME course. Work mentioned in “Groundbreaking work at the Neuro” an article by Joshua Karpati in National Review of Medicine (April 15,2004).

49. De Stefano N, Narayanan S, Francis S, Smith S, Mortilla M, Tartaglia MC, Bartolozzi ML, Guidi L, Federico A, Arnold DL. Diffuse Axonal and Tissue damage is already present in MS patients with low cerebral lesion load and no disability. Archives of Neurology. 2002 Oct;59(10):1565-71.

50. Tartaglia MC, Narayanan S, De Stefano N, Arnaoutelis R, Antel S, Francis S, Santos A, Lapierre Y, Arnold DL. Choline is increased in pre-lesional normal appearing white matter in multiple sclerosis. Journal of Neurology. 2002 Oct;249(10):1382-1390.

51. Santos AC, Narayanan S, De Stefano N, Tartaglia MC, Francis S, Arnaoutelis R, Caramanos Z, Antel S, Pike GB, Arnold DL. Magnetization Transfer can predict clinical evolution in patients with Multiple Sclerosis. Journal of Neurology. 2002 Jun;249(6):662-668.

52. De Stefano N, Narayanan S, Francis GF, Arnaoutelis R, Tartaglia MC, Matthews PM, Antel JP, Arnold DL. Evidence of axonal damage in the early stages of Multiple Sclerosis and its relevance to disability. Archives of Neurology. 2001 Jan;58(1):65-70.

53. Tartaglia MC, Chen JT, Caramanos Z, Taivassalo T, Arnold DL. Muscle phosphorus MRS oxidative indices correlate with physical activity. Muscle & Nerve. 2000;23:175-181.

Abstracts

Anor CJ, Saund A, Tang-Wai D, Keren R, Tartaglia MC. Comparing Neuropsychiatric Symptoms in Patients with Alzheimer’s disease and Vascular Dementia. ADAD. 2013. In Press. Senior Responsible Author.



Maria Carmela TARTAGLIARohrer JD, Frisoni G, Galimberti D, Masellis M, Rowe J, Borroni B, Bruni A, Finger E, Gerhard A, Graff C, Sorbi S, van

Swieten J, Tagliavini F, Benussi L, Binetti G, Black S, Chow T, Colao R, Dopper E, Fenoglio C, Fox N, Freedman M, Fumagalli G, Ghidoni R, Giaccone G, Jones M, Keren R, Nacmias B, Ourselin S, Padovani A, Pievani M, Scarpini E, Tang-Wai D, Tartaglia MC, Warren J, Rossor MN. GENFI – The GENetic Frontotemporal dementia Initiative. Dementia and Geriatric Cognitive Disorders. 2012 Sep;34(Supp 1). Coauthor or Collaborator.

Galantucci S, Tartaglia MC, Wilson SM, Henry M, Jang J, Filippi M, Agosta F, Dronkers NF, Ogar JM, Miller BL, Gorno Tempini ML. White matter microstructural damage in language tracts in primary progressive aphasias: a diffusion-tensor tractography study. Neurology. 2011 Oct;134(Pt 10):3011-29.

Tartaglia MC, Galantucci S, Wilson S, Henry M, Growdon M, Filippi M, Dronkers N, Miller M, Gorno-Tempini ML. Diffusivity abnormalities in specific white matter tracts contribute to impairment in repetition in primary progressive aphasia. Neurology. 2011;76(Suppl 4):A456.

Fine EM, LaMarre AK, Tartaglia MC, Kramer JH, Miller BL, Seeley WW, Boxer AL. The cognitive and behavioral features associated with co-morbid progressive supranuclear palsy and Alzheimer’s disease: More than the sum of its parts? Neurology. 2011;76(Suppl 4).

Hu B, Tartaglia MC, Mehta KM, Miller BL, Boxer AL. Medication Use Differs in Alzheimer’s disease and Frontotemporal dementia. Neurology. 2011;76(Suppl 4).

Wong KS, Forner SA, Tartaglia MC, Haman A, Torres-Chae C, Raudabaugh BJ, Devereux G, Miller BL and Geschwind MD. CSF biomarkers findings in a large rapidly progressive dementia cohort. Neurology. 2011;76(Suppl 4):A77.

Forner SA, Wong KS, Tartaglia MC, Haman A, Torres-Chae C, Raudabaugh BJ, Devereux G, Miller BL and Geschwind MD. Comparison of sensitivity and specificity of CSF biomarkers for sCJD in a rapidly progressive dementia cohort. Neurology. 2011;76(Suppl 4).

Boxer A, Tartaglia MC, Koestler M, Lasky A, Miller Z, Fine E, Karydas A, Miller B. A 12 Week Randomized Placebo Controlled Pilot Clinical Trial of Davunetide for FTLD with Predicted Tau Pathology (CBD, PSP and PNFA). Neurology. 2011;76(Suppl 4).

Tartaglia MC, Luk M, Miller BL, MacKenzie IR. White matter pathology in FTLD-TDP. Dementia and Geriatric Cognitive Disorders. 2010 Sep;30(Suppl 1):85.

Tartaglia MC, Galantucci S, Wilson SM, Henry M, Growdon M, Filippi M, Agosta F, Kramer JH, Dronkers N, Miller BL, Henry RG, Gorno-Tempini M. Tractography Can Be Used For Detecting Abnormalities In Primary Progressive Aphasia. Dementia and Geriatric Cognitive Disorders. 2010 Sep;30(Suppl 1):89.

Tartaglia MC, Galantucci S, Wilson SM, Shany-Ur T, Poorzand P, Growdon M, Jang J, Kramer JH, Miller BL, Gorno-Tempini M, Rankin KP. White Matter Tract Integrity Corresponds With Individual Differences In Emotional Expression And Sensitivity. Dementia and Geriatric Cognitive Disorders. 2010 Sep;30(Suppl 1):84.

Galantucci S, Tartaglia MC, Wilson SM, Henry M, Jung J, Filippi M, Miller BL, Seeley WW, Rankin KP, Kramer JH, Gorno-Tempini M. Connectivity-based segmentation of the anterior temporal lobe: a diffusion tensor imaging study. Dementia and Geriatric Cognitive Disorders. 2010 Sep;30(Suppl 1):86.

Boxer A, Tartaglia MC, Koestler M, Lasky A, Fine E, Heuer H, Mirsky J, Toohey C, Kramer JH, Grossman M, Knopman D, Miller BL. A 12 Week, Randomized, Double-blind, Placebo-Controlled Pilot Clinical Trial of Davunetide 15mg Intranasally Twice Daily for FTLD with Predicted Tau Pathology (CBD, PNFA, PSP). Dementia and Geriatric Cognitive Disorders. 2010 Sep;30(Suppl 1):28.

Karydas A, Coppola G, Tartaglia MC, Lee JJ, Ketelle R, Seeley WW, See T, Kramer JH, Geschwind DH, Miller BL, Rosen H. A Novel Progranulin Mutation in a Family of African Descent with Heterogeneous Clinical Phenotype. Dementia and Geriatric Cognitive Disorders. 2010 Sep;30(Suppl 1):56.

Tartaglia MC, Karydas A, See T, Boxer A, Miller B, Rankin KP. Catechol-O-methyl transferase (COMT) gene polymorphism associated with hallucinations and coldness. Neurology. 2010 Mar 2;74(9):Supp 2.



Maria Carmela TARTAGLIATartaglia MC, Laluz V, Sollberger M, Rademakers R, Karydas A, Baker M, See T, Rankin KP, Miller BL. Polymorphism in

Progranulin gene associated with structural differences in brains of normal controls. Neurology. 2010 Mar 2;74(9):Supp 2.

Tartaglia MC, Zhang Y, Racine C, Kramer JH, Neuhaus J, Chao L, Rosen H, Miller B, Weiner M. Executive Dysfunction in Frontotemporal Dementia Is Related to Abnormalities in Frontal White Matter Tracts. Neurology. 2009;72(11):A437, Supp 3.

Thai JN, Tartaglia MC, Haman A, Johnson DY, DeArmond SJ, Miller BL, Geschwind MD. Clinical Overlap between Jakob-Creutzfeldt Disease and Dementia with Lewy Bodies. Neurology. 2009;72(11):A437, Supp 3.

Trojan DA, Narayanan S, Bar-Or A, Da Costa D, Bernasconi A, Shapiro S, Wong A, Tartaglia MC, Ghassemi R, Le Cruguel J-P, Robinson A, Caramanos A, Lapierre Y, Arnold DL. Magnetic resonance imaging markers of brainstem neuronal injury or inflammation are not significantly associated with multiple sclerosis fatigue. Multiple Sclerosis. 2008;14(Supp 1):S224.

