pretes 1 mei · 2021. 6. 10. · kejadian keguguran recurrent miscarriage tiga kali atau lebih...
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PRETES 1 MEI
dr. Syah Rini Wisdayanti Sp.OG,M.Kes
ABORTUS2
Definisi
Umum
• Terminasi kehamilan secara spontan atau diinduksi sebelum fetus viabel/ mampu hidup
Definisi CDC
dan WHO
• Terminasi kehamilan pada usia kehamilan < 20 minggu atau dengan BB fetus < 500 gram
Silver M, Branch DW, Goldenberg R, et al: Nomenclature for pregnancy outcomes. Obstet GynecoI 118 (6) : 1 402, 2011
TERMINOLOGI BARU ABORTUS
American College of Obstetricians and Gynecologists 2017
• kehamilan intrauterin yang nonviable dengan saccus gestasional yang kosong atau saccus gestasional yang mengandung embrio atau janin tanpa aktivitas jantung janin dalam 12 minggu pertama kehamilan.
Istilah klinis
• Abortus spontan: Abortus imminens, insipiens, inkomplit, komplit, dan missed abortion.• Abortus septik: kaitannya dengan infeksi
3
American College of Obstetricians and Gynecologists: Early pregnancy loss. Practice Bulletin No. 150, May 2015 , Reairmed 2017c
INSIDENSI ABORTUS
Pada UK 5-20 minggu mencapai 11-22%
Sering pada UK < 5 minggu
4
Ammon Avalos L, Galindo C, Li OK: A systematic review to calculate background miscarriage rates using life table analysis. Birth Defects Res A Clin Mol TeratoI 94(6) :417, 2012
ABORTUS SPONTAN PADA TRIMESTER PERTAMAPATOFISIOLOGI
Kematian fetus/ embrio diikuti perdarahan ke desidua basal
Nekrosis jaringan yang
merangsang kontraksi uterus
Ekspulsi spontan
5
Silver M, Branch DW, Goldenberg R, et al: Nomenclature for pregnancy outcomes. Obstet GynecoI 118 (6) : 1 402, 2011
FAKTOR FETUS
½ kasus merupakan euploid abortion dan ½ lainnya karena kelainan kromosom
Tingkat aborsi dan anomali kromosom menurun dengan bertambahnya usia kehamilan sering pada UK 8 minggu
Kelainan kromosom terjadi karena 95% kesalahan gametogenesis maternal dan 5% dari ayah.
Kelainan tersering: trisomi (50-60%), monosomiX (9-13%), triploidy
6
Jenderny J : Chromosome aberrations in a large series of spontaneous miscarriages in the German population and review of the literature. Mol Cytogenet 7:38, 2014
FAKTOR MATERNAL7
Wilcox, A., Branch, E., & Weinberg, C. (2018). The role of maternal age and pregnancy history in risk of miscarriage.
Kalagiri RR, Carder T, Choudhuty S, et al: Inlammation in complicated pregnancy and its outcome. Am J Perinatol 33 (14) : 1337, 2016
FAKTOR MATERNAL8
Gaskins AJ, Toth TL, Chavarro JE: Prepregnancy nutrition and early pregnancy outcomes. Curr Nutr Rep 4(3) :265, 2015
Centers for Disease Control and Prevention : Tobacco use and pregnancy. 2016. Available at: https://www.cdc.govlreproductivehealth/maternalinfanthealth/tobaccousepregnancy./ Accessed May 2, 20 16
FAKTOR PATERNAL/ AYAH
Faktor usia ayah (>45 tahun) risiko abortus >>
Kelainan kromosom pada spermatozoa
9
Sartorius GA, Nieschlag E: Paternal age and reproduction. Hum Reprod Update 16 (1) :65, 2010
KLASIFIKASI KLINIS ABORTUS SPONTAN
Abortus Iminens/
Threatened
Abortus Insipien/
Inevitable
Abortus Inkomplit
Abortus komplit
Missed abortion
Septic Abortion
10
Buzad, P., & McCoy, T. W. (2016). Spontaneous abortion and recurrent pregnancy loss. Ob/Gyn secrets E-book, 113.
ABORTUS IMINENS
Bloody discharge dari vagina berhari-
hari/ minggu
Telat menstr
uasi
Kram perut, nyeri
suprapubik,
tekanan di
pelvik, nyeri
punggung
persisten
11
Mouri, M., & Rupp, T. J. (2019). Threatened Abortion. In StatPearls [Internet]. StatPearls Publishing.
