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EFECTO DEL 02 YREOXIGENACIÓN
Jaime Humberto Soto Lugo R2RO
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O!ge" e"#a"$eme"t ratio OER
%ro&or$i'" a(iti)a (e* 02 La &ro&or$i'" (e (o+i+ a(mi"i+tra(a ba,o
$o"(i$io"e+ #i&'i$a+ a aerea(a+ &ara
*ograr mi+mo e-e$to bio*'gi$o 2./1./ &ara r ! r
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3o(i4$a(ore+ (e* OER
5. Fa+e (e* $i$*o 6i")er+o ara(io+e"+ibi*i(a(78
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me"or a 5 G!
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;. Co"$e"tra$i'" 02
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2. E"erg9a (e ra(ia$i'"
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1. Ti&o (e ra(ia$i'"8 De"+i(a(
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3e$a"i+mo (e a$$i'" (e* 02
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3e$a"i+mo (e a$$i'" (e* 02
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Co"$e"tra$i'" <e-e$to
I(ea* 2/? (e02 610mmHg7
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te,i(o+ %rome(io 20
;0 mm Hg
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Co"$e"tra$i'"<e-e$to
6A7 C9r$u*o+ &O2 5.@ mm Hg
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&O2 0.2/ mmHg Cua(ra(o "go8
&O2 0.0@/ mmHg
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Hi&oia
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Hi&oia $r'"i$a
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Hi&oia agu(a )+ $r'"i$a
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Hi&oia ! Hb
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Cur)a+ (e +u&er)i)e"$ia e" tumore+.
CB*u*a+ $o" (i-ere"te+gra(o+ (e Hi&oia
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TB$"i$a+ &ara me(i$i'" (e #i&oia
E&&e"(or- Corre*a$i'" $o" $o"tro*
tumora* ! agre+i)i(a((e tumor
Nitroimi(ao*e+6&imo"i(ao*78 IH
Di+ti"$i'" e"tre te,i(o)iab*e ! "e$r'ti$o
Di+ti"$i'" e"tre #i&oia$r<ag
Co"$e"tra$i'" $e*u*ar
(e 02
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TB$"i$a+ &ara me(i$i'" (e #i&oia8
Nitroimi(ao*e+.
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TB$"i$a+ &ara me(i$i'" (e #i&oia
3ar$a(ore+ e"('ge"o+ (e #i&oia8a"#i(ra+a IX 6CA7 -a$tor i"(u$ib*e &or#i&oia 6HIF7
Regu*a(o+ &or -a$tore+ a(em>+ (e 02 E"+a!o $ometa DNA Com&ara$i'" DS e" te,i(o 'i$o )+
#i&'i$o
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REOXIGENACIÓN
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Reoige"a$i'"
CB*u*a+ #i&'i$a+(e oige"a"&o+terior a u"a
(o+i+ (e ra(ia$i'" Dire$tame"te
&ro&or$io"a* a*tiem&o
Fra$$io"amie"to(e RT
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Se$ue"$i
a e" e*tiem&o
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Se$ue"$ia e" tiem&o (e a$uer(o a ti&o (etumor
Cir$u*o b$o8Car$i"omamamario rat'"
Tri>"gu*o "go8
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3e$a"i+mo+ (ereoige"a$i'"
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Im&orta"$ia (e *a Reoige"a$i'" e" RT
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Im&orta"$ia (e *areoige"a$i'" Fra$$io"amie"to (e (o+i+
Tiem&o (e reoige"a$i'" e+&e$94$o (e$a(a ti&o tumora*
%rome(io 2 a 1 (9a+ CB*u*a+ ue "o re+&o"(e" a Rt
$o")e"$io"a*8 reoige"a$i'" i"a(e$ua(a
La ma!or9a (e *o+ tumore+ "o re+&o"(er9a"a 0 G! e" 10 - +i" 02 Agre+i)i(a( tumora*8 Re+&ue+ta !
%ro"'+ti$o
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Hi&oia ! uimiorre+i+te"$ia
F*u,o +a"gu9"eo Di-u+i'" &H Ra(i$a*e+ *ibre+ %ro*i-era$i'" (i+mi"ui(a
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Hi&oia ! &rogre+i'"5. I"e+tabi*i(a( ge"'mi$a
Ru&tura (e $romo+oma+ ! -u+i'" (e$romo+oma+ (ob*e+ e" regio"e+ -r>gi*e+6HSR7
Am&*i4$a$i'"8 E"(o"u$*ea+a 6&H o&timo ./7 I"#ibi$i'" (e 3*#5: 3+H2: a"( 3+H Aume"to e" i"e+tabi*i(a( &or re&eti$i'" (e
(i"u$*e'ti(o+ Aume"to e" a$ti)i(a( (e Ra( /58
(i+mi"u$i'" (e re$ombi"a$i'" #om'*oga
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Hi&oia ! &rogre+i'"5. I"e+tabi*i(a( ge"'mi$a
Se*e$$i'" (e $B*u*a+ $o" (e-e$to+ e"a&o&to+i+8 b$* 2: &/1
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Hi&oia ! &rogre+i'"5. Fa$tore+ tra"+$ri&$io"a*e+
F a $ t o r
t r a " + $ r i & $ i ' " • H I F 5 a * - a : C R E : A % 0 5 : N F 0 : A T F : X % 0 5
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t r a " + $ r i & $ i o " a *
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Hi&oia ! &rogre+i'"1. Aume"to e" &ote"$ia* meta+t>+i$o
No i"i$ia &ero +i &romue)e e* &ote"$ia*meta+t>+i$o
A$umu*a$i'" (e muta$io"e+8 I"(e&e"(e"$ia a -a$tore+ (e $re$imie"to Degra(a$i'" (e matri etra$e*u*ar %ro(u$$i'" (e -a$tore+ a"giogB"i$o+
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Hi&oia e" tumore+ (e #uma"o+
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La #i&oia e+ u" i"(i$a(or (e agre+i)i(a(tumora* e" &a$ie"te+ $o" CaCu
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La #i&oia e+ u" i"(i$a(or (e agre+i)i(a(tumora* e" &a$ie"te+ $o" CaCu
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&02 me(ia8 @./ mmHg meta+t>+i$o+ )+20 mm Hg "o
met+6& 0.017 Su&er)i)e"$ia *ibre
(e e"-erme(a( a 5Kme+e+8 @0? &02
50 mm Hg )+ 1/?M50 mm Hg 6& 0.057
E+tu(io+ e" #uma"o+
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E+tu(io+ e" #uma"o+.Co"$*u+io"e+ La #i&oia e" u" tumor e+t> re*a$io"a(a
$o" +u agre+i)i(a( ! &or *o ta"to8 Re+&ue+ta a* tratamie"to %rogre+i'" meta+t>+i$a Sobre)i(a g*oba* ! *ibre (e e"-erme(a(