SISTEMAS DE ADMINISTRACIÓN DE

COLONIASJAX Colony Management System (JCMS) y Anibio

ADMINISTRACIÓN DE COLONIASLOS MODELOS ANIMALES TIENEN UN ROL CRUCIAL EN LA

INVESTIGACIÓN BIOMÉDICA

En cualquier estudio llevado a cabo con animales se necesita:

Trazabilidad

Gestión

Comunicación

EL PROBLEMA DATOS ESCRITOS A MANO O ARCHIVOS EXCEL

• Son sencillos de implementar

• No son aplicables a gran escala

• Tendencia al error

• Difícil acceso simultáneo

• Difícil aplicar filtros de búsqueda

VENTAJASAcceso rápido a los datos

Reducción en errores de transcripción

Base de datos unificada

Inventario preciso de los animales

Control, organización y planificación

JCMS JAX COLONY MANAGEMENT SYSTEM

Gestión de la colonia

Gestión de experimentos

Seguimiento de muestras

Reportes y búsquedas

Datos de animales

Cruzas

Partos y destete

Background genético

Tratamientos

Procedimientos

Cajas y Racks

Filtros de búsqueda

Seguimiento de Pedigree

Actualización de base de datos

JCMS CONFIGURACIONES

Once the software is downloaded, the user is guided

through the setup process. The JCMS User Guide includesa section on ‘‘Getting Started’’ with JCMS that highlights

key aspects of the setup process. The first step in config-

uring the JCMS application is to specify the roles of theindividuals who will be using the software (see the JCMS

Security Model subsection below for descriptions of the

concept of user roles). If used as a stand-alone softwareapplication for a single user, JCMS can be easily installed

without special networking skills or knowledge. If used in

one of the multiclient modes (Fig. 1), the installation mayrequire the assistance of a systems or network adminis-

trator. Once the software is configured and launched, the

user is presented with a function bar that provides access tothe software modules. The main function bar and two of

the JCMS data entry forms, Add Mouse and Edit Mouse,

are shown in Fig. 2.Although all of the JCMS functions are readily acces-

sible from the function bar, a typical JCMS user will use a

subset of the JCMS functions (forms) to support their dailyworkflow and functionality requirements. Figure 3 illus-

trates a typical animal breeding workflow with optional

data entry and report steps. For example, the design-matingform allows users to plan matings and record them in the

database in advance of implementing the actual matings in

the mouse room. It is equally acceptable to skip the designstep and record matings in the database after they are

implemented. Data on litters may be recorded at the time of

birth or when the pups are weaned.JCMS allows users to design and print cage cards with

information derived from the database about the mice

housed in the cage (Fig. 4). Cage numbers printed on eachcard may be bar-coded and allow users to track information

from the cage back to the database. Three classes of cage

cards are defined: (1) mating cards that list litter numbersand pertinent information about the parental mice in the

mating (e.g., genotype, strain, and sex), (2) detail cards that

list information about each individual mouse housed in acage, and (3) wean cards that are designed for groups of

mice housed together from the same litter. JCMS is dis-

tributed with over 20 cage card designs. New designs forcage cards are submitted periodically by the JCMS user

community and distributed with updates to the application.

The JCMS Colony Management Module The centralentity of the JCMS Colony Management module is the

mouse. Every entity in this module (e.g., mating, litter) has

a relationship with the mouse table which facilitatescomplete pedigree tracking over unlimited breeding gen-

erations (from matings to litters to mouse), timed matings

(plug dates), genotype tracking, mouse scheduling, andtracking mouse caging. Leveraging the JCMS extensible

data architecture, design efforts are underway to extend the

data model such that the central entity is ‘‘organism’’ ratherthan mouse. This change in the underlying model for JCMS

Fig. 1 Illustration of the threeprimary installationconfigurations for the JCMSapplication. (1) JCMS can beused as a stand-aloneapplication for a single user, or(2) in a multi-user networkedconfiguration. The most flexibleconfiguration, (3) shows JCMSaccessible via the web andaccessed from multipleoperating system platforms(LINUXTM, WindowsTM orMacintoshTM). In the multi-userconfiguration examples, theblack dots indicate that theremay be any number of users, notjust three users as depicted inthe illustration

C. J. Donnelly et al.: JAX colony management system 209

123

JCMS INTERFAZ

will enable future versions of the application to be used

with other model organisms, including rat and zebrafish.