ABORTUS IMINENS12
Risiko dari abortus iminen yang tidak mengalami abortus akan meningkatkan risiko dari maternal
maupun perinatal. Risiko tertinggi adalah kelahiran prematur.
EVALUASI DIAGNOTIKPEMERIKSAAN FISIK:• Inspekulo : perdarahan
(+) + oue tertutup
ANAMNESISKehamilan trimester
pertama + perdarahan
pervaginal + nyeri
13
Tujuan: agar dapat mendiagnosis/ menyingkirkan segera kehamilan
ektopik
Mouri, M., & Rupp, T. J. (2019). Threatened Abortion. In StatPearls [Internet]. StatPearls Publishing.
PENUNJANG:• ß-hCG• USG transvaginal
mengetahui lokasi kehamilan dan janin viabel/ tidak
MANAGEMEN ABORTUS IMINENS
Pertahankan
kehamilan
1. Progester
on alamiah2. NSAID
Bed rest
Cek lab: Hb, Ht,
Golongan darah
evaluasi nilai ulang
kondisi janin
14
Mouri, M., & Rupp, T. J. (2019). Threatened Abortion. In StatPearls [Internet]. StatPearls Publishing.
ABORTUS INSIPIEN
Abortus insipien
Terjadi karena spontan, Prosedur
invasive, atau kecelakaan
perdarahan prevaginal,
nyeri
Terdapat Dilatasi Servix
Pada pemeriksaan speculum terdapat genangan cairan
15
Wasson, C., Kelly, A., Ninan, D., & Tran, Q. (2019). Spontaneous abortion. In Absolute Obstetric Anesthesia Review (pp. 89-89). Springer, Cham.
KOMPLIKASI
- Perdarahan sampai dengan syok
- Sepsis
16
TATALAKSANA
Evakuasi hasil
konsepsi
Antibiotik sesuai indikasi
Kuretase
17
ABORTUS INKOMPLIT
Plasenta
lepas sebagi
an
Serviks
dilatasi
Perdarahan
18
Kim C, Barnard 5 , Neilson JP, et al: Medical treatments for incomplete miscarriage. Cochrane Database Syst Rev 1 : CD007223, 20 17
TATALAKSANA
Kuretase
Managemen ekspektatif
Misoprostol/ prostaglandin EI
19
Kim C, Barnard 5 , Neilson JP, et al: Medical treatments for incomplete miscarriage. Cochrane Database Syst Rev 1 : CD007223, 20 17
ABORTUS KOMPLIT
Pengeluaran seluruh hasil konsepsi dari rahim pada kehamilan sebelum 20 minggu dan berat
janin < 500gr.
20
ABORTUS KOMPLITTerdapat riwayat
keluarnya jaringan utuh
(fetus), perdarahan berat, dan
kram
Serviks menutup
Gestasional sac lengkap
yang dikeluarkan
tidak teridentifikasi
USG transvaginal
Hasil abortus komplit:
endometrium menebal
minimal tanpa gestasional
sac
Tidak jelas hasil USG
cek HCG
20
KLASIFIKASI
Pada abortus komplit, terjadi penurunan nilai ß-hCG yang sangat cepat
21
MISSED ABORTIONKematian konsepsi yang telah
dipertahankan selama berhari-hari atau berminggu-minggu di dalam rahim dengan
serviks yang tertutup
USG Transvaginal lebih dipilih dari pada USG Transabdominal
22
TATALAKSANA MISSED ABORTION
Pembedahan Non-Bedah
Misoprostol 800 μg, bisa diulang 1-2 hari
setelahnya
Aspirasi Vakum Manual atau Kuret
25
American College of Obstetricians and Gynecologists: Medical management of first-trimester abortion. Practice Bulletin No. 143, March 20 14, Reairmed 2016c
Tatalaksana Khusus Missed Abortion
◦ Lakukan konseling.
◦ Jika usia kehamilan <12 minggu:◦ evakuasi dengan sendok kuret.
◦ Rekomendasi FIGO: Misoprostol 800μg pervaginam setiap 3 jam (maksimal x2) atau 600μg sublingual setiap 3 jam (maksimal 2x)
◦ Jika usia kehamilan ≥12 minggu namun <16 minggu:◦ pastikan serviks terbuka, bila perlu lakukan pematangan serviks sebelum dilakukan
dilatasi dan kuretase. Lakukan evakuasi dengan tang abortus dan sendok kuret.