Murphy MJ, Grace GM, Strong MJ, Tartaglia MC, Orange JB, Kozak RI, Chen X, Rowe A, Findlater K, Lee T-Y. Evidence of endothelial dysfunction in Primary Lateral Sclerosis (PLS) with cognitive impairment as measured by CT Perfusion. Journal of Cerebral Blood Flow and Metabolism. 2007 Nov;27(Supp 1s):BP31-05W.

Tartaglia MC, Rowe A, Findlater K, Lee DH, Strong MJ. Gray matter atrophy In primary lateral sclerosis. Journal of Canadian Neurological Science. 2007 May;34(Supp 2):S48.

Murphy MJ, Grace GM, Strong MJ, Tartaglia MC, Orange JB, Kozak RI, Chen X, Rowe A, Findlater K, and Lee T-Y. A comparison of cerebral hemodynamic parameters in patients with ALS and PLS accompanied by changes in cognitive impairment. Amyotrophic Lateral Sclerosis. 2006 Dec;7(3):37-40, Supp 1.

Tartaglia MC, Rowe A, Findlater K, Lee DH, Strong MJ. White Matter Brain Injury As Measured By Magnetization Transfer May Correlate With Disease Duration MND. Amyotrophic Lateral Sclerosis. 2006 Dec;7(3):37-40, Supp 1.

Tartaglia MC, Rowe A, Findlater K, Lee DH, Strong MJ. There Is Evidence For Whole Brain Atrophy In Primary Lateral Sclerosis And It Appears To Be Related To Gray Matter Atrophy As Compared To White Matter Atrophy MND. Amyotrophic Lateral Sclerosis. 2006 Dec;7(3):37-40, Supp 1.

Tartaglia MC, Bihari F, Lee D, Pigott S, Kohler S, Mirsattari S. Using functional MRI to assess memory in patients with temporal lobe epilepsy. Canadian Journal of Neurological Sciences. 2006 May;33(Supp 1).

Murphy MJ, Grace GM, Strong MJ, Tartaglia MC, Orange JB, Kozak RI, Chen X, Rowe A, Findlater K & Lee T-Y. Cerebral Hemodynamic Changes Accompanying Cognitive Impairment In Primary Lateral Sclerosis. Amyotrophic Lateral Sclerosis. 2005 Dec;6(4):127-137, Supp 1.

Tartaglia MC, Rowe A, Findlater K, Strong M. Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis display differences at disease onset and during follow-up that can help differentiate the two illnesses. Amyotrophic Lateral Sclerosis. 2005 Dec;6(4):127-137, Supp 1.

Tartaglia MC, Murphy MJ, Rowe A, Findlater K, Strong M, Orange JB, Grace GM, Kozak RI, Chen X, Lee T-Y. Deficits observed in patients with primary lateral sclerosis are associated with changes in cerebral hemodynamics. Amyotrophic Lateral Sclerosis. 2005 Dec;6(4):127-137, Supp 1.

Tartaglia MC, Arnold DL, Trojan DA. Magnetization Transfer Imaging in Post-poliomyelitis. Canadian Journal of Neurological Sciences. 2004 May;33(Supp 1).

Tartaglia MC, Narayanan S, Arnold DL. Fatigue in MS is Associated with An Altered Pattern and Increased Volume of Cerebral Activation. Supplement to Neurology. 2004;62(7):A294.

Tartaglia MC, Narayanan S, Francis SJ, De Stefano N, Arnaoutelis R, Lapierre Y, Arnold DL. Diffuse Axonal Injury as a Cause of Fatigue in Multiple Sclerosis. Supplement to Neurology. 2003;60(1).

Caramanos Z, Francis SJ, Narayanan S, Tartaglia MC, Santos AC, Pelletier D, Collins DL, Lapierre Y, Arnold DL. The Paradox of Primary Progressive Multiple Sclerosis Unsolved. Supplement to Neurology. 2003;60(1).



Maria Carmela TARTAGLIANarayanan S, Francis SJ, Collins DL, Tartaglia MC, Lapierre Y, Arnold DL. Towards a Multimodal Magnetic Resonance

Surrogate for Disability in Multiple Sclerosis. Supplement to Neurology. 2003;60(1).

De Stefano N, Narayanan S, Francis S, Collins L, Mortilla M, Tartaglia MC, Bartolozzi ML, Guidi L, Federico A, Arnold DL. Axonal damage precedes clinical disability in patients with MS. Neurology. 2001;56(8):A379-A380, Suppl.3.

Tartaglia MC, Narayanan S, De Stefano N, Arnaoutelis R, Antel S, Francis S, Santos A, Lapierre Y, Arnold DL. Choline is increased in pre-lesional normal appearing white matter in Multiple Sclerosis. Neurology. 2001;56(8):A460 Suppl.3.

Narayanan S, De Stefano N, Francis S, Tartaglia MC, Arnaoutelis R, Arnold DL. Disease duration influences relationship between brain axonal injury, spinal cord atrophy and disability in Multiple Sclerosis. Proceedings of the International Society for Magnetic Resonance in Medicine. 2000 Apr;1:297. April 1-7, 2000.

Collins DL, Narayanan S, Caramanos Z, De Stefano N, Tartaglia MC, Arnold DL. Relation of cerebral atrophy in Multiple Sclerosis to severity of disease and axonal injury. Neurology. 2000;54(Supp.3):A17.

Chen JT, Tartaglia MC, Taivassalo T, Kearney RE, Arnold DL. Using nearest-neighbors analysis to evaluate 31P-MRS recovery indices relative to conditioning and metabolic state at rest and end exercise. Proceedings of the International Society for Magnetic Resonance in Medicine. 1999 May;2:1594. May 22-28, 1999.

Book Chapters

Vijverman AC, Tartaglia MC, Fox S. Dementia with Lewy bodies” for the book Movement disorders in dementia. In: Marcello Merello and Sergio Starkstein, editor(s). Movement Disorders in Dementias. Springer; 2013. In Press. Coauthor or Collaborator.

Tartaglia MC. Frontotemporal Dementia. In: Michael J. Aminoff and Robert B. Daroff, editor(s). Encyclopedia of Neurological Sciences. 2nd ed. San Diego (United States): Academic Press, an imprint of ELSEVIER INC; 2012. Coauthor or Collaborator.

Gorno-Tempini ML, Ogar J, Kramer J, Miller B, Rabinovici G, Tartaglia MC. Chapter e10: Primary Progressive Aphasia, Memory Loss, and Other Focal Cerebral Disorders. In: Dan Longo, Anthony Fauci, Dennis Kasper, Stephen Hauser, J. Jameson, Joseph Loscalzo, editor(s). Harrison’s Principles of Internal Medicine. 18th ed. (United States); 2011. Coauthor or Collaborator.

Tartaglia MC, Rosen H. Neuroimaging in Dementia. In: Prof. Bruce L. Miller and Dr. Bradley F. Boeve, editor(s). The Behavioral Neurology of Dementia. Cambridge (United Kingdom): Cambridge University Press; 2009.

Tartaglia MC, Miller BL. Frontal lobe disorders: Frontotemporal Dementia (Pick’s disease). In: The Encyclopedia of Life Sciences (“ELS”). (United States): John Wiley & Sons, Ltd; 2009. Principal Author.

Tartaglia MC, Arnold DL. The role of MRS and fMRI in multiple sclerosis. In: Adv Neurol. 98. 2006. p. 185-202. Principal Author.

Online Publications

The specificity and sensitivity of conventional testing, including the tilt table, for diagnosis of unexplained syncope was not possible to determine. 2006 Feb. Evidence-based Neurology. Available from: http://www.uwo.ca/cns/ebn/cats.html. Principal Author.

2. NON-PEER-REVIEWED PUBLICATIONS

Newspaper Articles

Carmela Tartaglia. Understanding the challenges of early-onset Alzheimer’s can help patients cope. The Globe and Mail. 2014 Sep 19;Health & Fitness. Available from: http://www.theglobeandmail.com/life/health-and-fitness/health-advisor/understanding-the-unique-challenges-of-early-onset-alzheimers-disease-can-help-patients-and-families-cope/article20689951/. Principal Author.



Maria Carmela TARTAGLIACarmela Tartaglia. There’s more to dementia than memory loss. Know the signs. The Globe and Mail. 2014 May

28;Health & Fitness. Available from: http://www.theglobeandmail.com/life/health-and-fitness/health-advisor/theres-more-to-dementia-than-memory-loss-know-the-signs/article18884152/. Principal Author.