Animal husbandry workflows are supported by form-driven user interfaces with controlled data entry points. For

example, a mating trio is entered into JCMS by selecting

dams and sires from pulldown menus. Litter strain andbreeding generation terms can be calculated to reduce the

potential for data entry errors.The JCMS Experimental Data Module JCMS includes

an experiment management module that allows users to

link mice to experiments, group tests into experiment plans(i.e., protocols), and associate experimental data with a

specific mouse and test. Experiment plans are composed of

one or more scheduled Experiment tests. For each Exper-iment test there is a user-configurable data descriptor

record that defines the data type (integer, text), names, and

limit constraints of each data element in an Experimental

Data record. When a test is conducted, the data are entered

manually or bulk loaded into JCMS.To load experimental data into the database, users can

use the bulk data-load operations in JCMS that support both

flexible file format specification and preload data-checkingscripts. Preload data checking verifies that data records are

complete, associated with mouse records, and have notalready been loaded and that data values are within appro-

priate ranges. Data files must pass the preload test before

loading into JCMS. A data review report is generated by thesystem before data are loaded into the database. Data loads

are transactional, so either all valid records load correctly,

or the entire transaction is rolled back.Future development of the JCMS application will

include associating input parameters with tests (such as test

Fig. 2 Screen shots of the JCMS welcome page (a), main function bar (b) and forms for adding (c) and editing (d) information about mice.Function buttons are designed to support numerous workflows and are organized by task on the function bar

210 C. J. Donnelly et al.: JAX colony management system

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Haga clic para cambiar el estilo de títuloCLIENTES NORAYBIO

HospitalEs

Universidades

Farmas/CRO

Centros I+D

OtrosUK

2

España23

Portugal Francia21

10

Holanda1 1

Finlandia

1

Noruega

122

23

22

9

10

7

1 10

1 Rumania 1

Paquistan

14

2

3Italia

Australia

1

Brasil3

1Chile

1

Bélgica 2 1

Haga clic para cambiar el estilo de títuloPORTFOLIO

Animal managementsystem

Management of biobanquesand sample collections of

human origin

Analysis of the results of mass spectrometry

experiments over tissuesManagement of

research services

Centros de experimentación

animalBiobancos Laboratorios de

Investigación basicaLaboratorios y centros

de Investigación

Aquatic animalsmanagement system

Management of dailytasks at assisted

reproduction centres

Enzymatic propertiesanalysis software in

metagenomics

Management of laboratories of biological

samples

Centros de Reproducción

Asistida

Management of biobanques and samplecollections of any origin

Software Personalizado

Haga clic para cambiar el estilo de títuloPORTFOLIO

Animal managementsystem

Management of biobanquesand sample collections of

human origin

Analysis of the results of mass spectrometry

experiments over tissuesManagement of

research services

Centros de experimentación

animalBiobancos Laboratorios de

Investigación basicaLaboratorios y centros

de Investigación

Aquatic animalsmanagement system

Management of dailytasks at assisted

reproduction centres

Enzymatic propertiesanalysis software in

metagenomics

Management of laboratories of biological

samples

Centros de Reproducción

Asistida

Management of biobanques and samplecollections of any origin

Software Personalizado

ANIBIOHaga clic para cambiar el estilo de títuloANIBIO BASIC & ADVANCED

AniBio Basic : Software estándar para la gestión de los animalarios

Pedidos animales

Gestión Animales Cruces y

CamadasEtiquetas

PersonalizadasLíneas

TransgenicasNotas y

PlanificaciónJaulas

Comité Ético UsuariosRevisiones e Incidencias

Reports Configuración

AniBio Advanced: incluye más módulos/funcionalidades

Pedidos Animales WEB

Consulta Animales & genotipaje -WEB

Consulta de CrucesWEB Notas

WEBFacturación ServiciosServicios

WEB

Haga clic para cambiar el estilo de títuloANIBIO: MÓDULOS ADICIONALES

La estructura modular de AniBio permite añadir módulos cuando sea necesario:

Gestión Stock

Criopreservación

Reserva de Salas y Equipos

Información Clínica Animal

Revisión de Equipos

…y más.

Pedidos Web

Haga clic para cambiar el estilo de títuloANIBIO: MÓDULOS ADICIONALES

La estructura modular de AniBio permite añadir módulos cuando sea necesario:

Gestión Stock

Criopreservación

Reserva de Salas y Equipos

Información Clínica Animal

Revisión de Equipos

…y más.

Pedidos Web

Expandible:

ANIBIO

TABLA COMPARATIVA

JCMS ANIBIO

Tipo de soporte Mail y foro Directo

Disponibilidad Gratuito Pagado

Idioma Ingles Español

Comunicación No Notas

Expandible No Si

DESVENTAJAS

Difícil implementación

Requieren compra de equipo y/o software

Requieren “marcha blanca”

Requieren entrenamiento