◦ Jika usia kehamilan 16-20 minggu:◦ lakukan pematangan serviks.
◦ Lakukan evakuasi dengan infus oksitosin 20 unit dalam 500 ml NaCl 0,9%/Ringer laktat dengan kecepatan 40 tetes/menit hingga terjadi ekspulsi hasil konsepsi.
◦ Bila dalam 24 jam evakuasi tidak terjadi, evaluasi kembali sebelum merencanakan evakuasi lebih lanjut.
SEPTIC ABORTIONAbortus
yang disebabka
n oleh infeksi
Bakteri flora normal vagina adalah
penyebab paling banyakMenyeran
g Miometriu
mParametriti
s(Infeksi pelvic)
Peritonitis
Septicemia
26
DaifJL, Levie M, Chudnof S, e t al: Group A streptococcus causing necrotizing fasciitis and toxic shock syndrome after medical termination of pregnancy.Obstet Gynecol 113 (2 Pt 2): 504, 2009
TANDA DAN GEJALA SEPTIC ABORTION
DemamHypotension
Severe endothelial
injury
Capillary leakage
Hemoconcentration
Leukocytosis
27
TATALAKSANA SEPTIC ABORTION
Ada sisa hasil konsepsi
Peritonitis
Pemberian Antibiotik spektrum luas
Kuretase Laparotomi
Necrotizing Uterus
Histerektomi
Perbaiki KU
28
28
Udoh, A., Effa, E. E., Oduwole, O., Okusanya, B. O., & Okafo, O. (2016). Antibiotics for treating septic abortion. Cochrane Database of Systematic Reviews, (7).
KEGUGURAN BERULANG / RECURRENT MISCARRIAGEKejadian keguguran
tiga kali atau lebih secara berturut-turut dgn UK <20 mg atau
BJ <500 g
Terjadi pada 1% pasangan
subur
34
American Society for Reproductive Medicine: Definitions of infertility and recurrent pregnancy loss. Fertil Steril 99:63, 2013
Faktor Risiko
Hubungan
dengan
risiko
Meningkatnya usia dan paritas
1.3–1.5
Preeklampsia
2.1–4.0
Hipertensi kronik
1.8–3.0
Ketuban pecah dini
2.4–4.9
Kehamilan ganda
2.1
Hidroamnion
2.0
Wanita perokok
1.4–1.9
Trombofilia
3–7
Penggunaan kokain
NA
Riwayat solusio plasenta
10–25
Mioma dibelakang plasenta
8 dari 14
Trauma abdomen dalam kehamilan
Jarang
Prediksi Keberhasilan Kehamilan
Hebatnya, peluang keberhasilan kehamilan mencapai >50% bahkan
setelah lima kali keguguran
35
ETIOLOGI RPL
kelainan kromosom, sindrom
antiphospolipid, dan abnormalitas anatomi
uterus
Kapan terjadinya RPL dapat menjadi petunjuk penting
Faktor genetik → pada kehilangan embryo awal
Kelainan anatomi uterus dan autoimun →
pada TII
40-50% wanita dengan idiopatik RPL
36
El Hachem, H., Crepaux, V., May-Panloup, P., Descamps, P., Legendre, G., & Bouet, P. E. (2017). Recurrent pregnancy loss: current perspectives. International journal of women's health, 9, 331.
ABNORMALITAS KROMOSOM PARENTAL
Hanya 2-4% dari kasus RPL, namun esensial
Kelainan translokasi resiprokal (paling umum) dan translokasi robertsonian
Tx : fertilisasi in vitro diikuti diagnosis genetik preimplantasi
37
El Hachem, H., Crepaux, V., May-Panloup, P., Descamps, P., Legendre, G., & Bouet, P. E. (2017). Recurrent pregnancy loss: current perspectives. International journal of women's health, 9, 331.
FAKTOR ANATOMI
15% wanita RPL memiliki anomali rahim bawaan atau didapat
Ex: Sindrom Asherman, Leiomioma, anomali saluran genital kongenital (unikornu, bikornu, septate uterine)
38
El Hachem, H., Crepaux, V., May-Panloup, P., Descamps, P., Legendre, G., & Bouet, P. E. (2017). Recurrent pregnancy loss: current perspectives. International journal of women's health, 9, 331.
