sintesis de novo
DESCRIPTION
Síntesis de novo.TRANSCRIPT
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Mmmmmmm…..Triglicéridos
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GeneralidadesSíntesis de ácidos grasosRegulación
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•Se lleva a cabo a partir de Acetil CoA
•Cito sol
•Reserva energética
•Almacenamiento en adipositos
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•Síntesis de Malonil CoA
•Elongación
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• catalizada por la acetil-CoA carboxilasa
Utiliza:•Acetil CoA•Bicarbonato•ATP•Biotina
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AcetilCoA
Carboxilasa
MalonilCoA
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•Ocurre a través de cuatro reacciones recurrentes
•Llevada a cabo por la ácido graso sintetaza.
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•Llevada a cabo por β-Cetoacil-ACP sintetasa
Acetil CoA+ Malonil ACP = Acetoacetil ACP –Co2
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MalonilCoA
AcetilCoACO2
Aceto-AcetilCoA
Sintetaza
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•
•Llevada a cabo por β-Cetoacil-ACP reductasa
Acetoacetil ACP+ NADPH+H = D-3-Hidroxibutiril ACP
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H
Aceto-AcetilCoA
NADP
D-3Hidroxibutiril
ACP
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•Llevada a cabo por 3-Hidroxiacil-ACP deshidratasa
D-3-Hidroxibutiril ACP = Crotonil-ACP, -H2O
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D-3Hidroxibutiril
ACP
CrotinilACP
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•
•Llevada a cabo por Enoil-ACP reductasa
Crotonil-ACP + NADPH = Butiril ACP + NADP*
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H
NADP
CrotinilACP
ButirilACP
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Agrega Malonil ACP
•Se vuelve a iniciar el ciclo de la elongación
•Siguen agregando 2 carbonos por ciclo
•Hasta formar ácido palmítico de 16 carbonos, el cual se une a una CoA y forma palmitoil CoA
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1. 4 carbonos2. +2 carbonos = 6 carbonos3. +2 carbonos = 8 carbonos4. +2 carbonos = 10 carbonos5. +2 carbonos = 12 carbonos6. +2 carbonos = 14 carbonos7. +2 carbonos = 16 carbonos
• 8 acetil CoA• 7 ATP´S• 14 NADPH
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• Insulina y glucagon
•Palmitonil CoA
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