Carmela Tartaglia. Decoding Dementia. The Globe and Mail. 2014 Apr 3;Health & Fitness. http://www.theglobeandmail.com/life/health-and-fitness/health-advisor/decoding-dementia-knowing-the-cause-can-help-you-plan-for-the-future/article17794454/#dashboard/follows/. Principal Author.

Online Resources

Conventional cerebral angiography was neither highly specific nor sensitive in the diagnosis of primary CNS vasculitis. University of Western Ontario; 2007 Aug. Evidence-based Neurology. Available from: http://www.uwo.ca/cns/ebn/cats.html. Principal Author.

In suspected cases of leptomeningeal metastases, cerebrospinal fluid (CSF) cytological analysis detected leptomeningeal tumor in less than 60% of cases with only one CSF analysis. The detection rate increased to less than 85% with the second CSF analysis. (Canada): University of Western Ontario; 2007 Apr. Evidence-based Neurology. Available from: http://www.uwo.ca/cns/ebn/cats.html. Principal Author.

There was an association between coffee consumption and the risk of developing Parkinson’s Disease. University of Western Ontario; 2005 May. Evidence-based Neurology. Available from: http://www.uwo.ca/cns/ebn/cats.html. Principal Author.

The McDonald’s MRI criteria may be useful for the early diagnosis of MS in patients presenting with a clinically isolated neurological syndrome. University of Western Ontario; 2004 Nov. Evidence-based Neurology. Available from: http://www.uwo.ca/cns/ebn/cats.html.

A greater number of seizures early on in the disease course entailed higher risk of intractability. University of Western Ontario; 2004 Jun 2. Evidence-based Neurology. Available from: http://www.uwo.ca/cns/ebn/cats.html.

Poem

Tartaglia MC. LOSS poem. From the Other Side of the Fence: Stories from Health Care Professionals. 2008. Principal Author.

3. SUBMITTED PUBLICATIONS

Journal Articles

N. Multani, E. Moro, A. Lang, M. Zurowski, S. Duff Canning, MC Tartaglia. Progression of neuropsychiatric and cognitive features due to exon 2 to 5 deletion in the epsilon-sarcoglycan gene: a case report. American Journal of Medical Genetics. 2014 Dec. Senior Responsible Author.

JD Rohrer, J Nicholas, D Cash, J van Swieten, El Dopper, L Jiskoot, SA Rombouts, MJ Cardoso, S Clegg, M Espak, S Mead, D Thomas, E De Vita, M Masellis, SE Black, M Freedman, R Keren, BJ MacIntosh, E Rogaeva, D Tang-Wai, MC Tartaglia, R Laforce, F Tagliavini, P Tiraboschi16, V Redaelli, S Prioni, M Grisoli, B Borroni, A Padovani, D Galimberti, E Scarpini, A Arighi, G Fumagalli, J Rowe, I Coyle-Gilchrist, C Graff, M Fallström, V Jelic, AK Ståhlbom, C Andersson, H Thonberg, L Lilius, GB Frisoni, M Pievani, M Bocchetta, L Benussi, R Ghidoni, E Finger, S Sorbi, B Nacmias, G Lombardi, C Polito, JD Warren, S Ourselin, NC Fox, MN Rossor. Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia: the Genetic Frontotemporal dementia Initiative (GENFI). JAMA Neurology. 2014 Nov. Coauthor or Collaborator.

Green REA, Terpstra AR, Tartaglia MC, Tator CH, Mikulis D, Davis KD, Wennberg R, Colella B. Psychiatric and Cognitive Characterization of a Sample of Retired Professional Football Players. Sports Medicine. 2014 Oct 1. Coauthor or Collaborator.



Maria Carmela TARTAGLIAS. Cabrera, C. Morel, MC Tartaglia. Cardiofaciocutaneous Syndrome: Report of one case. American Journal of Medical

Genetics. 2014 Oct. Senior Responsible Author.

Goswami R, Dufort P, Tartaglia MC, Green R, Crawley A, Tator C, Wennberg R, Keightley M, Mikulis D, Davis K. Frontotemporal connectivity and structure associations to impulsivity and machine learning predictions in retired professional football players with a history of multiple concussions. Journal of Neuroscience. 2014 Sep. Coauthor or Collaborator.

Anor CJ, O’Connor S, Saund A, Tang-Wai D, Keren R, Tartaglia MC. Neuropsychiatric symptoms in Alzheimer’s disease and vascular dementia. Alzheimer’s and Dementia. 2014 Sep (Trainee publication). Senior Responsible Author.

E. Presentations and Special Lectures

1. INTERNATIONAL

Abstracts and Other Papers

2014 Nov 18 Presenter. Machine learning classifiers discriminate concussed athletes from non-concussed subjects based on diffusion tensor imaging metrics of the uncinate fasciculus. Society for Neuroscience. Washington, District of Columbia, United States. Presenter(s): Dufort P, Goswami R, Tartaglia MC, Green R, Crawley A, Tator CH, Wennberg R, Davis KD. Poster presentation.

2014 Oct Epigenetic study of C9orf72 in FTD and ALS patients including the family with identical twins. 9th International Conference on Frontotemporal Dementias, Oct 25-28. Vancouver, British Columbia, Canada. Presenter(s): Xi Z, Rainero I, Rubino E, Pinessi L, Bruni A, Maletta R, Nacmias B, Sorbi S, Galimberti D, Surace EI, Tartaglia MC, van Blitterswijk M, Rademakers R, Yunusova Y, Robertson J, St. George-Hyslop P, Zinman L, Rogaeva E.

2014 Oct Intranasal Oxytocin for Symptom Treatment in Frontotemporal Dementia: A Randomized, Double-Blind, Placebo Controlled Dose-Finding Study of Safety and Tolerability. 9th International Conference on Frontotemporal Dementias, Oct 25-28. Vancouver, British Columbia, Canada. Presenter(s): Finger E, MacKinley J, Blair M, Jesso S, Oliver L, Pasternak S, Tartaglia MC, Dzobek I, Rankin K, Mitchell D, Kertesz A, Boxer A.

2014 Oct Mutation analysis of C9ORF72 in patients with corticobasal syndrome. 9th International Conference on Frontotemporal Dementias, Oct 25-28. Vancouver, British Columbia, Canada. Presenter(s): Anor CJ, Xi Z, Moreno D, Sato C, Rogaeva E, Tartaglia MC. Author(s): Anor CJ, Moreno D, Sato C, Rogaeva E, Tartaglia MC.

2014 Jul 13 Presenter. Examining the Association between Neuropsychiatric Symptoms, Hypertension, Stroke and the effects of Anti-Hypertensives in Alzheimer’s disease (Poster). Alzheimer’s Association International Conference. Copenhagen, Denmark. Presenter(s): Cassandra J. Anor, Bei Hu, Namita Multani, Maria Carmela Tartaglia. (Trainee Presentation).

2014 Jul 13 Presenter. Relationship between the Uncinate Fasciculus and Personality Traits in Individuals with Alzheimer’s disease (Poster). Alzheimer’s Association International Conference. Copenhagen, Denmark. Presenter(s): Namita Multani, Cassandra J. Anor, David Tang-Wai, Ron Keren, Maria Carmela Tartaglia. (Trainee Presentation).

2014 Jul 13 Presenter. Alteration in superior longitudinal fasciculus integrity correlates aggression index in those with Post Concussive Syndrome. America Academy of Neurology The Sports Concussion Conference. Chicago, Illinois, United States. Presenter(s): Irwin S, Eizenman M, Ebraheem A, Chung J, Multani N, Khobadadi M,Goswami R, Tator C, Green R, Mikulis D, Tartaglia MC. (Trainee Presentation).

2014 Jul 13 Presenter. The race for evidence-based treatment of concussion: characteristics of current clinical trials registered with international databases. American Academy of Neurology Sports Concussion Conference.



Maria Carmela TARTAGLIAChicago, Illinois, United States. Presenter(s): Burke M, Fralick M, Nejatbakhsh N, Tartaglia MC, Tator CH. (Trainee Presentation).

2014 Jul 12 Presenter. Relationship between the Uncinate Fasciculus and Personality Traits in Individuals with Alzheimer’s disease (Poster). Alzheimer’s Imaging Consortium. Copenhagen, Denmark. Presenter(s): Namita Multani, Cassandra J. Anor, David Tang-Wai, Ron Keren, Maria Carmela Tartaglia. (Trainee Presentation).