FAKTOR IMUNOLOGIS
RPL lebih sering pd wanita dgn SLE maupun sindrom antifosfolipid dan memiliki antibodi lebih tinggi
Kehamilan normal membutuhkan faktor penghambat antigen janin yg diturunkan dari ayah
39
El Hachem, H., Crepaux, V., May-Panloup, P., Descamps, P., Legendre, G., & Bouet, P. E. (2017). Recurrent pregnancy loss: current perspectives. International journal of women's health, 9, 331.
FAKTOR IMUNOLOGIS
40
FAKTOR ENDOKRIN
Arrendondo dan Noble (2006), terjadi 8-12% pada RPL
Ex: defisiensi progesteron fase luteal , PCOS, diabetes, hipotiroidisme, defisiensi yodium berat
Tx: kontrol glikemik, suplementasi hormon tiroid
41
El Hachem, H., Crepaux, V., May-Panloup, P., Descamps, P., Legendre, G., & Bouet, P. E. (2017). Recurrent pregnancy loss: current perspectives. International journal of women's health, 9, 331.
KONTRASEPSI POST ABORTUS
43
Setelah manajemen medis atau pembedahan untuk terminasi kehamilan, ovulasi dapat dimulai paling cepat 8 hari, tetapi waktu rata-rata adalah 3 minggu
AKDR dapat diinsersikan setelah prosedur atau aborsi medis selesai
Atau, kontrasepsi hormonal dapat dimulai pada saat yang samaStoddard A, Eisenberg DL: Controversies in family planning: timing of ovulation after
abortion and the conundrum of postabortion intrauterine device insertion. Contraception 84(2) : 119, 2011
1. Which of the following sonogram findings is consistent with the American College of Obstetricians and Gynecologists definition of early pregnancy loss?
◦ a. An anembryonic pregnancy
◦ b. A crown-rump length of 7 mm with no cardiac motion
◦ c. A fetus measuring 13 weeks’ gestation with no cardiac motion
◦ d. All of the above
2. What percent of spontaneous abortions occur within the first 12 weeks of gestation?
◦ a. 60%
◦ b. 70%
◦ c. 80%
◦ d. 90%
3. A 22-year-old G1P0 presents for a follow-up visit after receiving care for a spontaneous abortion at 8 weeks’ gestation. She has many questions regarding the possible cause of her miscarriage, and the risk of recurrence. You counsel her that approximately what percentage of pregnancies end in miscarriage?
◦ a. 3–5%
◦ b. 5–10%
◦ c. 10–25%
◦ d. 40%
4. For the patient in Question 18–3, you also counsel her regarding the rate of aneuploidy in first-trimester miscarriages. What is the approximate rate of aneuploidy in pregnancies that end in a clinically apparent first trimester spontaneous abortion?
◦ a. 10%
◦ b. 20%
◦ c. 33%
◦ d. 50%
5. Which of the following chromosomal abnormalities is most common in the setting of first-trimester spontaneous abortion?
◦ a. Trisomy 18
◦ b. Trisomy 21
◦ c. Tetraploidy
◦ d. Monosomy X (Turner syndrome)
6. Consumption of which of the following legal substances in large quantities is most clearly associated with an increased risk of miscarriage?
◦ a. Alcohol
◦ b. Tobacco
◦ c. Caffeine
◦ d. Phthalates
7. A 20-year-old G2P0A2 presents for follow-up after a spontaneous miscarriage at 7 weeks’ gestation. She demands that you “do something” to prevent miscarriages in her future pregnancies. You offer evaluation for recurrent pregnancy loss, but provide reassurance that her likelihood of a successful next pregnancy is approximately what percent?
◦ a. 74%
◦ b. 82%
◦ c. 86%
◦ d. 92%
8. Which of the following is not a widely accepted cause of recurrent pregnancy loss?
◦ a. Uterine structural abnormalities
◦ b. Parental chromosomal abnormalities
◦ c. Antiphospholipid antibody syndrome
◦ d. Progesterone deficiency (luteal phase defect)
9. What percentage of recurrent pregnancy loss is due to parental chromosomal abnormalities?
◦ a. 2–4%
◦ b. 6–8%
◦ c. 10%
◦ d. 15%
10. Which of the following clinical scenarios is not an indication for antiphospholipid antibody testing?
◦ a. History of three embryonic losses
◦ b. History of fetal loss at 16 weeks’ gestation
◦ c. History of unexplained thromboembolism
◦ d. History of severe preeclampsia requiring delivery at 38 weeks’ gestation
11 A 22-year-old G1 undergoes a routine sonogram to survey fetal anatomy at 20 weeks’ gestation. The cervix is noted to appear short on transabdominal imaging and a transvaginal cervical length is performed, measuring 19 mm. According to the American College of Obstetricians and Gynecologists, what is the recommended therapy?