2014 Jun Presenter. Altered structural organization of the uncinate fasciculus and impulsive behaviour correlates in retired professional athletes with history of concussion. IBIA Tenth World Congress on Brain Injury. San Francisco, California, United States. Presenter(s): Goswami R, Tartaglia MC, Green R, Tator CH, Wennberg R, Hazrati L, Davis KD. (Trainee Presentation).

2014 Apr Mutation analyses of patients with different neurodegenerative diseases by NeuroX array. World Congress on Brain, Behavior and Emotions. Montreal, Quebec, Canada. Presenter(s): Mahdi Ghani, Zhengrui Xi, Anthony E Lang, Lorne Zinman, Maria Carmela Tartaglia, Ezequiel I Surace, Andrew Singleton, Peter St George-Hyslop & Ekaterina Rogaeva. (Trainee Presentation).

2012 Sep GENFI – The GENetic Frontotemporal dementia Initiative. The International Frontotemporal dementia conference. Manchester, Manchester, United Kingdom. Presenter(s): JD Rohrer, G Frisoni, D Galimberti, M Masellis, J Rowe, B Borroni, A Bruni, E Finger, A Gerhard, C Graff S Sorbi, J van Swieten, F Tagliavini, L Benussi, G Binetti, S Black, T Chow, R Colao, E Dopper, C Fenoglio, N Fox, M Freedman, G Fumagalli, R Ghidoni, G Giaccone, M Jones, R Keren, B Nacmias, S Ourselin, A Padovani, M Pievani, E Scarpini, D Tang-Wai, MC Tartaglia, J Warren, MN Rossor.

2012 Apr Co Author. CSF Biomarkers Findings in a Large Rapidly Progressive Dementia Cohort. 64th Annual Meeting of the American Academy of Neurology, New Orleans, Louisiana. New Orleans, Louisiana, United States. Presenter(s): Sven Forner, Katherine Wong, Alan Bostrom, Leonel Takada, Carmela Tartaglia, Aissatou Haman, Charles Torres-Chae, Benjamin Raudabaugh, Gillian Devereux, Bruce Miller, Michael Geschwind.

2012 Apr Neuropsychiatric Features of Parkinsonism Dementia Complex and Other Neurodegenerative Diseases on Guam. 64th Annual Meeting of the American Academy of Neurology. New Orleans, Louisiana. Author(s): Tartaglia MC, Lee SE, Geschwind MD, Perry DC, Afaisen SJ, Khan B, Wu T, Rodriguez H, Ketelle R, Steele J, Miller BL.

2012 Apr Hetereogeneity of Neurodegenerative Diseases on Guam. 64th Annual Meeting of the American Academy of Neurology. New Orleans, Louisiana. Author(s): Lee SE, Tartaglia MC, Geschwind MD, Perry DC, Afaisen SJ, Steele J, Miller BL.

2012 Apr Inter-rater Reliability of the new criteria for behavioral variant Frontotemporal dementia. 64th Annual Meeting of the American Academy of Neurology. New Orleans, Louisiana. Author(s): LaMarre AK, Rascovsky K, Bostrom A, Toofanian P, Wilkins S, Giles KJ, Sha S, Perry D, Tartaglia MC, Kang G, Galasko D, Salmon D, Lehmer M, Farias S, Kaur B, Olichney J, Quitania Park L, Mendez M, Tsai P, Teng E, Miller BL, Kramer J.

2011 Jun 10 White matter correlates of syntactic deficits in primary progressive aphasia (Poster). The 2011 Arizona Alzheimer’s Consortium Scientific Conference. Phoenix, Arizona. Author(s): Wilson SM, Galantucci S, Tartaglia MC, Rising K, Patterson D, Henry ML, Ogar JM, DeLeon J, Miller BM, Gorno-Tempini ML.

2011 May Concordant brain structural and diffusion changes in frontotemporal dementia with and without motor neuron disease (Poster). ISMRM 19th Scientific Meeting & Exhibition, SMRT 20th Annual Meeting. Montreal, Quebec. Author(s): Zhang Y, Schuff N, Tartaglia MC, Laxamana J, Rosen HJ, Gorno-Tempini ML, Miller BL, Weiner ML.

2011 Apr White matter damage in primary progressive aphasias: a diffusion tensor tractography study (Poster). 63nd Annual Meeting of the American Academy of Neurology. Honolulu, Hawaii. Author(s): Galantucci S, Tartaglia MC, Wilson SM, Henry M, Growdon M, Filippi M, Agosta F, Kramer JH, Dronkers N, Miller BL, Henry RG, Gorno-Tempini M.

2011 Apr Medication Use Differs in Alzheimer’s disease and Frontotemporal dementia (Poster). 63nd Annual



Maria Carmela TARTAGLIAMeeting of the American Academy of Neurology. Honolulu, Hawaii. Author(s): Hu B, Tartaglia MC, Mehta KM, Miller BL, Boxer AL.

2011 Apr Comparison of sensitivity and specificity of CSF biomarkers for sCJD in a rapidly progressive dementia cohort (Poster). 63nd Annual Meeting of the American Academy of Neurology. Honolulu, Hawaii. Author(s): Forner SA, Wong KS, Tartaglia MC, Haman A, Torres-Chae C, Raudabaugh BJ, Devereux G, Miller BL and Geschwind MD.

2011 Apr Emotional Expression and Sensitivity Affected by White Matter Tract Integrity (Poster). 63nd Annual Meeting of the American Academy of Neurology. Honolulu, Hawaii. Presenter(s): Tartaglia MC. Author(s): Tartaglia MC, Galantucci S, Wilson SM, Shany-Ur T, Poorzand P, Growdon M, Jang J, Kramer JH, Filippi M, Miller BL, Gorno-Tempini M, Rankin KP.

2011 Neural bases of dyslexia in primary progressive aphasia. Neurobiology of Language Conference. Author(s): Henry M, Galantucci S, Tartaglia MC, Gesierich B, Wilson SM, Babiak M, Miller BL, HenryRG, Gorno-Tempini M.

2010 Oct Connectivity-based segmentation of the anterior temporal lobe: a diffusion tensor imaging study (Poster). Seventh International Conference on Frontotemporal Dementias, Oct 5-8. Indianapolis, Indiana. Author(s): Galantucci S, Tartaglia MC, Wilson SM, Henry M, Jung J, Filippi M, Miller BL, Seeley WW, Rankin KP, Kramer JH, Gorno-Tempini M.

2010 Oct A Novel Progranulin Mutation in a Family of African Descent with Heterogeneous Clinical Phenotype (Poster). Seventh International Conference on Frontotemporal Dementias, Oct 5-8. Indianapolis, Indiana. Author(s): Karydas A, Coppola G, Tartaglia MC, Lee JJ, Ketelle R, Seeley WW, See T, Kramer JH, Geschwind DH, Miller BL, Rosen H.

2010 Oct White matter pathology in FTLD-TDP (Poster). Seventh International Conference on Frontotemporal Dementias, Oct 5-8. Indianapolis, Indiana. Presenter(s): Tartaglia MC. Author(s): Tartaglia MC, Luk M, Miller BL, MacKenzie IR.

2010 Oct Tractography Can Be Used For Detecting Abnormalities In Primary Progressive Aphasia (Poster). Seventh International Conference on Frontotemporal Dementias, Oct 5-8. Indianapolis, Indiana. Presenter(s): Tartaglia MC. Author(s): Tartaglia MC, Galantucci S, Wilson SM, Henry M, Growdon M, Filippi M, Agosta F, Kramer JH, Dronkers N, Miller BL, Henry RG, Gorno-Tempini M.

2010 Oct White Matter Tract Integrity Corresponds With Individual Differences In Emotional Expression And Sensitivity (Poster). Seventh International Conference on Frontotemporal Dementias, Oct 5-8. Indianapolis, Indiana. Presenter(s): Tartaglia MC. Author(s): Tartaglia MC, Galantucci S, Wilson SM, Shany-Ur T, Poorzand P, Growdon M, Jang J, Kramer JH, Miller BL, Gorno-Tempini M, Rankin KP.

2010 Jul Medication Use Differs in Alzheimer’s disease and Frontotemporal dementia (Poster). International Conference Alzheimer’s Disease (ICAD) July 10-15. Honolulu, Hawaii. Presenter(s): Tartaglia MC. Author(s): Tartaglia MC, Mehta KM, Hu B, Miller BL, Boxer AL.

2010 May A Diffusion Tensor Imaging Study of Cross-sectional and Longitudinal White Matter Alterations in Frontotemporal Lobar Degeneration (E-Poster). Joint Annual Meeting ISMRM-ESMRMB 2010 SMRT 19th Annual Meeting, 1-7 May. Stockholm, Sweden. Author(s): Zhang Y, Tartaglia MC, Schuff N, Ching C, Rosen HJ, Miller BL, Weiner MW.

2010 Apr Polymorphism in Progranulin gene associated with structural differences in brains of normal controls (Poster). 62nd Annual Meeting of the American Academy of Neurology. Toronto, Ontario. Presenter(s): Tartaglia MC. Author(s): Tartaglia MC, Laluz V, Sollberger M, Rademakers R, Karydas A, Baker M, See T, Rankin KP, Miller BL.

2010 Mar Diffusion tensor imaging and executive function in frontotemporal dementia (Poster). 20th Annual Rotman Research Institute Conference, “The Frontal Lobes”, Mar 22-26. Toronto, Ontario. Presenter(s): Tartaglia MC. Author(s): Tartaglia MC, Zhang Y, Racine C, Kramer JH, Neuhaus J, Chao L, Rosen H, Miller B, Weiner M.

2010 Mar Executive dysfunction in frontotemporal dementia is related to abnormalities in frontal white matter tracts.



Maria Carmela TARTAGLIAFront. Hum. Neurosci. Conference Abstract: The 20th Annual Rotman Research Institute Conference, The frontal lobes. Author(s): Tartaglia MC, Zhang Y, Racine C, Neuhaus J, Chao L, Kramer J, Rosen H, Miller BL and Weiner M.

2009 Sep Mutation at Codon 188 of prion gene (PRNP) associated with atypical CJD (Poster). Prion 2009, Sept. 23-25. Chalkidiki, Greece. Author(s): Tartaglia MC, Thai JN, Kuo A, See T, Raudabaugh B, Geschwind M.

2009 Apr Clinical Overlap between Jakob-Creutzfeldt Disease and Dementia with Lewy Bodies (Poster). 61th Annual Meeting of the American Academy of Neurology, April 25-May 2. Seattle, Washington. Author(s): Thai J.N., Tartaglia MC, Haman A, Johnson D.Y., DeArmond S.J., Miller B.L., and Geschwind M.D.

2008 Sep MRI Markers of Brainstem Neuronal Injury or Inflammation are not Significantly Associated with Multiple Sclerosis Fatigue (Poster). World Congress on Treatment and Research in Multiple Sclerosis: ACTRIMS + ECTRIMS + LACTRIMS, Sept. 17-20. Montreal, Quebec. Author(s): Trojan DA, Narayanan S, Bar-Or A, DaCosta D, Bernasconi A, Shapiro S, Wong AN, Tartaglia MC, et al.

2007 Dec Cerebral perfusion associated with cognitive function in patients with ALS: A longitudinal study (Poster). 17th International Symposium on ALS/MND. Toronto, Ontario. Author(s): Murphy MJ, Grace GM, Strong MJ, Tartaglia MC, et al.

2007 Oct Gray matter atrophy in Primary Lateral Sclerosis (Poster). American Neurological Association, 132nd Annual Meeting, Oct 7-10. Washington DC. Presenter(s): Tartaglia MC. TRAVEL AWARD for Abstract.

2007 May Evidence of endothelial dysfunction in Primary Lateral Sclerosis (PLS) with cognitive impairment as measured by CT Perfusion (Poster). 23rd International Symposium on Cerebral Blood Flow and Metabolism, May 20-24. Osaka, Japan. Author(s): Murphy MJ, Grace GM, Strong MJ, Tartaglia MC, et al.

2006 Dec Using functional MRI to assess memory in patients with temporal lobe epilepsy (Poster). 1st Annual North American Regional Epilepsy Congress, December 1-5. San Diego, California. Presenter(s): Tartaglia MC.

2006 Nov White Matter Brain Injury As Measured By Magnetization Transfer May Correlate With Disease Duration MND (Poster). 17th International Symposium on ALS/MND, Nov 30-Dec 2. Yokohama, Japan. Presenter(s): Tartaglia MC.

2006 May MRI evidence for a strong relationship between total cerebral white-matter lesion load and clinical disability in patients with multiple sclerosis (Poster). 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine. Seattle, Washington. Author(s): Caramanos Z, Narayanan S, Francis SJ, Matos AL, Tartaglia MC, et al.

2006 Apr Fatigue in Multiple Sclerosis and Post-Poliomyelitis Syndrome: Relationship with Disease-Related, Behavioral, and Psychosocial Factors (Poster). 58th Annual Meeting of the American Academy of Neurology, April 1-8. San Diego, California. Author(s): Trojan DA, Arnold DL, Collet JP, Shapiro S, Bar-Or A, Bernasconi A, Robinson A, Le Cruguel JP, Ducruet T, Narayanan S, Arcelin K, Wong AN, Tartaglia MC, et al.

2005 Dec Cerebral Hemodynamic Changes Accompanying Cognitive Impairment in Primary Lateral Sclerosis (Poster). 16th International Symposium on ALS/MND, Dec. 8-10. Dublin, Ireland. Author(s): Murphy MJ, Grace GM, Strong MJ, Tartaglia MC, et al.

2005 Dec Deficits observed in patients with primary lateral sclerosis are associated with changes in cerebral hemodynamics (Poster). 16th International Symposium on ALS/MND, Dec 8-10. Dublin, Ireland. Presenter(s): Tartaglia MC.

2005 Dec Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis display differences at disease onset and during follow-up that can help differentiate the two illnesses (Poster). 16th International Symposium on ALS/MND, Dec 8-10. Dublin, Ireland. Presenter(s): Tartaglia MC.

2005 Jun In vivo monitoring of neuronal and myelin changes associated with acute lesions in Multiple Sclerosis (Poster). XXVII International Symposium -Neuron-glia Interaction, June 20-22. Montreal, Quebec. Author(s): Chen JT, De Stefano N, Tartaglia MC, Arnold DL.



Maria Carmela TARTAGLIA2004 May MRI evidence for primary degeneration of myelin and axons in patients with multiple sclerosis.

International Society for Magnetic Resonance in Medicine, Twelfth Scientific Meeting. Kyoto, Japan. Author(s): Caramanos Z, Le Nezet P, Matos A, Tartaglia MC, Francis SJ, Narayanan S, Collins DL, Arnold DL.

2004 Apr Fatigue in MS is Associated with An Altered Pattern and Increased Volume of Cerebral Activation (Poster). 56th Annual Meeting of the American Academy of Neurology, April 24-May 1. San Francisco, California. Presenter(s): Tartaglia MC.

2002 Oct The Relationship Between Diffuse Axonal Damage and Fatigue In MS (Poster). National Medical Student Conference on Psychiatry and Neuroscience of Columbia University. Presenter(s): Tartaglia MC.

2001 Apr Quantification métabolique dans la sclérose en plaque par imagerie spectroscopique RMN (Poster). Journées de Neurologie de langue Française, Apr. 18-21. Lyon, France. Author(s): Sappey-Marinier D, Antel S, Tartaglia MC, et al.

2001 Apr MT can predict clinical evolution in patients with MS (Poster). American Society of Neuroradiology Symposium, Apr. 21-27. Boston, Massachusetts. Author(s): Santos A, De Stefano N, Narayanan S, Tartaglia MC, et al.

2000 Apr Disease duration influences relationship between brain axonal injury, spinal cord atrophy and disability in Multiple Sclerosis. International Society for Magnetic Resonance in Medicine, Eighth Scientific Meeting, April 1-7. Denver, Colorado. Author(s): Narayanan S, De Stefano N, Francis S, Tartaglia MC, Arnaoutelis R, Arnold DL.

1999 May Using nearest-neighbors analysis to evaluate 31P-MRS recovery indices relative to conditioning and metabolic state at rest and end exercise. International Society for Magnetic Resonance in Medicine, Seventh Scientific Meeting, May 22-28. Philadelphia, Pennsylvania. Author(s): Chen JT, Tartaglia MC, Taivassalo T, Kearney RE, Arnold DL.

Invited Lectures and Presentations

2014 Jan 15 Invited Speaker. An Uncommon Cause of a Common Problem. Baycrest. Toronto, Ontario, Canada. Presenter(s): International Northern Africa - Canada Behavioural Neurology Rounds. (Continuing Education).

2013 Jul 17 Invited Speaker. Comparing Neuropsychiatric Symptoms in Patients with Alzheimer’s disease and Vascular Dementia. Alzheimer’s Association International Conference. Boston, United States. Presenter(s): Cassandra Anor. (Trainee Presentation).