◦ a. Cerclage placement
◦ b. Daily vaginal progesterone
◦ c. 17-Hydroxyprogesterone acetate injections weekly
◦ d. Expectant management with repeat cervical
◦ length in 1 week
12. Among women who become pregnant while using contraception, the relative number of ectopic pregnancies is increased with which of the following contraceptives?
◦ a. Condoms
◦ b. NuvaRing
◦ c. Progestin-releasing intrauterine device
◦ d. Estrogen-containing birth control pills
13. In ectopic pregnancies, the absence of which tubal tissue layer facilitates rapid invasion of proliferating trophoblasts into the muscularis?
◦ a. Serosa
◦ b. Epithelium
◦ c. Submucosa
◦ d. Connective tissue
14. What is the classic triad of clinical symptoms of an ectopic pregnancy?
◦ a. Nausea, pain, and vaginal bleeding
◦ b. Delayed menstruation, pain, and vaginal bleeding
◦ c. Dizziness, delayed menstruation, and vaginal bleeding
◦ d. Shoulder pain, delayed menstruation, and vaginal bleeding
15. A 38-year-old G4P3 presents with a positive pregnancy test, vaginal bleeding, palpitations, and intense neck and shoulder pain, which is worse with inspiration. She is found to be tachycardic and hypotensive. Her ultrasound reveals a likely right ectopic pregnancy. What is the most likely cause of her neck and shoulder pain?
◦ a. A pulled back muscle
◦ b. Referred pain from her right fallopian tube
◦ c. Diaphragmatic irritation due to hemoperitoneum
◦ d. None of the above
16. Which clinical or laboratory finding is least consistent with the diagnosis of a ruptured ectopic pregnancy?
◦ a. Fever of 39.8°C
◦ b. Heart rate of 137 bpm
◦ c. Hematocrit of 21.2%
◦ d. Leukocytosis of 28,000 μL
17. A 30-year-old G2P1 presents at 6 weeks’ gestation by last menstrual period complaining of pelvic pain and nausea. Her β-hCG is 3010 mIU/mL, and no intrauterine pregnancy is seen on ultrasound. Noadnexal masses or free fluid are visualized. What is the best management strategy?
◦ a. No intervention
◦ b. Surgical therapy
◦ c. Methotrexate injection
◦ d. Expectant management with 48-hour follow-up
18. What is the discriminatory β-hCG level above which failure to visualize an intrauterine pregnancy likely indicates that a pregnancy either is not alive or is ectopically located?
◦ a. ≥100 mIU/mL
◦ b. ≥500 mIU/mL
◦ c. ≥1000 mIU/mL
◦ d. ≥1500 mIU/m
19. What is the minimum rise of β-hCG you expect in 48 hours from an early progressing intrauterine pregnancy?
◦ a. 12%
◦ b. 23%
◦ c. 53%
◦ d. 67%
20. What percentage of ectopic pregnancies demonstrate appropriately rising β-hCG levels?
◦ a. 15%
◦ b. 33%
◦ c. 42%
◦ d. 50%
◦ 21. Which of the following statements regarding steroidogenesis is FALSE?
◦ a. Steroid production primarily occurs in the Golgi apparatus.
◦ b. The primary building block of sex steroid hormones is cholesterol.
◦ c. The enzymes involved in steroid production are members of the cytochrome P450 super family.
◦ d. The placenta is the only steroid-producing tissue that cannot synthesize cholesterol rom its precursor, acetate.
◦Steroidogenesis is the multistep process for biosynthesis of steroid hormones from cholesterol.
◦ 22. The last step in estrogen synthesis requires which of the following enzymes?
◦ a. Aromatase
◦ b. 21-hydroxylase
◦ c. 5α-reductase
◦ d. 11β-hydroxylase
◦ 23. All of the following tissues express significant levels of aromatase EXCEPT:
◦ a. Skin
◦ b. Brain
◦ c. Ovary
◦ d. Muscle
24. What is the predominant estrogen during menopause?
◦ a. Estriol
◦ b. Estrone
◦ c. Estradiol
◦ d. None of the above
25. Which of the following androgens is NOT produced by the ovary?
◦ a. Testosterone
◦ b. Androstenedione
◦ c. Dihydrotestosterone (DHT)
◦ d. Dehydroepiandrosterone (DHEA)
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