2011 Apr The cognitive and behavioral features associated with co-morbid progressive supranuclear palsy and Alzheimer’s disease: More than the sum of its parts? (Platform). 63nd Annual Meeting of the American Academy of Neurology. Honolulu, Hawaii. Author(s): Fine EM, LaMarre AK, Tartaglia MC, Kramer JH, Miller BL, Seeley WW, Boxer AL.

2011 Apr CSF biomarkers findings in a large rapidly progressive dementia cohort (Platform). 63nd Annual Meeting of the American Academy of Neurology. Honolulu, Hawaii. Author(s): Wong KS, Forner SA, Tartaglia MC, Haman A, Torres-Chae C, Raudabaugh BJ, Devereux G, Miller BL and Geschwind MD.

2011 Apr A 12 Week Randomized Placebo Controlled Pilot Clinical Trial of Davunetide for FTLD with Predicted Tau Pathology (CBD, PSP and PNFA) (Platform). 63nd Annual Meeting of the American Academy of Neurology. Honolulu, Hawaii. Author(s): Boxer A, Tartaglia MC, Koestler M, Lasky A, Miller Z, Fine E, Karydas A, Miller B.

2011 Apr Diffusivity Abnormalities in Specific White Matter Tracts Contribute to Impairment in Repetition in Primary Progressive Aphasia (Platform). 63nd Annual Meeting of the American Academy of Neurology. Honolulu, Hawaii. Presenter(s): Tartaglia MC. Author(s): Tartaglia MC, Galantucci S, Wilson SM, Henry M, Growdon M, Filippi M, Dronkers N, Miller BL, Henry R, Gorno-Tempini M.

2010 Nov White matter correlates of syntactic deficits in primary progressive aphasia (Platform). Neurobiology of



Maria Carmela TARTAGLIALanguage Conference, Nov. 11-12. San Diego, California. Author(s): Wilson SM, Galantucci S, Tartaglia MC, Gorno-Tempini ML.

2010 Oct A 12 Week, Randomized, Double-blind, Placebo-Controlled Pilot Clinical Trial of Davunetide 15mg Intranasally Twice Daily for FTLD with Predicted Tau Pathology (CBD, PNFA, PSP) (Platform). Seventh International Conference on Frontotemporal Dementias, Oct 5-8. Indianapolis, Indiana. Author(s): Boxer A, Tartaglia MC, Koestler M, Lasky A, Fine E, Heuer H, Mirsky J, Toohey C, Kramer JH, Grossman M, Knopman D, Miller BL.

2010 Apr Catechol-O-methyl transferase (COMT) gene polymorphism associated with hallucinations and coldness (Platform). 62nd Annual Meeting of the American Academy of Neurology. Toronto, Ontario. Presenter(s): Tartaglia MC. Author(s): Tartaglia MC, Karydas A, See T, Boxer A, Miller B, Rankin KP.

2009 Apr Diffusion tensor imaging and executive function in frontotemporal dementia (Platform). 61th Annual Meeting of the American Academy of Neurology, April 25-May 2. Seattle, Washington. Presenter(s): Tartaglia MC. Author(s): Tartaglia MC, Zhang Y, Racine C, Kramer JH, Neuhaus J, Chao L, Rosen H, Miller B, Weiner M.

2006 Nov There Is Evidence For Whole Brain Atrophy In Primary Lateral Sclerosis And It Appears To Be Related To Gray Matter Atrophy As Compared To White Matter Atrophy MND (Platform). 17th International Symposium on ALS/MND, Nov 30-Dec 2. Yokohama, Japan. Presenter(s): Tartaglia MC.

2006 Nov A comparison of cerebral hemodynamic parameters in patients with ALS and PLS accompanied by changes in cognitive impairment (Platform). 17th International Symposium on ALS/MND, Nov 30-Dec 2. Yokohama, Japan. Author(s): Murphy MJ, Grace GM, Strong MJ, Tartaglia MC, et al.

2004 Presenter. N-acetyl aspartate in Multiple Sclerosis and its relationship to Fatigue. McFarland’s Lab Meeting, National Institutes of Health (NIH). Bethesda, Maryland.

2003 Mar Diffuse Axonal Injury as a Cause of Fatigue in Multiple Sclerosis (Platform). 55th Annual Meeting of the American Academy of Neurology, March 29-April 6. Honolulu, Hawaii. Presenter(s): Tartaglia MC.

2001 May Choline is Increased in Pre-lesional Normal Appearing White Matter in Multiple Sclerosis (Platform). 53rd Annual Meeting of the American Academy of Neurology, May 5-11. Philadelphia, Pennsylvania. Presenter(s): Tartaglia MC.

2. NATIONAL


2014 Jun 12 Speaker. Behavioral Syndromes in Patients with Brain Tumors Using the Frontal System Behavior Scale (FrSBe). 2014 Canadian Neuro-Oncology. Halifax, Nova Scotia, Canada. Presenter(s): S. Cabrera, K. Edelstein, W. Mason, MC Tartaglia. (Trainee Presentation).

2010 Mar Executive Dysfunction in Frontotemporal Dementia is Related to Abnormalities in Frontal White Matter Tracts (Poster). 20th Annual Rotman Research Institute Conference – “The Frontal Lobes”, March 22-26. Toronto, Ontario. Presenter(s): Tartaglia MC.

2007 Jun Gray matter atrophy In primary lateral sclerosis (Poster). 42nd Annual Scientific Meeting of Canadian Neurological Sciences Federation, June 19-22. Edmonton, Alberta. Presenter(s): Tartaglia MC.

2007 Jun Longitudinal assessment of cognitive function and concomitant changes in cerebral perfusion in patients with ALS (Poster). 1st Prize Winner. Second International Research Workshop on Frontotemporal Dementia in ALS, June 10-13. London, Ontario. Author(s) Murphy MJ, Grace GM, Strong MJ, Tartaglia MC, et al.

2005 May Mean Transit Time Changes in Primary Lateral Sclerosis Patients with Cognitive Impairment (Poster). First International Research Workshop on Frontotemporal Dementia in ALS, May 15-17. London, Ontario. Author(s): Murphy MJ, Grace GM, Strong MJ, Tartaglia MC, et al.



Maria Carmela TARTAGLIAInvited Lectures and Presentations

2014 Jan 11 Invited Speaker. 2nd Annual Concussion Symposium. UHN Concussion Project. Toronto, Ontario, Canada. (Continuing Education).

2013 Oct 4 Invited Speaker. Primary Progressive Aphasia. The 7th Canadian Conference on Dementia. Vancouver, British Columbia, Canada. (Continuing Education).

2013 Oct 4 Invited Speaker. Tau Therapeutics. The 7th Canadian Conference on Dementia. Vancouver, British Columbia, Canada. Plenary Session. (Continuing Education).

2013 Oct 4 Invited Speaker. Neuropsychiatric Symptoms in Patients with Alzheimer’s disease, Vascular Dementia and Mixed Dementia and Neuroanatomical Correlates. The 7th Canadian Conference on Dementia. Vancouver, British Columbia, Canada. Presenter(s): C. Anor; S. O’Connor, A. Saund, D. Tang-Wai, R. Keren, MC Tartaglia. (Trainee Presentation).

2012 Nov 10 Invited Speaker. Concussions and CTE- Latest Research Developments. Krembil Neuroscince Center-1st Concussion Symposium. Toronto, Ontario, Canada. Presenter(s): C. Tator, M. Keightley, R. Green, K. Davis, D. Mikulis, LN. Hazrati, MC Tartaglia. Present latest research developments on Concussion and CTE-open to lay public and professionnals. Web-diffusion nationally. (Presentation to Patients/Public).

2011 Oct 28 Tau-directed therapeutics. 6th Canadian Conference on Dementia. Montreal, Quebec, Canada. (Continuing Education).

2011 Oct 28 Frontotemporal Dementia. 6th Canadian Conference on Dementia. Montreal, Quebec, Canada. (Continuing Education).

2011 Oct 28 The management of patients with FTD. 6th Canadian Conference on Dementia. Montreal, Quebec, Canada. (Continuing Education).

2007 Dec Fatigue in Multiple Sclerosis is Not Associated with MRI Markers of Brainstem Neuronal Injury or Inflammation (Platform). The Canadian EndMS Research Conference, Dec. 10-13. Banff, Alberta. Author(s): Trojan DA, Narayanan S, Bar-Or A, DaCosta D, Bernasconi A, Shapiro S, Wong AN, Tartaglia MC, et al.

2007 Jun Bibrachial Weakness. (Oral presentation). Neuromuscular Special Interest Group 42nd Annual Scientific Meeting of Canadian Neurological Sciences Federation, June 19-22. Edmonton, Alberta. Presenter(s): Tartaglia MC.

2006 Jun Using functional MRI to assess memory in patients with temporal lobe epilepsy (Platform). 41st Annual Scientific Meeting of Canadian Congress of Neurological Sciences, June 13-17. Montreal, Quebec. Presenter(s): Tartaglia MC.

2004 Jun Magnetization Transfer Imaging in Post-poliomyelitis (Platform). 39th Annual Scientific Meeting of Canadian Congress of Neurological Sciences, June 8-12. Calgary, Alberta. Presenter(s): Tartaglia MC.

2004 Jun The relationship between diffuse axonal damage and fatigue in MS (Platform). 39th Annual Scientific Meeting of Canadian Congress of Neurological Sciences, June 8-12. Calgary, Alberta. Presenter(s): Tartaglia MC.

2003 May Développement de l’imagerie et de la spectroscopie RMN pour le diagnostic et le suivi thérapeutique des maladies cérébrales (Platform). Colloque La recherche sur le vieillissement: accomplissements et enjeux de la prochaine décennie. Sherbrooke, Quebec. Author(s): Sappey-Marinier D, Antel SB, Francis SJ, Tartaglia MC, et al.

Media Appearances

2014 May 15 Invited Speaker. Diagnosis Dementia. Interviewer: Anna Maria Tremonti. The Current, CBC Radio. Ontario, Canada. End date: 2014 May 15. Available from: http://www.cbc.ca/thecurrent/dementia/2014/05/15/canadians-call-in-and-share-their-dementia-stories-1/.



Maria Carmela TARTAGLIA2014 Apr 16 Speaker. Concussion. Interviewer: Line Boily. L’Heure de Pointe, Radio Canada. Toronto, Ontario,

Canada. End date: 2014 Apr 16. Available from: http://ici.radio-canada.ca/emissions/L_heure_de_pointe_Toronto/2013-2014/archives.asp?date=2014-04-16.

2014 Jan 7 Speaker. Dementia. Interviewer: Sandie Rinaldo. CTV global news, CTV. Ontario, Canada. End date: 2014 Jan 7. Available from: http://www.ctvnews.ca/video?clipId=270563.

2014 Jan 6 Speaker. Early onset dementia. Interviewer: Avis Favro. CTV global news, CTV. Canada. End date: 2014 Jan 6. Available from: http://www.ctvnews.ca/health/the-younger-face-of-dementia-ottawa-man-shares-wife-s-battle-with-the-disease-1.1626697.

2013 Aug 13 Interviewee. Concussion. National Post. Canada. End date: 2013 Aug 13.

3. PROVINCIAL / REGIONAL


2014 Jan 23 Invited Speaker. Dementia. Alzheimer’s Society Toronto. Canada.

2013 Sep 17 Invited Speaker. Dementia - need for early diagnosis. Alzheimer’s Society Toronto. Toronto, Ontario, Canada. (Presentation to Patients/Public).

2013 Aug 11 Invited Speaker. Dementia – the times they are a changing. 2013 Summer Symposium of Chinatown Physicians. Toronto, Ontario, Canada. (Continuing Education).

2013 Apr 17 Invited Speaker. Dementia. Alzheimer’s Society Toronto. Toronto, Ontario, Canada. PSW Training Day. (Continuing Education).

2012 Oct 3 Invited Speaker. Dementia - treatment strategies need accurate diagnosis. Alzheimer’s Society Toronto. Toronto, Ontario, Canada. (Presentation to Patients/Public).

2012 May 24 Invited Speaker. Caregiving in Frontotemporal Dementia. Annual National Initiative for the Care of the Elderly (NICE) Knowledge Exchange. Toronto, Ontario, Canada. (Continuing Education).

Media Appearances

2013 Apr 3 Speaker. Dementia. http://www.fairchildtv.com/programarchive_detail.php?n=18&topic=1165&episode=2187#.UZEBexawkxQ.email, fairchildtv. Ontario, Canada. End date: 2013 Apr 3.

4. LOCAL


2013 Aug 16 Speaker. Comparing Neuropsychiatric Symptoms in Patients with Alzheimer’s disease and Vascular Dementia. TWRI Summer Student Research Day. Boston, Canada. Presenter(s): Cassandra J. Anor. (Trainee Presentation).


2014 Nov 8 Invited Speaker. Treatment Update. UHN Memory Clinic. Canada. Caregiver Appreciation/Information Day, University Health Network. (Presentation to Patients/Public).

2014 Nov 8 Speaker. Dementia Update-Caregiver Appreciation/Information Day. Carmela Tartaglia. Toronto, Ontario, Canada. Presenter(s): Carmela Tartaglia.



Maria Carmela TARTAGLIA2014 Oct 28 Invited Speaker. New Investigator. Dept. of Medicine. Ontario, Canada.

2014 Jun 27 Invited Speaker. Frontotemporal Dementia. Neurology Rounds, Division of Neurology, CHU Grenoble, Joseph Fourier University. Grenoble, France.

2014 Jun 26 Invited Speaker. Frontotemporal Dementia. Grand Rounds - Neurologie, Service de Neurologie-Unité Neuro-Vasculaire (UNV), Centre Hospitalier Intercommunal Aix-Pertuis (CHIAP). Aiz-en-Provence, France.

2014 May 9 Invited Speaker. LISTENING for Clues of a LANGUAGE Impairment. Baycrest Psychiatry Rounds. Toronto, Ontario, Canada. (Continuing Education).

2014 Feb 28 Invited Speaker. Brain and behavior. UHN 2014 Alzheimer’s symposium FACING CHALLENGES OF SEVERE DEMENTIA. Toronto, Ontario, Canada. (Continuing Education).

2014 Feb 28 Brain Fitness. TWH Patient Education/Patient and Family Library. (Presentation to Patients/Public).

2014 Jan 15 Speaker. Clinical Pathological Case presentation-Grand rounds. University Health Network. Presenter(s): - copresenters Lee Fidler, Anvita Pauranik, Susy Hota, Maria Carmela Tartaglia. (Continuing Education).

2013 Dec 6 Invited Speaker. Physical Exercise Benefits Cognition: Reality or Myth. 13th Annual Behavioural Neurology Clinic Day Program, University of Toronto. Ontario, Canada. (Continuing Education).

2013 Oct 26 Treatment Update. UHN Memory Clinic. Caregiver Appreciation/Information Day, University Health Network. (Presentation to Patients/Public).

2012 Nov 28 Invited Speaker. A Rapidly Progressive Behavioural Variant FTD. City-wide behavioural neurology. Toronto, Ontario, Canada. (Continuing Education).

2012 Oct 19 Invited Lecturer. 12th Annual Behavioural Neurology Clinic Day Program. Behavioural Neurology Section, Division of Neurology, University of Toronto. Toronto, Ontario, Canada. (Continuing Education).

2012 Sep 15 Speaker. Caregiver Appreciation/Information Day. Maria Carmela Tartaglia. Toronto, Ontario, Canada. Presenter(s): Andrea Iaboni, Pia Kontos, Maria Carmela Tartaglia, Caregivers. (Presentation to Patients/Public).

2012 Sep 15 Speaker. Treatments in Dementia-What’s on the Horizon. UHN Memory Clinic. Toronto, Ontario, Canada. (Presentation to Patients/Public).

2012 Jun 9 Invited Lecturer. Dementia doesn’t say enough. Healthy Living Expo 2012. Toronto, Ontario, Canada. (Presentation to Patients/Public).

2012 Mar 14 Invited Speaker. Dementia. University of Toronto, Faculty of Medicine. Medical Grand Rounds, Faculty of Medicine, Dept of Medicine, Neurology. (Continuing Education).

2012 Feb 29 Invited Speaker. It Isn’t all Gray OR White. Behavioral Neurology Educational Evening. Toronto, Ontario, Canada. Presenter(s): Melanie Cohn. Evening rounds in Behavioral neuology. (Continuing Education).

2012 Jan 27 Invited Speaker. In favor of testing for preclinical Alzheimer’s Disease. Richardson Day, University of Toronto -Neurology. Toronto, Ontario, Canada. (Continuing Education).

2011 Sep 23 Invited Speaker. Frontotemporal Lobar Degeneration - at the center of a paradigm shift in dementia. City Wide Rounds - University of Toronto -Neurology. Toronto, Ontario, Canada. (Continuing Education).

2010 Dec 4 On Hoofbeats, Zebras and Horses - Guam dementia complex. UCSF Grand Rounds. San Francisco, California, United States. Presenter(s): Maria Carmela Tartaglia, Bruce Miller. (Continuing Education).

Media Appearances

2014 Nov 29 Interviewee. Toronto Star Interview. Interviewer: Amy Dempsey. Toronto, Ontario, Canada. Presenter(s): Toronto Star. End date: 2014 Nov 29. Available from: http://www.thestar.com/news/insight/2014/11/28/the_conundrum_of_dementiadriven_wandering.html.



Maria Carmela TARTAGLIA2012 Nov 7 Interviewee. Toronto Star Interview. Toronto, Ontario, Canada. Presenter(s): Toronto Star. End date: 2012

Nov 7.

2012 Oct 11 Interviewee. Global TV News. Toronto, Ontario, Canada.

F. Teaching and Design

1. INNOVATIONS AND DEVELOPMENT IN TEACHING AND EDUCATION

2014 Nov 8 Caregiver Appreciation/Information Day, Patient and Public Education, Faculty of Medicine, Dept of Medicine, NeurologyOrganized this event for Caregiver’s of patients with dementia.

2013 Oct 26 Caregiver Appreciation/Information Day, Patient and Public Education, Faculty of Medicine, Dept of Medicine, NeurologyOrganized this event for Caregiver’s of patients with dementia.

2012 Sep 15 Caregiver Appreciation/Information Day, Patient and Public Education, Faculty of Medicine, Dept of Medicine, NeurologyOrganized this event for Caregiver’s of patients with dementia.

2011 Jul 1 - 2012 Jun 30 Clinical Harmonization, Faculty Development, Faculty of Medicine, Dept of Medicine, Neurology, University of TorontoI was responsible for creating a clinical intake tool that will be used by the 5 academic memory clinics associated with the university of Toronto. This tool will enable a uniform data acquisition when conducting an interview with a patient with cognitive complaints. As well, there will be a standard neurological exam. The standardisation of approach to the patient with cognitive complaints will facilitate research amongst the cognitive behavioral groups at UofT. As well, this tool will help residents rotating in our clinics learn about the different cognitive domains and how to probe for changes in personality, cognition and social cognition.This tool will initially be rolled out to the UofT memory clinics but the plan is to have this used across Ontario and perhaps across Canada so that a nationwide registry of patients with cognitive could be established and queried for epidemiological research on health care necessities, outcomes etc.

2011 Jul 1 - 2012 Jun 30 Neuropsychological Harmonization, Faculty Development, Faculty of Medicine, Dept of Medicine, Neurology, University of TorontoI was involved in a committee to harmonize the neuropsychological assessment of patients presenting with cognitive complaints to the 5 academic memory clinics associated with the university of Toronto. The aim was to create a short battery that could be used by physicians and residents to assess all cognitive domains without having to wait for a full neuropsychological assessment. The tool will enable a uniform data acquisition. The standardisation of the battery will facilitate research amongst the cognitive behavioral groups at UofT. As well, this tool will help residents rotating in our clinics learn how to test the different cognitive domains and we use this information to help make a diagnosis and assess functional impact.

G. Research Supervision

1. PRIMARY OR CO-SUPERVISION

Undergraduate Education

2011 Jul - present Primary Supervisor. B. Sc. Cassandra Anor. Supervisee Institution: University of Toronto at



Maria Carmela TARTAGLIAScarborough. Neuropsychiatric symptoms in dementia and correlation to location of vascular disease.

2013 Jun - 2013 Aug Primary Supervisor. B. Sc. Vrinda Kalra. Supervisee Position: student, Supervisee Institution: University of Toronto. Assessing benefits of exercise in patients with Alzheimer’s Disease. Completed 2015.

2012 Oct - 2013 Mar Primary Supervisor. B. Sc. Meryam Jan. Supervisee Institution: University of Toronto. Assessing benefits of aerobic activity in patients with Alzheimer’s Disease.

Undergraduate MD

2013 Jul - 2014 Jul Primary Supervisor. Year 2. Kevin Kerouac. Supervisee Institution: University of Toronto. Assessing obstacles to physical activity in patients with AD. Completed 2014.

2012 Jul - 2013 Jun Primary Supervisor. Year 2. Robin Chan. Supervisee Institution: University of Toronto. Assessing barriers to physical activity in patients with AD. Completed 2013.

2011 Jul - 2012 Jun Primary Supervisor. Year 2. Giorgia Tropini. Supervisee Position: Medical Student, Supervisee Institution: University of Toronto. The impact of social support and the ability to identify changes in emotion perception in patients on caregiver burden in Alzheimer’s and Parkinson’s disease caregivers : a pilot needs assessment study. Completed 2012.

2011 Jul - 2012 Jun Primary Supervisor. Year 2. Jenna Adleman. Supervisee Position: Medical Student, Supervisee Institution: University of Toronto. An Assessment of How Social Support Relates to Social Cognition and Personality Changes in Patient’s with Alzheimer’s Disease versus Parkinson’s Disease: A pilot needs assessment. Completed 2012.

Postgraduate MD

2013 Oct - 2014 Oct Co-Supervisor. Clinical Fellow. Sergio Cabrera. Collaborator(s): Warren Mason.

2013 Oct - 2014 Oct Primary Supervisor. Clinical Fellow. Ahmed Ebraheem.

2. OTHER SUPERVISION

Graduate Education

Thesis Committee Member

2014 Sep - 2017 Sep PhD. Raphael Schneider. Supervisee Position: PhD student, Supervisee Institution: University of Toronto. MicroRNAs as biomarkers in TDP-43 proteinopathies. Supervisor(s): Janice Robertson.

2013 Jan - 2015 Jun Bhanu Sharma. Collaborator(s): Robin Green, Gary Turner, Deirdre Dawson.

2011 Jul - 2014 Jun MSc. Namita Multani. Supervisee Position: Master’s Student, Supervisee Institution: University of Toronto. Processing of Emotions in Patients with AD. Collaborator(s): Pascal van Lieshout, Boaz Ben David. Completed 2014.

2011 Jul - 2012 Jun PhD. Deborah Schwartz. Supervisee Position: PhD student, Supervisee Institution: University of Toronto. Genetics of Vascular Risk factors. Collaborator(s): Tomas Paus.

Research Assistant

2013 Jul - 2014 Jun Namita Multani. Supervisee Position: Research Assistant.

Undergraduate MD

2009 Jul - 2011 Jun Bei Hu. Supervisee Position: Resident. Medication usage in Ad compared with FTD. Collaborator(s): Adam Boxer. Completed 2011.



Maria Carmela TARTAGLIA

H. Creative Professional Activities

1. CONTRIBUTIONS TO THE DEVELOPMENT OF PROFESSIONAL PRACTICES

2011 Jul - present Harmonized Neuropsychological Assessment.I was involved in a committee to harmonize the neuropsychological assessment of patients presenting with cognitive complaints to the 5 academic memory clinics associated with the university of Toronto. The aim was to create a short battery that could be used by physicians and residents to assess all cognitive domains without having to wait for a full neuropsychological assessment. The tool will enable a uniform data acquisition. The standardisation of the battery will facilitate research amongst the cognitive behavioral groups at UofT. As well, this tool will help residents rotating in our clinics learn how to test the different cognitive domains and we use this information to help make a diagnosis and assess functional impact.There is a necessity for cognitive assessments for making an accurate diagnosis in neurodegenerative disease. This tool is easy to administer and provides domain specific information so as to not only help in the diagnosis of the specific neurodegenerative disease but also provide avenues for compensation. In addition to its clinical utility, it has great potential as a research tool since research questions can be posed of these large datasets.

2011 Jul - 2013 Jun Clinical Harmonization - Standardized Dementia assessment (History and Neurological exam).I was responsible for creating a clinical intake tool that will be used by the 5 academic memory clinics associated with the university of Toronto. This tool will enable a uniform data acquisition when conducting an interview with a patient with cognitive complaints. As well, there will be a standard neurological exam. The standardisation of approach to the patient with cognitive complaints will facilitate research amongst the cognitive behavioral groups at UofT. As well, this tool will help residents rotating in our clinics learn about the different cognitive domains and how to probe for changes in personality, cognition and social cognition.Standardized assessments have been recognized as a necessity for pooling data and being able to ask questions of large datasets.

2. OTHER

2013 Jul 1 - 2014 Jun 30 Helped secure large donation (10M) for the creation of the Slaight Imaging Center.



toronto academic promotional cv report...curriculum vitae maria carmela tartaglia md, frcpc a. date...

Documents